Ganciclovir (CAS 82410-32-0) — formula C9H13N5O4, molecular weight 255.23; category organic chemicals.
| CAS Number | 82410-32-0 |
|---|---|
| Molecular Formula | C9H13N5O4 |
| Molecular Weight | 255.23 |
| Melting Point | 250 |
| LogP | -1.66 |
| Applications | Uses: MEDICATION, Antiviral Agents, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 75.1, Methods of Manufacturing: 2-O-(Acetoxymethyl)-1, 3-di-O-benzylglycerol is condensed with N2, 9-diacetylguanine in the presence of a catalytic amount of p-toluenesulfonic acid in sulfolane. The desired isomer is crystallized from toluene, debenzylated over 20% palladiumhydroxide, and deacetylated with concentrated NH4OH, methanol., Preparation: J. P. Verheyden, J. C. Martin, United States of America patent 4355032 (1982 to Syntex), Formulations, Preparations: Vials, containing granciclovir sodium equivalent to 500 mg ganciclovir., Parenteral: Sterile, for iv infusion, 500 mg (of ganciclovir), Cytovene, Syntex., Ganciclovir sodium, Cymevan, Cymevene, Denosine., Zirgan (ganciclovir ophthalmic gel) ganciclovir 1.5 mg (0.15%)., General Manufacturing Information: Nucleoside analog structurally related to acyclovir |
| Category | Organic Chemicals |
Documented applications: Uses: MEDICATION, Antiviral Agents, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 75.1, Methods of Manufacturing: 2-O-(Acetoxymethyl)-1, 3-di-O-benzylglycerol is condensed with N2, 9-diacetylguanine in the presence of a catalytic amount of p-toluenesulfonic acid in sulfolane. The desired isomer is crystallized from toluene, debenzylated over 20% palladiumhydroxide, and deacetylated with concentrated NH4OH, methanol., Preparation: J. P. Verheyden, J. C. Martin, United States of America patent 4355032 (1982 to Syntex), Formulations, Preparations: Vials, containing granciclovir sodium equivalent to 500 mg ganciclovir., Parenteral: Sterile, for iv infusion, 500 mg (of ganciclovir), Cytovene, Syntex., Ganciclovir sodium, Cymevan, Cymevene, Denosine., Zirgan (ganciclovir ophthalmic gel) ganciclovir 1.5 mg (0.15%)., General Manufacturing Information: Nucleoside analog structurally related to acyclovir.
Ganciclovir is a carbon-based organic compound with CAS registry number 82410-32-0 and molecular formula C9H13N5O4 (molecular weight 255.23), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 82410-32-0
Its molecular formula C9H13N5O4 comprises 9 C, 13 H, 5 N, 4 O atoms.
Also known as: Ganciclovir · 更昔洛韦
Category: organic chemicals
The CAS registry number of Ganciclovir is 82410-32-0.
Molecular formula C9H13N5O4, molecular weight 255.23.
It is also registered under: Ganciclovir, 更昔洛韦.
Recorded applications: Uses: MEDICATION, Antiviral Agents, Use (kg, approx.) in Germany (2009): >25, Consumption (g per capita, approx.) in Germany (2009): 0.000305, Calculated removal (%): 75.1, Methods of Manufacturing: 2-O-(Acetoxymethyl)-1, 3-di-O-benzylglycerol is condensed with N2, 9-diacetylguanine in the presence of a catalytic amount of p-toluenesulfonic acid in sulfolane. The desired isomer is crystallized from toluene, debenzylated over 20% palladiumhydroxide, and deacetylated with concentrated NH4OH, methanol., Preparation: J. P. Verheyden, J. C. Martin, United States of America patent 4355032 (1982 to Syntex), Formulations, Preparations: Vials, containing granciclovir sodium equivalent to 500 mg ganciclovir., Parenteral: Sterile, for iv infusion, 500 mg (of ganciclovir), Cytovene, Syntex., Ganciclovir sodium, Cymevan, Cymevene, Denosine., Zirgan (ganciclovir ophthalmic gel) ganciclovir 1.5 mg (0.15%)., General Manufacturing Information: Nucleoside analog structurally related to acyclovir.
Category: Organic Chemicals.
Independent reference data for Ganciclovir (CAS 82410-32-0), compiled from public chemistry databases.
| PubChem CID | 135398740 |
|---|---|
| 分子式 | C9H13N5O4 |
| IUPAC 名称 | 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one |
| UNII（FDA） | P9G3CKZ4P5 |
| Molecular Weight | 255.23 |
|---|---|
| XLogP3 | -2.5 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 255.09675391 |
| Monoisotopic Mass | 255.09675391 |
| Topological Polar Surface Area | 135 |
| Heavy Atom Count | 18 |
| Melting Point | 250 |
|---|---|
| Melting Point | 250 °C (decomposes) |
| Melting Point | 250 °C |
| Solubility | 4300 |
| Solubility | In water (25 °C): 4.3 mg/mL at pH 7 |
| Solubility | 1.16e+01 g/L |
| LogP | -1.66 |
| LogP | log Kow = -1.66 |
| LogP | -1.7 |
| Dissociation Constants | pKa1 2.2; pKa2 9.4 |
ganciclovir; 82410-32-0; Gancyclovir; Vitrasert; Zirgan; BW-759U; Ganciclovirum; RS-21592; BW 759U; Cymevene; Virgan; Cymevan; 2'-Nor-2'-deoxyguanosine; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; DTXSID8041032
| 已通报的危害声明 | H360 (93.5%) |
|---|
更昔洛韦 · C9H13N5O4. UNII P9G3CKZ4P5. Melting Point: 250; Melting Point: 250 °C (decomposes); Melting Point: 250 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 更昔洛韦