ethyl N-acetyl-N-butyl-β-alaninate (CAS 52304-36-6) — formula C11H21NO3, molecular weight 215.29; category organic chemicals.
| CAS Number | 52304-36-6 |
|---|---|
| Molecular Formula | C11H21NO3 |
| Molecular Weight | 215.29 |
| Melting Point | Less than -20 °C |
| Boiling Point | BP: 108-110 °C at 0.2 mm Hg; 126-127 °C at 0.5 mm Hg |
| LogP | log Kow = 1.7 at 23 °C |
| Applications | Uses: For ethyl 3-(N-butylacetamido)propionate (USEPA, OPP Pesticide Code: 113509) ACTIVE products with label matches., SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., IR3535 is an insect repellent for application to human skin and clothing in public health applications, to repel biting arthropods such as mosquitoes, flies and ticks., ... Current prevention tools, for zika and other arboviruses, are mainly represented by the employ of mosquito repellents, light-colored clothes covering as much of the body as possible, and sleeping under mosquito nets. Concerning chemically derived repellents, the number of these products has been considerably reduced by the European Community. Therefore, there are rather few compounds left, including DEET (N, Ndiethyl-m-toluamide), IR3535 (3-N-acetyl-N-butylamino-proprionic ethyl ester), icaridin (i.e. Saltidin, 1-piperidine-carboxylic acid 2-2 hydroxyethyl-1-methylester), and also an Eucalyptus citriodora derivative (para-menthane-3, 8-diol), Use Classification: Cosmetics -> Surfactant, Skin conditioning, Formulations, Preparations: Avon SSS Skin-So-Soft Gentle Breeze Bug Guard Plus IR3535 Insect Repellent (New Avon LLC): Active ingredient: .beta.-Alanine, N-acetyl-N-butyl-, ethyl ester 7.5%., Avon SSS Skin-So-Soft Bug Guard Plus IR3535 Insect Repellent SPF 30 Moisturizing Sunblock Lotion Cool 'N Fabulous (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent SPF 15 Sunscreen Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, For more Formulations, Preparations (Complete) data for Ethyl butylacetylaminopropionate (23 total), please visit the HSDB record page., General Manufacturing Information: Travelers are confronted with a variety of vector-borne threats. Is one type of repellent effective against all biting vectors? The aim of this review is to examine the literature, up to December 31st, 2012, regarding repellent efficacy. We searched PubMed for relevant papers. Repellents of interest were DEET, Icaridin as well as other piperidine-derived products (SS220), Insect Repellent (IR) 3535 (ethyl-butylacetyl-amino-propionat, EBAAP) and plant-derived products, including Citriodora (para-menthane-3, 8-diol). As vectors, we considered the mosquito species Anopheles, Aedes and Culex as well as the tick species Ixodes. We selected only studies evaluating the protective efficacy of repellents on human skin. We reviewed a total of 102 publications. Repellents were evaluated regarding complete protection time or as percentage efficacy [%] in a time interval. We found no standardized study for tick bite prevention. Regarding Aedes, DEET at concentration of 20% or more, showed the best efficacy providing up to 10 hr protection. Citriodora repellency against this mosquito genus was lower compared to the other products. Also between subspecies a difference could be observed: Ae. aegypti proved more difficult to repel than Ae. albopictus. Fewer studies have been conducted on mosquito species Anopheles and Culex. The repellency profile against Anopheles species was similar for the four principal repellents of interest, providing on average 4-10 hr of protection. Culex mosquitoes are easier to repel and all four repellents provided good protection. Few studies have been conducted on the tick species Ixodes. According to our results, the longest protection against Ixodes scapularis was provided by repellents containing IR3535, while DEET and commercial products containing Icaridin or PMD showed a better response than IR3535 against Ixodes ricinus. Many plant-based repellents provide only short duration protection. Adding vanillin 5% to plant-based repellents and to DEET repellents increased the protection by about 2 hr., The insect repellents 3535 (ethyl butylacetylaminopropionate or IR3535) and deet (N, N-diethyl-3-methylbenzamide) were prepared as 20% solutions in absolute ethanol and evaluated for repellency against many mosquito species in Thailand under laboratory and field conditions using human subjects. In the laboratory, 0.1 mL was applied per 30-sq cm of exposed area on a volunteer's forearm (0.66-0.67 mg active ingredient [AI], sq cm), whereas in the field, volunteers' legs (from knee to ankle, with a surface area of about 712-782 sq cm) were treated with 3 mL per exposed area (0.76-0.84 mg AI, sq cm). In the laboratory, both IR3535 and deet showed equal repellency (P > 0.05) for 9.8 and 9.7 hr against Aedes aegypti, for 13.7 and 12.7 hr against Culex quinquefasciatus, and for 14.8 and 14.5 hr against C. tritaeniorhynchus, respectively. Anopheles dirus was significantly less sensitive to IR3535 than to deet (P < 0.05), with a mean protection time of 3.8 and 5.8 hr, respectively. Under field conditions, both IR3535 and deet provided a high degree of protection against various mosquito vectors ranging from 94 to 100% during the test periods. Both repellents provided a high level of protection for at least 8 hr against Ae. albopictus and for at least 5 hr against C. gelidus, C. tritaeniorhynchus, C. quinquefasciatus, Mansonia dives, M. uniformis, M. annulata, M. annulifera, Anopheles minimus, and An. maculatus. This study clearly documents the potential of IR3535 for use as a topical treatment against a wide range of mosquito species belonging to several genera. |
