Gestodene (CAS 60282-87-3) — formula C21H26O2, molecular weight 310.4; category organic chemicals.
| CAS Number | 60282-87-3 |
|---|---|
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.4 |
| Melting Point | 197.9 |
| LogP | 3.45 |
| Applications | Uses: MEDICATION, ... a progestogen hormonal contraceptive, Use (kg) in Switzerland (2009): >1, Consumption (g per capita) in Switzerland (2009): 0.00013, Calculated removal (%): 18.9, Methods of Manufacturing: Prepn: Belg. pat. 847, 090, H. Hofmeister et al., U.S. pat. 4, 081, 537 (1977, 1978 both to Schering AG)., It can be prepared from the 17-keto steriod [18-methylestrone methyl ether] in a multistep synthesis involving palladium-catalysed conversion of its enol ether to an enone, reduction to the corresponding allylic alcohol, partial reduction of the aromatic ring, regeneration of the enone and ethinylation., Formulations, Preparations: Oral: Tablets: 30 ug ethinylestradiol and 50 ug gestodene, Triadene (Bayer plc)., Gestodene is available commercially as a component of combination tablets with ethinylestradiol., General Manufacturing Information: ...manufactured or formulated in Argentina, Austria, Belgium, Brazil, Finland, France, Germany, Mexico, the Netherlands, New Zealand, Portugal, South Africa, Spain, Switzerland and the United Kingdom., ...used only in combination with ethinyloestradiol as an oral contraceptive, at a dose of 0.075mg gestodene and 20 or 30 ug ethinyloestradiol, and in a triphasic regimen at 0.05, 0.07 and 0.1mg and 30, 40 and 30 ug ethinyloestradiol., Combination preparation with ethinyl estradiol: Femovan (Schering AG). |
| Category | Organic Chemicals |
Documented applications: Uses: MEDICATION, ... a progestogen hormonal contraceptive, Use (kg) in Switzerland (2009): >1, Consumption (g per capita) in Switzerland (2009): 0.00013, Calculated removal (%): 18.9, Methods of Manufacturing: Prepn: Belg. pat. 847, 090, H. Hofmeister et al., U.S. pat. 4, 081, 537 (1977, 1978 both to Schering AG)., It can be prepared from the 17-keto steriod [18-methylestrone methyl ether] in a multistep synthesis involving palladium-catalysed conversion of its enol ether to an enone, reduction to the corresponding allylic alcohol, partial reduction of the aromatic ring, regeneration of the enone and ethinylation., Formulations, Preparations: Oral: Tablets: 30 ug ethinylestradiol and 50 ug gestodene, Triadene (Bayer plc)., Gestodene is available commercially as a component of combination tablets with ethinylestradiol., General Manufacturing Information: ...manufactured or formulated in Argentina, Austria, Belgium, Brazil, Finland, France, Germany, Mexico, the Netherlands, New Zealand, Portugal, South Africa, Spain, Switzerland and the United Kingdom., ...used only in combination with ethinyloestradiol as an oral contraceptive, at a dose of 0.075mg gestodene and 20 or 30 ug ethinyloestradiol, and in a triphasic regimen at 0.05, 0.07 and 0.1mg and 30, 40 and 30 ug ethinyloestradiol., Combination preparation with ethinyl estradiol: Femovan (Schering AG)..
Gestodene is a carbon-based organic compound with CAS registry number 60282-87-3 and molecular formula C21H26O2 (molecular weight 310.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 60282-87-3
Its molecular formula C21H26O2 comprises 21 C, 26 H, 2 O atoms.
Also known as: Gestodene · 孕二烯酮
Category: organic chemicals
The CAS registry number of Gestodene is 60282-87-3.
Molecular formula C21H26O2, molecular weight 310.4.
It is also registered under: Gestodene, 孕二烯酮.
Recorded applications: Uses: MEDICATION, ... a progestogen hormonal contraceptive, Use (kg) in Switzerland (2009): >1, Consumption (g per capita) in Switzerland (2009): 0.00013, Calculated removal (%): 18.9, Methods of Manufacturing: Prepn: Belg. pat. 847, 090, H. Hofmeister et al., U.S. pat. 4, 081, 537 (1977, 1978 both to Schering AG)., It can be prepared from the 17-keto steriod [18-methylestrone methyl ether] in a multistep synthesis involving palladium-catalysed conversion of its enol ether to an enone, reduction to the corresponding allylic alcohol, partial reduction of the aromatic ring, regeneration of the enone and ethinylation., Formulations, Preparations: Oral: Tablets: 30 ug ethinylestradiol and 50 ug gestodene, Triadene (Bayer plc)., Gestodene is available commercially as a component of combination tablets with ethinylestradiol., General Manufacturing Information: ...manufactured or formulated in Argentina, Austria, Belgium, Brazil, Finland, France, Germany, Mexico, the Netherlands, New Zealand, Portugal, South Africa, Spain, Switzerland and the United Kingdom., ...used only in combination with ethinyloestradiol as an oral contraceptive, at a dose of 0.075mg gestodene and 20 or 30 ug ethinyloestradiol, and in a triphasic regimen at 0.05, 0.07 and 0.1mg and 30, 40 and 30 ug ethinyloestradiol., Combination preparation with ethinyl estradiol: Femovan (Schering AG)..
Category: Organic Chemicals.
Independent reference data for Gestodene (CAS 60282-87-3), compiled from public chemistry databases.
| CAS Registry Number | 60282-87-3 |
|---|---|
| PubChem CID | 3033968 |
| Molecular formula | C21H26O2 |
| IUPAC name | (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14-decahydrocyclopenta[a]phenanthren-3-one |
| UNII (FDA) | 1664P6E6MI |
| Molecular Weight | 310.4 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 310.193280068 |
| Monoisotopic Mass | 310.193280068 |
| Topological Polar Surface Area | 37.3 |
| Heavy Atom Count | 23 |
| Melting Point | 197.9 |
|---|---|
| Melting Point | 197.9 °C |
| LogP | 3.45 |
GESTODENE; 60282-87-3; Gestoden; Gestodeno; SH B 331; Gestodenum; DTXSID6046478; SH-B-331; 1664P6E6MI; DTXCID4026478; 13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregna-4,15-dien-20-yn-3-one; 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)-; Pregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-18,19-dinor-, (17alpha)-; 17-alpha-ethinyl-13-ethyl-17 beta-hydroxy-4,15-gonadien-3-one; RefChem:639914; 13-ethyl-17-hydroxy-18,19-dinor-17 alpha-pregna-4,15-dien-20-yn-3-one
| Reported hazard statements | H351 (28.4%), H360 (51.1%), H361 (46.6%), H362 (29.5%), H400 (28.4%), H410 (28.4%) |
|---|
H351 (28.4%): Suspected of causing cancer [Warning Carcinogenicity]
H360 (51.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Gestodene · CAS 60282-87-3 · C21H26O2. UNII 1664P6E6MI. Melting Point: 197.9; Melting Point: 197.9 °C; LogP: 3.45.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 孕二烯酮