droperidol

Description

droperidol · CAS 548-73-2 · C22H22FN3O2. UNII O9U0F09D5X. Melting Point: 145-146.5; Melting Point: 145-146 °C; Melting Point: 145.75 °C.

Identification

CAS Registry Number	548-73-2
PubChem CID	3168
Molecular formula	C22H22FN3O2
IUPAC name	3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
UNII (FDA)	O9U0F09D5X

Computed Descriptors

Molecular Weight	379.4
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	379.16960512
Monoisotopic Mass	379.16960512
Topological Polar Surface Area	52.7
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Melting Point	145-146.5
Melting Point	145-146 °C
Melting Point	145.75 °C
Solubility	4.21
Solubility	9.66e-02 g/L
LogP	3.5
LogP	log Kow = 3.50
LogP	2.8
Dissociation Constants	7.6
Dissociation Constants	7.46

Physical description & handling notes

• Solid
• White to light tan, amorphous or microcrystalline powder
• Odorless
• Tasteless (no taste test is recommended)
• MP: 144-148 °C (after vacuum drying at 70 °C for 4 hr)
• 1 g soluble in 5.5 mL chloroform, 600 mL alcohol, 10,000 mL water; slightly soluble in ether

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• 4-Chloro-4'-fluorobutyrophenone is prepared from gamma-butyrolactone and reacted with 1-(1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone in presence of a suitable condensing agent.
• Droperidol is used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
• Breast Feeding; Lactation; Milk, Human; Antiemetics; Antipsychotic Agents; Butyrophenones; Dopamine Antagonists; Gastrointestinal Agents
• Adjuvants, Anesthesia; Antiemetics; Antipsychotic Agents; Dopamine Antagonists
• Droperidol Injection is indicated to reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures. /Included in US product label/

Synonyms

droperidol; 548-73-2; Droleptan; Dehydrobenzperidol; Inapsine; Dridol; Properidol; Sintodril; Sintosian; Halkan; Inapsin; Deidrobenzperidolo; Inopsin; McN-JR-4749; Droperidolo; Droperidolum

Frequently Asked Questions

What are the CAS number and molecular formula of droperidol?

CAS 548-73-2; molecular formula C22H22FN3O2; molecular weight — g/mol.

What other names is droperidol known by?

droperidol, 548-73-2, Droleptan, Dehydrobenzperidol, Inapsine, Dridol.

Is droperidol classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of droperidol?

Melting Point: 145-146.5; Melting Point: 145-146 °C; Melting Point: 145.75 °C; Solubility: 4.21.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.