多奈哌齐

Description

Donepezil · CAS 142057-79-2 · C24H29NO3. UNII 8SSC91326P. Boiling Point: 527.9; Melting Point: 223-227; Solubility: 31mg/mL.

Identification

CAS Registry Number	142057-79-2
PubChem CID	3152
Molecular formula	C24H29NO3
IUPAC name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
UNII (FDA)	8SSC91326P

Computed Descriptors

Molecular Weight	379.5
XLogP3	4.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	379.21474379
Monoisotopic Mass	379.21474379
Topological Polar Surface Area	38.8
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Boiling Point	527.9
Melting Point	223-227
Solubility	31mg/mL
LogP	4.7
LogP	4.11
Dissociation Constants	9.08
Dissociation Constants	8.9

Physical description & handling notes

• Solid
• 198.1 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 195.62 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 198.87 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Crystals from methanol/IPE; mw 415.95; mp 211-212 °C (decomposes) /Donepezil hydrochloride/
• White crystalline powder. Freely soluble in chloroform, soluble in water and glacial acetic acid, slightly soluble in ethanol and in acetonitrile and practically insoluble in ethyl acetate and in n-hexane. /Donezepil hydopchloride/

GHS Hazard Classification

Reported hazard statements	H300 (88.9%), H302 (11.1%), H315 (11.1%), H319 (22.2%), H335 (11.1%), H413 (11.1%)

Documented Uses

• ... in the treatment of Alzheimer's Disease
• ... has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.
• THERAP CAT: Nootropic /SRP: Memory or cognition enhancer/
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in the USA (2002): 0.00215

Synonyms

donepezil; 120014-06-4; donepezilo; Donaz; donepezilum; Domepezil; 8SSC91326P; D-797; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-; DTXSID8048317; CHEBI:53289; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-; donezpil hydrochloride; 5,6-dimethoxy-2-((1-(phenylmethyl)piperidin-4-yl)methyl)-2,3-dihydroinden-1-one; 5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one; donepezil hydrochlorid

Frequently Asked Questions

What are the CAS number and molecular formula of Donepezil?

CAS 142057-79-2; molecular formula C24H29NO3; molecular weight — g/mol.

What other names is Donepezil known by?

donepezil, 120014-06-4, donepezilo, Donaz, donepezilum, Domepezil.

Is Donepezil classified as hazardous?

Hazard statements reported: H300, H302, H315, H319, H335.

What are the key physical properties of Donepezil?

Boiling Point: 527.9; Melting Point: 223-227; Solubility: 31mg/mL; LogP: 4.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.