| Category | Organic Chemicals |
Documented applications: Uses: For ethyl 3-(N-butylacetamido)propionate (USEPA, OPP Pesticide Code: 113509) ACTIVE products with label matches., SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., IR3535 is an insect repellent for application to human skin and clothing in public health applications, to repel biting arthropods such as mosquitoes, flies and ticks., ... Current prevention tools, for zika and other arboviruses, are mainly represented by the employ of mosquito repellents, light-colored clothes covering as much of the body as possible, and sleeping under mosquito nets. Concerning chemically derived repellents, the number of these products has been considerably reduced by the European Community. Therefore, there are rather few compounds left, including DEET (N, Ndiethyl-m-toluamide), IR3535 (3-N-acetyl-N-butylamino-proprionic ethyl ester), icaridin (i.e. Saltidin, 1-piperidine-carboxylic acid 2-2 hydroxyethyl-1-methylester), and also an Eucalyptus citriodora derivative (para-menthane-3, 8-diol), Use Classification: Cosmetics -> Surfactant, Skin conditioning, Formulations, Preparations: Avon SSS Skin-So-Soft Gentle Breeze Bug Guard Plus IR3535 Insect Repellent (New Avon LLC): Active ingredient: .beta.-Alanine, N-acetyl-N-butyl-, ethyl ester 7.5%., Avon SSS Skin-So-Soft Bug Guard Plus IR3535 Insect Repellent SPF 30 Moisturizing Sunblock Lotion Cool 'N Fabulous (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent SPF 15 Sunscreen Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, For more Formulations, Preparations (Complete) data for Ethyl butylacetylaminopropionate (23 total), please visit the HSDB record page., General Manufacturing Information: Travelers are confronted with a variety of vector-borne threats. Is one type of repellent effective against all biting vectors? The aim of this review is to examine the literature, up to December 31st, 2012, regarding repellent efficacy. We searched PubMed for relevant papers. Repellents of interest were DEET, Icaridin as well as other piperidine-derived products (SS220), Insect Repellent (IR) 3535 (ethyl-butylacetyl-amino-propionat, EBAAP) and plant-derived products, including Citriodora (para-menthane-3, 8-diol). As vectors, we considered the mosquito species Anopheles, Aedes and Culex as well as the tick species Ixodes. We selected only studies evaluating the protective efficacy of repellents on human skin. We reviewed a total of 102 publications. Repellents were evaluated regarding complete protection time or as percentage efficacy [%] in a time interval. We found no standardized study for tick bite prevention. Regarding Aedes, DEET at concentration of 20% or more, showed the best efficacy providing up to 10 hr protection. Citriodora repellency against this mosquito genus was lower compared to the other products. Also between subspecies a difference could be observed: Ae. aegypti proved more difficult to repel than Ae. albopictus. Fewer studies have been conducted on mosquito species Anopheles and Culex. The repellency profile against Anopheles species was similar for the four principal repellents of interest, providing on average 4-10 hr of protection. Culex mosquitoes are easier to repel and all four repellents provided good protection. Few studies have been conducted on the tick species Ixodes. According to our results, the longest protection against Ixodes scapularis was provided by repellents containing IR3535, while DEET and commercial products containing Icaridin or PMD showed a better response than IR3535 against Ixodes ricinus. Many plant-based repellents provide only short duration protection. Adding vanillin 5% to plant-based repellents and to DEET repellents increased the protection by about 2 hr., The insect repellents 3535 (ethyl butylacetylaminopropionate or IR3535) and deet (N, N-diethyl-3-methylbenzamide) were prepared as 20% solutions in absolute ethanol and evaluated for repellency against many mosquito species in Thailand under laboratory and field conditions using human subjects. In the laboratory, 0.1 mL was applied per 30-sq cm of exposed area on a volunteer's forearm (0.66-0.67 mg active ingredient [AI], sq cm), whereas in the field, volunteers' legs (from knee to ankle, with a surface area of about 712-782 sq cm) were treated with 3 mL per exposed area (0.76-0.84 mg AI, sq cm). In the laboratory, both IR3535 and deet showed equal repellency (P > 0.05) for 9.8 and 9.7 hr against Aedes aegypti, for 13.7 and 12.7 hr against Culex quinquefasciatus, and for 14.8 and 14.5 hr against C. tritaeniorhynchus, respectively. Anopheles dirus was significantly less sensitive to IR3535 than to deet (P < 0.05), with a mean protection time of 3.8 and 5.8 hr, respectively. Under field conditions, both IR3535 and deet provided a high degree of protection against various mosquito vectors ranging from 94 to 100% during the test periods. Both repellents provided a high level of protection for at least 8 hr against Ae. albopictus and for at least 5 hr against C. gelidus, C. tritaeniorhynchus, C. quinquefasciatus, Mansonia dives, M. uniformis, M. annulata, M. annulifera, Anopheles minimus, and An. maculatus. This study clearly documents the potential of IR3535 for use as a topical treatment against a wide range of mosquito species belonging to several genera..
