ethosuximide (CAS 77-67-8) — formula C7H11NO2, molecular weight 141.17.
| CAS Number | 77-67-8 |
|---|---|
| Molecular Formula | C7H11NO2 |
| Molecular Weight | 141.17 |
| Melting Point | 64.5 |
| LogP | 0.38 |
| Applications | Uses: Antiepileptic, THERAP CAT: Anticonvulsant, MEDICATION, For the treatment of petit mal epilepsy., Use Classification: Pharmaceuticals, Methods of Manufacturing: The condensation of butanone with cyano ethyl acetate and subsequent reaction with NaCN and H2SO4 gives 2-ethyl-2-methyl-succinic acid, which is ring-closed via the diammonium salt to yield ethosuximide., Methyl ethyl ketone + ethyl cyanoacetate + hydrogen cyanide + ammonia (Cope reaction, addition, nitrile hydrolysis, decarboxylation, ester hydrolysis, amide formation), Formulations, Preparations: ASAMID, ATYSMAL, CAPITUS, EMESIDE, For more Formulations, Preparations (Complete) data for ETHOSUXIMIDE (31 total), please visit the HSDB record page., U.S. Production: (1972) LESS THAN 10+7 GRAMS (CONSUMPTION EST), U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) No Data, General Manufacturing Information: US PATENT 2, 993, 835. |
Documented applications: Uses: Antiepileptic, THERAP CAT: Anticonvulsant, MEDICATION, For the treatment of petit mal epilepsy., Use Classification: Pharmaceuticals, Methods of Manufacturing: The condensation of butanone with cyano ethyl acetate and subsequent reaction with NaCN and H2SO4 gives 2-ethyl-2-methyl-succinic acid, which is ring-closed via the diammonium salt to yield ethosuximide., Methyl ethyl ketone + ethyl cyanoacetate + hydrogen cyanide + ammonia (Cope reaction, addition, nitrile hydrolysis, decarboxylation, ester hydrolysis, amide formation), Formulations, Preparations: ASAMID, ATYSMAL, CAPITUS, EMESIDE, For more Formulations, Preparations (Complete) data for ETHOSUXIMIDE (31 total), please visit the HSDB record page., U.S. Production: (1972) LESS THAN 10+7 GRAMS (CONSUMPTION EST), U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) No Data, General Manufacturing Information: US PATENT 2, 993, 835..
ethosuximide is a chemical compound with CAS registry number 77-67-8 and molecular formula C7H11NO2 (molecular weight 141.17).
CAS number: 77-67-8
Its molecular formula C7H11NO2 comprises 7 C, 11 H, 1 N, 2 O atoms.
Also known as: ethosuximide · 乙磺酰亚胺 · Petinimid
The CAS registry number of ethosuximide is 77-67-8.
Molecular formula C7H11NO2, molecular weight 141.17.
It is also registered under: ethosuximide, 乙磺酰亚胺, Petinimid.
Recorded applications: Uses: Antiepileptic, THERAP CAT: Anticonvulsant, MEDICATION, For the treatment of petit mal epilepsy., Use Classification: Pharmaceuticals, Methods of Manufacturing: The condensation of butanone with cyano ethyl acetate and subsequent reaction with NaCN and H2SO4 gives 2-ethyl-2-methyl-succinic acid, which is ring-closed via the diammonium salt to yield ethosuximide., Methyl ethyl ketone + ethyl cyanoacetate + hydrogen cyanide + ammonia (Cope reaction, addition, nitrile hydrolysis, decarboxylation, ester hydrolysis, amide formation), Formulations, Preparations: ASAMID, ATYSMAL, CAPITUS, EMESIDE, For more Formulations, Preparations (Complete) data for ETHOSUXIMIDE (31 total), please visit the HSDB record page., U.S. Production: (1972) LESS THAN 10+7 GRAMS (CONSUMPTION EST), U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) No Data, General Manufacturing Information: US PATENT 2, 993, 835..
Independent reference data for ethosuximide (CAS 77-67-8), compiled from public chemistry databases.
| CAS Registry Number | 77-67-8 |
|---|---|
| PubChem CID | 3291 |
| Molecular formula | C7H11NO2 |
| IUPAC name | 3-ethyl-3-methylpyrrolidine-2,5-dione |
| UNII (FDA) | 5SEH9X1D1D |
| Molecular Weight | 141.17 |
|---|---|
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 141.078978594 |
| Monoisotopic Mass | 141.078978594 |
| Topological Polar Surface Area | 46.2 |
| Heavy Atom Count | 10 |
| Melting Point | 64.5 |
|---|---|
| Melting Point | 64 - 65 °C |
| Melting Point | 64.5 °C |
| Solubility | 39.2 |
| Solubility | 1.01e+02 g/L |
| LogP | 0.38 |
| LogP | log Kow = 0.38 |
| LogP | 0.1 |
| LogP | 0.23 |
ethosuximide; 77-67-8; Zarontin; Etosuximida; 3-Ethyl-3-methylpyrrolidine-2,5-dione; 2-Ethyl-2-methylsuccinimide; Ethosuxide; Pyknolepsinum; Emeside; Suxilep; Ethosuccimide; Ethosuccinimide; Atysmal; Suxinutin; Etosuximid; Petinimid
| Reported hazard statements | H302 (95.7%) |
|---|
H302 (95.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Petinimid · CAS 77-67-8 · C7H11NO2. UNII 5SEH9X1D1D. Melting Point: 64.5; Melting Point: 64 - 65 °C; Melting Point: 64.5 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 乙磺酰亚胺