Flumequine (CAS 42835-25-6) — formula C14H12FNO3, molecular weight 261.25; category organic chemicals.
| CAS Number | 42835-25-6 |
|---|---|
| Molecular Formula | C14H12FNO3 |
| Molecular Weight | 261.25 |
| Melting Point | 253-255 °C |
| LogP | log Kow = 1.6 |
| Applications | Uses: Anti-Infective Agents, Urinary, Topoisomerase II Inhibitors, MEDICATION, MEDICATION (VET), Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: Preparation: J.F. Gerster, German patent 2264163, idem USA patent 3896131 (1973, 1975 both to Riker)., Condensation of 5-fluoro-2-methyltetrahydroquinoline with diethyl ethoxymethylenemalonate followed by thermal cyclization gives ethyl 6, 7-dihydro-9-fluoro-5-methyl-1-oxo-1H, 5H-benzo(i, j)quinolizine-2-carboxylate, which is saponified with sodium hydroxide to give flumequine., General Manufacturing Information: Authorized or allowed for use in aquaculture (2 day withdrawal time in France). ... Registered or approved for use in aquatic or fishery situations in Japan (20 mg, kg per day) |
| Category | Organic Chemicals |
Documented applications: Uses: Anti-Infective Agents, Urinary, Topoisomerase II Inhibitors, MEDICATION, MEDICATION (VET), Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: Preparation: J.F. Gerster, German patent 2264163, idem USA patent 3896131 (1973, 1975 both to Riker)., Condensation of 5-fluoro-2-methyltetrahydroquinoline with diethyl ethoxymethylenemalonate followed by thermal cyclization gives ethyl 6, 7-dihydro-9-fluoro-5-methyl-1-oxo-1H, 5H-benzo(i, j)quinolizine-2-carboxylate, which is saponified with sodium hydroxide to give flumequine., General Manufacturing Information: Authorized or allowed for use in aquaculture (2 day withdrawal time in France). ... Registered or approved for use in aquatic or fishery situations in Japan (20 mg, kg per day).
Flumequine is a carbon-based organic compound with CAS registry number 42835-25-6 and molecular formula C14H12FNO3 (molecular weight 261.25), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 42835-25-6
Its molecular formula C14H12FNO3 comprises 14 C, 12 H, 1 F, 1 N, 3 O atoms.
Also known as: Flumequine · 氟甲喹
Category: organic chemicals
The CAS registry number of Flumequine is 42835-25-6.
Molecular formula C14H12FNO3, molecular weight 261.25.
It is also registered under: Flumequine, 氟甲喹.
Recorded applications: Uses: Anti-Infective Agents, Urinary, Topoisomerase II Inhibitors, MEDICATION, MEDICATION (VET), Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: Preparation: J.F. Gerster, German patent 2264163, idem USA patent 3896131 (1973, 1975 both to Riker)., Condensation of 5-fluoro-2-methyltetrahydroquinoline with diethyl ethoxymethylenemalonate followed by thermal cyclization gives ethyl 6, 7-dihydro-9-fluoro-5-methyl-1-oxo-1H, 5H-benzo(i, j)quinolizine-2-carboxylate, which is saponified with sodium hydroxide to give flumequine., General Manufacturing Information: Authorized or allowed for use in aquaculture (2 day withdrawal time in France). ... Registered or approved for use in aquatic or fishery situations in Japan (20 mg, kg per day).
Category: Organic Chemicals.
Independent reference data for Flumequine (CAS 42835-25-6), compiled from public chemistry databases.
| CAS 号 | 42835-25-6 |
|---|---|
| PubChem CID | 3374 |
| 分子式 | C14H12FNO3 |
| IUPAC 名称 | 7-fluoro-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid |
| UNII（FDA） | UVG8VSP2SJ |
| Molecular Weight | 261.25 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 1 |
| Exact Mass | 261.08012141 |
| Monoisotopic Mass | 261.08012141 |
| Topological Polar Surface Area | 57.6 |
| Heavy Atom Count | 19 |
| Melting Point | 253-255 °C |
|---|---|
| Melting Point | 253 - 255 °C |
| LogP | log Kow = 1.6 |
| LogP | 1.60 |
| LogP | 1.72 |
| Dissociation Constants | 6.38 |
| Dissociation Constants | 6.27 |
| Dissociation Constants | pKa = 6.5 |
| Collision Cross Section | 150.58 Ų [M+H]+ |
| Collision Cross Section | 164.97 Ų [M+Na]+ |
flumequine; 42835-25-6; Apurone; Flumigal; Imequyl; Flumequino; Flumequinum; Flumiquil; Flumisol; Flumix; DTXSID5045623; R-802; Flumequina; UVG8VSP2SJ; NSC-757806; 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1h,5h-benzo[ij]quinolizine-2-carboxylic acid
| 法规与食品接触 | ANTIMICROBIAL_AGENT: Veterinary Drug 0-30 µg/kg bw TRS 939-JECFA 66/45 FAS 53-JECFA 62/93 (2004) |
|---|---|
| GHS 通报统计 | 22.2% (6 / 27) |
| GHS 通报统计 | 22.2% (6 / 27) |
|---|---|
| 已通报的危害声明 | H315 (63%), H317 (70.4%), H334 (70.4%) |
氟甲喹 · CAS 42835-25-6 · C14H12FNO3. UNII UVG8VSP2SJ. Melting Point: 253-255 °C; Melting Point: 253 - 255 °C; LogP: log Kow = 1.6.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 氟甲喹