Flurandrenolide

Description

Flurandrenolide · CAS 1524-88-5 · C24H33FO6. UNII 8EUL29XUQT. Melting Point: 251; Melting Point: 247-255 °C; Melting Point: 251 °C.

Identification

CAS Registry Number	1524-88-5
PubChem CID	15209
Molecular formula	C24H33FO6
IUPAC name	(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
UNII (FDA)	8EUL29XUQT

Computed Descriptors

Molecular Weight	436.5
XLogP3	1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	436.22611693
Monoisotopic Mass	436.22611693
Topological Polar Surface Area	93.1
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	251
Melting Point	247-255 °C
Melting Point	251 °C
Solubility	5.78e-02 g/L
LogP	0.6

Physical description & handling notes

• Solid
• Crystals from acetone + hexane
• WHITE TO OFF-WHITE, FLUFFY CRYSTALLINE POWDER
• ODORLESS
• Insoluble
• FREELY SOL IN CHLOROFORM; SOL IN METHANOL; SPARINGLY SOL IN ALC; PRACTICALLY INSOL IN WATER & ETHER

GHS Hazard Classification

Reported hazard statements	H319 (97.6%)

Documented Uses

• For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dry, scaling localized lesions.
• THERAP CAT: Glucocorticoid; antipsoriatic
• Prepn: Ringold et al, German patent 1,131,213 corresponds to US patent 3,126,375 (1962, 1964 both to Syntex).
• FLURANDRENOLONE (6ALPHA-FLUORO-16ALPHA-HYDROXY-CORTISOL) IS CONDENSED WITH ACETONE BY TREATING ITS SOLN IN ACETONE WITH 70% PERCHLORIC ACID.
• NEOMYCIN IS OFTEN INCL IN TOPICAL PREPN OF FLURANDRENOLIDE TO SUPPRESS INFECTIONS SECONDARY TO INFLAMMATORY PROCESS OR TO USE OF GLUCOCORTICOID.
• Breast Feeding; Lactation; Corticosteroids, Topical; Glucocorticoids; Anti-Inflammatory Agents

Synonyms

flurandrenolide; Fludroxycortide; 1524-88-5; Flurandrenolone; Cordran; Haelan; Fluorandrenolone; Drenison; Drocort; Sermaka; Flurandrenolone acetonide; Fluorandrenolone acetonide; Haldrone-F; Alondra-F; Fludroxicortida; Fludroxycortidum

Frequently Asked Questions

What are the CAS number and molecular formula of Flurandrenolide?

CAS 1524-88-5; molecular formula C24H33FO6; molecular weight — g/mol.

What other names is Flurandrenolide known by?

flurandrenolide, Fludroxycortide, 1524-88-5, Flurandrenolone, Cordran, Haelan.

Is Flurandrenolide classified as hazardous?

Hazard statements reported: H319.

What are the key physical properties of Flurandrenolide?

Melting Point: 251; Melting Point: 247-255 °C; Melting Point: 251 °C; Solubility: 5.78e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.