Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (CAS 75980-60-8) — formula C22H21O2P, molecular weight 348.4; category inorganic chemicals.
| CAS Number | 75980-60-8 |
|---|---|
| Molecular Formula | C22H21O2P |
| Molecular Weight | 348.4 |
| LogP | 5 |
| Applications | Uses: CIR ingredient: Trimethylbenzoyl Diphenylphosphine Oxide, Industry Uses: Not Known or Reasonably Ascertainable, Pigment, Photosensitive agent, Other, Tanning agents not otherwise specified, A 2021 review describes use as a photoinitiator in dental resin composites., Consumer Uses: Solvent, Photosensitizers, Not Known or Reasonably Ascertainable, The European Commission prohibited the use of TPO in cosmetic products beginning on September 1, 2025 (via the adoption of Commission Regulation (EU) 2025, 877). This was the result of TPO being classified as a CMR category 1B reproductive toxicant by Commission Delegated Regulation (EU) 2024, 197 under the CLP Regulation (Regulation (EC) No 1272, 2008), and this classification triggered the mandatory inclusion of TPO in Annex II (prohibited substances) of the Cosmetics Regulation via Regulation (EU) 2025, 877., Household Products: Cosmetics product ingredient: Diphenyl(2, 4, 6-trimethylbenzoyl)phosphine oxide (Trimethylbenzoyl diphenylphosphine oxide), Product count: 1, U.S. Production: 2023: 1, 000, 000 - <2, 500, 000 lb, 2022: 1, 2021: 1, 2020: 850, 000 - <1, General Manufacturing Information: Printing Ink Manufacturing, Miscellaneous Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Printing and Related Support Activities, Pharmaceutical and Medicine Manufacturing, Methanone, (diphenylphosphinyl)(2, 6-trimethylphenyl)-: ACTIVE |
| Category | Inorganic Chemicals |
Documented applications: Uses: CIR ingredient: Trimethylbenzoyl Diphenylphosphine Oxide, Industry Uses: Not Known or Reasonably Ascertainable, Pigment, Photosensitive agent, Other, Tanning agents not otherwise specified, A 2021 review describes use as a photoinitiator in dental resin composites., Consumer Uses: Solvent, Photosensitizers, Not Known or Reasonably Ascertainable, The European Commission prohibited the use of TPO in cosmetic products beginning on September 1, 2025 (via the adoption of Commission Regulation (EU) 2025, 877). This was the result of TPO being classified as a CMR category 1B reproductive toxicant by Commission Delegated Regulation (EU) 2024, 197 under the CLP Regulation (Regulation (EC) No 1272, 2008), and this classification triggered the mandatory inclusion of TPO in Annex II (prohibited substances) of the Cosmetics Regulation via Regulation (EU) 2025, 877., Household Products: Cosmetics product ingredient: Diphenyl(2, 4, 6-trimethylbenzoyl)phosphine oxide (Trimethylbenzoyl diphenylphosphine oxide), Product count: 1, U.S. Production: 2023: 1, 000, 000 - <2, 500, 000 lb, 2022: 1, 2021: 1, 2020: 850, 000 - <1, General Manufacturing Information: Printing Ink Manufacturing, Miscellaneous Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Printing and Related Support Activities, Pharmaceutical and Medicine Manufacturing, Methanone, (diphenylphosphinyl)(2, 6-trimethylphenyl)-: ACTIVE.
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is an inorganic compound with CAS registry number 75980-60-8 and molecular formula C22H21O2P (molecular weight 348.4), belonging to the inorganic chemicals segment of chemical raw materials.
CAS number: 75980-60-8
Its molecular formula C22H21O2P comprises 22 C, 21 H, 2 O, 1 P atoms.
Also known as: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide · 二苯基(2,4,6-三甲基苯甲酰基)氧化膦
Category: inorganic chemicals
The CAS registry number of Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is 75980-60-8.
Molecular formula C22H21O2P, molecular weight 348.4.
It is also registered under: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide, 二苯基(2,4,6-三甲基苯甲酰基)氧化膦.
Recorded applications: Uses: CIR ingredient: Trimethylbenzoyl Diphenylphosphine Oxide, Industry Uses: Not Known or Reasonably Ascertainable, Pigment, Photosensitive agent, Other, Tanning agents not otherwise specified, A 2021 review describes use as a photoinitiator in dental resin composites., Consumer Uses: Solvent, Photosensitizers, Not Known or Reasonably Ascertainable, The European Commission prohibited the use of TPO in cosmetic products beginning on September 1, 2025 (via the adoption of Commission Regulation (EU) 2025, 877). This was the result of TPO being classified as a CMR category 1B reproductive toxicant by Commission Delegated Regulation (EU) 2024, 197 under the CLP Regulation (Regulation (EC) No 1272, 2008), and this classification triggered the mandatory inclusion of TPO in Annex II (prohibited substances) of the Cosmetics Regulation via Regulation (EU) 2025, 877., Household Products: Cosmetics product ingredient: Diphenyl(2, 4, 6-trimethylbenzoyl)phosphine oxide (Trimethylbenzoyl diphenylphosphine oxide), Product count: 1, U.S. Production: 2023: 1, 000, 000 - <2, 500, 000 lb, 2022: 1, 2021: 1, 2020: 850, 000 - <1, General Manufacturing Information: Printing Ink Manufacturing, Miscellaneous Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Printing and Related Support Activities, Pharmaceutical and Medicine Manufacturing, Methanone, (diphenylphosphinyl)(2, 6-trimethylphenyl)-: ACTIVE.
Category: Inorganic Chemicals.
Independent reference data for Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (CAS 75980-60-8), compiled from public chemistry databases.
| CAS Registry Number | 75980-60-8 |
|---|---|
| PubChem CID | 166480 |
| Molecular formula | C22H21O2P |
| IUPAC name | diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone |
| UNII (FDA) | B9EIM2D97X |
| Molecular Weight | 348.4 |
|---|---|
| XLogP3 | 5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 348.12791691 |
| Monoisotopic Mass | 348.12791691 |
| Topological Polar Surface Area | 34.1 |
| Heavy Atom Count | 25 |
| Vapor Pressure | 3.045 x 10-6 Pa at 25 degrees C |
|---|---|
| pH | 4 to 5 |
75980-60-8; Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide; Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-; DTXSID4052502; EINECS 278-355-8; B9EIM2D97X; 2,4,6-trimethylbenzoyl diphenylphosphine oxide; trimethylbenzoyl diphenylphosphine oxide; CHIVACURE TPO; DOUBLECURE TPO; ADDITOL TPO; GENOCURE TPO; Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)-; DTXCID8031075; EC 278-355-8; (2,4,6-trimethylbenzoyl)diphenylphosphine oxide
| Regulatory & Food Contact | CIR / INCI: Cosmetic ingredients (Trimethylbenzoyl Diphenylphosphine Oxide) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS notification summary | 0.4% (13 / 3088) |
| GHS notification summary | 0.4% (13 / 3088) |
|---|---|
| Reported hazard statements | H317, H361 (95.3%), H411 (87%) |
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
H360Fd: May damage fertility; Suspected of damaging the unborn child [Danger Reproductive toxicity]
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide · CAS 75980-60-8 · C22H21O2P. UNII B9EIM2D97X. Vapor Pressure: 3.045 x 10-6 Pa at 25 degrees C; pH: 4 to 5.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 二苯基(2,4,6-三甲基苯甲酰基)氧化膦