Glybenzcyclamide

Description

Glybenzcyclamide · CAS 10238-21-8 · C23H28ClN3O5S. UNII SX6K58TVWC. Melting Point: 169; Melting Point: 169 - 170 °C; Solubility: 2.06e-03 g/L.

Identification

CAS Registry Number	10238-21-8
PubChem CID	3488
Molecular formula	C23H28ClN3O5S
IUPAC name	5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
UNII (FDA)	SX6K58TVWC

Computed Descriptors

Molecular Weight	494.0
XLogP3	4.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	493.1438199
Monoisotopic Mass	493.1438199
Topological Polar Surface Area	122
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Melting Point	169
Melting Point	169 - 170 °C
Solubility	2.06e-03 g/L
LogP	3.754
LogP	4.7
LogP	3.09

Physical description & handling notes

• Solid
• 213.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID0037237]
• 206.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0037237]
• 217.6 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0037237]
• 204.7 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 205.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1.1% (1 / 95)

GHS Hazard Classification

GHS notification summary	1.1% (1 / 95)
Reported hazard statements	H302 (89.5%), H413 (93.7%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >750
• Use (kg) in France (2004): 1092
• Consumption (g per capita; approx.) in Germany (2009): 0.00916
• Consumption (g per capita) in the USA (2002): 0.0127
• Consumption (g per capita) in France (2004): 0.0181
• Glyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.

Synonyms

Glibenclamide; glyburide; 10238-21-8; Glynase; Euglucon; Semi-daonil; Libanil; Calabren; Lederglib; Glibenclamida; Glibenclamidum; Glyburide (micronized); HB 419; 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea; 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide; Gliken

Frequently Asked Questions

What are the CAS number and molecular formula of Glybenzcyclamide?

CAS 10238-21-8; molecular formula C23H28ClN3O5S; molecular weight — g/mol.

What other names is Glybenzcyclamide known by?

Glibenclamide, glyburide, 10238-21-8, Glynase, Euglucon, Semi-daonil.

Is Glybenzcyclamide classified as hazardous?

1.1% of GHS notifications report no hazard classification (1 of 95).

What are the key physical properties of Glybenzcyclamide?

Melting Point: 169; Melting Point: 169 - 170 °C; Solubility: 2.06e-03 g/L; LogP: 3.754.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.