Gemcitabine Hcl

Description

Gemcitabine Hcl · CAS 122111-03-9 · C9H12ClF2N3O4. UNII U347PV74IL.

Identification

CAS Registry Number	122111-03-9
PubChem CID	60749
Molecular formula	C9H12ClF2N3O4
IUPAC name	4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
UNII (FDA)	U347PV74IL

Computed Descriptors

Molecular Weight	299.66
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	299.0484399
Monoisotopic Mass	299.0484399
Topological Polar Surface Area	108
Heavy Atom Count	19
Formal Charge	0
Complexity	426

GHS Hazard Classification

Reported hazard statements	H302 (11.3%), H312 (25.8%), H315 (12.9%), H319 (30.6%), H340 (25.8%), H360 (85.5%), H361 (11.3%)

Documented Uses

• Gemcitabine hydrochloride is approved to be used alone or with other drugs to treat:
• • Breast cancer that cannot be treated with or that did not respond to chemotherapy that included an anthracycline drug. It is used with paclitaxel as the first therapy for cancer that has spread to other parts of the body.
• • Non-small cell lung cancer. It is used with cisplatin in patients whose cancer is stage IIIA, stage IIIB, or stage IV.
• • Ovarian cancer that is advanced and has relapsed at least 6 months after treatment with platinum chemotherapy. It is used with carboplatin.
• • Pancreatic cancer. It is used alone in patients whose cancer is stage II or stage III and cannot be removed by surgery or stage IV. It is used in patients whose cancer has been treated with fluorouracil.
• Gemcitabine hydrochloride is also being studied in the treatment of other types of cancer.

Synonyms

GEMCITABINE HYDROCHLORIDE; 122111-03-9; Gemcitabine HCl; LY188011 hydrochloride; 2'-Deoxy-2',2'-difluorocytidine monohydrochloride; 2'-deoxy-2',2'-difluorocytidine hydrochloride; INFUGEM; Gemcitabine (as hydrochloride); Cytidine, 2'-deoxy-2',2'-difluoro-, monohydrochloride; DTXSID3047849; Gemcitabine HCI; U347PV74IL; LY-188011 HYDROCHLORIDE; 2',2'-Difluorodeoxycytidine monohydrochloride; DTXCID3027827; NSC613327

Frequently Asked Questions

What are the CAS number and molecular formula of Gemcitabine Hcl?

CAS 122111-03-9; molecular formula C9H12ClF2N3O4; molecular weight — g/mol.

What other names is Gemcitabine Hcl known by?

GEMCITABINE HYDROCHLORIDE, 122111-03-9, Gemcitabine HCl, LY188011 hydrochloride, 2'-Deoxy-2',2'-difluorocytidine monohydrochloride, 2'-deoxy-2',2'-difluorocytidine hydrochloride.

Is Gemcitabine Hcl classified as hazardous?

Hazard statements reported: H302, H312, H315, H319, H340.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.