ethyl N-acetyl-N-butyl-β-alaninate is a carbon-based organic compound with CAS registry number 52304-36-6 and molecular formula C11H21NO3 (molecular weight 215.29), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 52304-36-6
Its molecular formula C11H21NO3 comprises 11 C, 21 H, 1 N, 3 O atoms.
Also known as: ethyl N-acetyl-N-butyl-β-alaninate · N-乙酰基-N-丁基-β-丙氨酸乙酯
Category: organic chemicals
The CAS registry number of ethyl N-acetyl-N-butyl-β-alaninate is 52304-36-6.
Molecular formula C11H21NO3, molecular weight 215.29.
It is also registered under: ethyl N-acetyl-N-butyl-β-alaninate, N-乙酰基-N-丁基-β-丙氨酸乙酯.
Recorded applications: Uses: For ethyl 3-(N-butylacetamido)propionate (USEPA, OPP Pesticide Code: 113509) ACTIVE products with label matches., SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., IR3535 is an insect repellent for application to human skin and clothing in public health applications, to repel biting arthropods such as mosquitoes, flies and ticks., ... Current prevention tools, for zika and other arboviruses, are mainly represented by the employ of mosquito repellents, light-colored clothes covering as much of the body as possible, and sleeping under mosquito nets. Concerning chemically derived repellents, the number of these products has been considerably reduced by the European Community. Therefore, there are rather few compounds left, including DEET (N, Ndiethyl-m-toluamide), IR3535 (3-N-acetyl-N-butylamino-proprionic ethyl ester), icaridin (i.e. Saltidin, 1-piperidine-carboxylic acid 2-2 hydroxyethyl-1-methylester), and also an Eucalyptus citriodora derivative (para-menthane-3, 8-diol), Use Classification: Cosmetics -> Surfactant, Skin conditioning, Formulations, Preparations: Avon SSS Skin-So-Soft Gentle Breeze Bug Guard Plus IR3535 Insect Repellent (New Avon LLC): Active ingredient: .beta.-Alanine, N-acetyl-N-butyl-, ethyl ester 7.5%., Avon SSS Skin-So-Soft Bug Guard Plus IR3535 Insect Repellent SPF 30 Moisturizing Sunblock Lotion Cool 'N Fabulous (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, Avon Skin-So-Soft SSS Bug Guard Plus IR3535 Insect Repellent SPF 15 Sunscreen Spray Gentle Breeze (New Avon LLC): Active ingredient: .beta.-Alanine, For more Formulations, Preparations (Complete) data for Ethyl butylacetylaminopropionate (23 total), please visit the HSDB record page., General Manufacturing Information: Travelers are confronted with a variety of vector-borne threats. Is one type of repellent effective against all biting vectors? The aim of this review is to examine the literature, up to December 31st, 2012, regarding repellent efficacy. We searched PubMed for relevant papers. Repellents of interest were DEET, Icaridin as well as other piperidine-derived products (SS220), Insect Repellent (IR) 3535 (ethyl-butylacetyl-amino-propionat, EBAAP) and plant-derived products, including Citriodora (para-menthane-3, 8-diol). As vectors, we considered the mosquito species Anopheles, Aedes and Culex as well as the tick species Ixodes. We selected only studies evaluating the protective efficacy of repellents on human skin. We reviewed a total of 102 publications. Repellents were evaluated regarding complete protection time or as percentage efficacy [%] in a time interval. We found no standardized study for tick bite prevention. Regarding Aedes, DEET at concentration of 20% or more, showed the best efficacy providing up to 10 hr protection. Citriodora repellency against this mosquito genus was lower compared to the other products. Also between subspecies a difference could be observed: Ae. aegypti proved more difficult to repel than Ae. albopictus. Fewer studies have been conducted on mosquito species Anopheles and Culex. The repellency profile against Anopheles species was similar for the four principal repellents of interest, providing on average 4-10 hr of protection. Culex mosquitoes are easier to repel and all four repellents provided good protection. Few studies have been conducted on the tick species Ixodes. According to our results, the longest protection against Ixodes scapularis was provided by repellents containing IR3535, while DEET and commercial products containing Icaridin or PMD showed a better response than IR3535 against Ixodes ricinus. Many plant-based repellents provide only short duration protection. Adding vanillin 5% to plant-based repellents and to DEET repellents increased the protection by about 2 hr., The insect repellents 3535 (ethyl butylacetylaminopropionate or IR3535) and deet (N, N-diethyl-3-methylbenzamide) were prepared as 20% solutions in absolute ethanol and evaluated for repellency against many mosquito species in Thailand under laboratory and field conditions using human subjects. In the laboratory, 0.1 mL was applied per 30-sq cm of exposed area on a volunteer's forearm (0.66-0.67 mg active ingredient [AI], sq cm), whereas in the field, volunteers' legs (from knee to ankle, with a surface area of about 712-782 sq cm) were treated with 3 mL per exposed area (0.76-0.84 mg AI, sq cm). In the laboratory, both IR3535 and deet showed equal repellency (P > 0.05) for 9.8 and 9.7 hr against Aedes aegypti, for 13.7 and 12.7 hr against Culex quinquefasciatus, and for 14.8 and 14.5 hr against C. tritaeniorhynchus, respectively. Anopheles dirus was significantly less sensitive to IR3535 than to deet (P < 0.05), with a mean protection time of 3.8 and 5.8 hr, respectively. Under field conditions, both IR3535 and deet provided a high degree of protection against various mosquito vectors ranging from 94 to 100% during the test periods. Both repellents provided a high level of protection for at least 8 hr against Ae. albopictus and for at least 5 hr against C. gelidus, C. tritaeniorhynchus, C. quinquefasciatus, Mansonia dives, M. uniformis, M. annulata, M. annulifera, Anopheles minimus, and An. maculatus. This study clearly documents the potential of IR3535 for use as a topical treatment against a wide range of mosquito species belonging to several genera..
Category: Organic Chemicals.
Independent reference data for ethyl N-acetyl-N-butyl-β-alaninate (CAS 52304-36-6), compiled from public chemistry databases.
| CAS Registry Number | 52304-36-6 |
|---|---|
| PubChem CID | 104150 |
| Molecular formula | C11H21NO3 |
| IUPAC name | ethyl 3-[acetyl(butyl)amino]propanoate |
| UNII (FDA) | 65GQA237EH |
| Molecular Weight | 215.29 |
|---|---|
| XLogP3 | 1.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 8 |
| Exact Mass | 215.15214353 |
| Monoisotopic Mass | 215.15214353 |
| Topological Polar Surface Area | 46.6 |
| Heavy Atom Count | 15 |
| Boiling Point | BP: 108-110 °C at 0.2 mm Hg; 126-127 °C at 0.5 mm Hg |
|---|---|
| Melting Point | Less than -20 °C |
| Solubility | In water, 7.0X10+4 mg/L at 20 °C |
| Vapor Pressure | 0.15 Pa /1.1X10-3 mm Hg/ at 20 °C |
| LogP | log Kow = 1.7 at 23 °C |
52304-36-6; Ethyl butylacetylaminopropionate; ethyl 3-(N-butylacetamido)propanoate; Quwenzhi; Ethyl 3-(N-butylacetamido)propionate; Ethyl N-acetyl-N-butyl-beta-alaninate; BAAPE; ethyl 3-[acetyl(butyl)amino]propanoate; DTXSID9035753; EUS 26-15; MFCD00214076; 65GQA237EH; AI 3-70763; beta-alanine, N-acetyl-N-butyl-, ethyl ester; 3-[N-n-Butyl-N-acetyl]aminopropionic acid-ethyl ester; Ethyl butylacetylaminopropionate (JAN)
| Regulatory & Food Contact | CIR / INCI: Surfactant; Skin conditioning |
|---|---|
| GHS notification summary | 3.6% (6 / 168) |
| GHS notification summary | 3.6% (6 / 168) |
|---|---|
| Reported hazard statements | H319 (96.4%), H402 |
This chemical does not meet GHS hazard criteria for 3.6% (6 of 168) of reports.
H319 (96.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
ethyl N-acetyl-N-butyl-β-alaninate · CAS 52304-36-6 · C11H21NO3. UNII 65GQA237EH. Boiling Point: BP: 108-110 °C at 0.2 mm Hg; 126-127 °C at 0.5 mm Hg; Melting Point: Less than -20 °C; Solubility: In water, 7.0X10+4 mg/L at 20 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: N-乙酰基-N-丁基-β-丙氨酸乙酯