二甲基甲酰胺（CAS 68-12-2）：分子式 C3H7NO、分子量 73.09。
| CAS号 | 68-12-2 |
|---|---|
| 分子式 | C3H7NO |
| 分子量 | 73.09 |
| 熔点 | -78 °F (NTP, 1992) |
| 沸点 | 300 to 313 °F at 760 mmHg (NTP, 1992) |
| LogP | -1 |
| 应用领域 | Uses: Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used to process polymer fibers、films、and surface coatings、to permit easy spinning of acrylic fibers、to produce wire enamels、and as a crystallization medium in the pharmaceutical industry.、Used as a solvent in acrylic fiber spinning、textile dyeing、and paint stripping、also used in coating、printing、gluing、and pharmaceutical manufacturing、[http:、www.cdc.gov、niosh、90-105.html] Used as a solvent for vinyl resins、[Kanerva、p. 1786] Used in synthetic leather manufacturing、[JOEM 2004、46:729-736]、Semiconductor Manufacturing [Category: Industry]、Textiles (Fiber & Fabric Manufacturing) [Category: Industry]、Painting (Solvents) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Plastic Composites Manufacturing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For N、N-Dimethylformamide (USEPA、OPP Pesticide Code: 366200) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ... In addition DMF is used as a solvent in the preparation of high quality surfaces based on polyurethanes、which are otherwise difficult to solubilize、and it is employed as a solvent for coating surfaces with polyamides.、Solvent for liquids and gases. ... Solvent for Orlon and similar polyacrylic fibers. ...、Used、wherever a solvent with a slow rate of evaporation is needed.、Pharmaceutical processing and acrylic fiber production、reaction and crystallizing solvent、solvent for depositing polyurethane coatings on leather and artificial leather fabrics、separation of aliphatic hydrocarbons、recovery of CO2 in flue gases、quencher and cleaner of hot-dip tinned parts、used in high voltage capacitors、industrial paint stripping applications、solvent、reagent、and catalyst in organic chemistry、For more Uses (Complete) data for N、N-DIMETHYLFORMAMIDE (6 total)、please visit the HSDB record page.、Dimethyl formamide (DMF) is commonly used as a solvent for chemical reactions. (L1658)、Use Classification: SOLVENTS、Industry Uses: pH regulating agent、Fuel agents、Semiconductor and photovoltaic agent、Tanning agents not otherwise specified、Solvent、Intermediate、Not Known or Reasonably Ascertainable、Catalyst、Soil amendments (fertilizers)、Stabilizing agent、Cleaning agent、Consumer Uses: Cleaning agent、Methods of Manufacturing: The direct or one-step synthesis of DMF begins with either pure carbon monoxide or a gas stream containing carbon monoxide. This is reacted in a continuous process with N、N-dimethylamine、by using a solution of alkali alkoxide (usually sodium methoxide) in methanol as catalyst. Methyl formate is presumably formed as an intermediate. The reaction mixture passes over an external heat exchanger to remove the excess heat generated and to ensure thorough mixing of the components. The reaction is conducted between 0.5 and 11 MPa at 50 - 200 °C. The reaction mixture exits the reactor through a decompression chamber. In addition to N、N-dimethylformamide、the crude product contains methanol、a certain amount of unreacted N、dissolved carbon monoxide、and residual catalyst. The addition of acid or water deactivates any catalyst present、resulting in the formation of sodium formate. Dissolved carbon monoxide、together with inert gases、escapes from the mixture during decompression、and the off-gases are removed by combustion. Preliminary distillation is followed by a second distillation in a separate column、here、dimethylformamide is separated from methanol which contains traces of N、N-dimethylamine. Further distillation results in a product of 99.9%purity.、The two-step process for the synthesis of N、N-dimethylformamide differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercial-grade) material. Equimolar amounts of methyl formate and N、N-dimethylamine are subjected to a continuous reaction at 60 - 100 °C and 0.1 - 0.3 MPa. The resulting product is a mixture of N、N-dimethylformamide and methanol. The purification process involves distillation ... No separation of salts is required because no catalysts are involved in the process. According to the corrosive properties of both starting materials and products、stainless steel has to be used as material of construction for production facilities.、Reaction of methyl formate with dimethylamine.、Manufactured by the reaction of CO and dimethylamine. The reaction is carried out in the liquid phase using a sodium methoxide catalyst at 110-120 °C and 350 kPa (3.5 atm).、Impurities: Water (0.05%)、dimethylamine (15 ppm)、formic acid (20 ppm)、iron (0.05 ppm)、U.S. Production: 2023: 85、000、000 - <100、000 lb、2022: 70、000 - <85、2021: 55、000 - <70、2020: 40、000 - <55、(1972) PROBABLY GREATER THAN 4.54X10+5 G、(1991) 25、000 tons、N、N-Dimethyformmide is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#218]、For more U.S. Production (Complete) data for N、N-DIMETHYLFORMAMIDE (7 total)、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Utilities、Agriculture、Forestry、Fishing and Hunting、Electrical Equipment、Appliance、and Component Manufac |
登记用途：Uses: Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used to process polymer fibers、films、and surface coatings、to permit easy spinning of acrylic fibers、to produce wire enamels、and as a crystallization medium in the pharmaceutical industry.、Used as a solvent in acrylic fiber spinning、textile dyeing、and paint stripping、also used in coating、printing、gluing、and pharmaceutical manufacturing、[http:、www.cdc.gov、niosh、90-105.html] Used as a solvent for vinyl resins、[Kanerva、p. 1786] Used in synthetic leather manufacturing、[JOEM 2004、46:729-736]、Semiconductor Manufacturing [Category: Industry]、Textiles (Fiber & Fabric Manufacturing) [Category: Industry]、Painting (Solvents) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Plastic Composites Manufacturing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For N、N-Dimethylformamide (USEPA、OPP Pesticide Code: 366200) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ... In addition DMF is used as a solvent in the preparation of high quality surfaces based on polyurethanes、which are otherwise difficult to solubilize、and it is employed as a solvent for coating surfaces with polyamides.、Solvent for liquids and gases. ... Solvent for Orlon and similar polyacrylic fibers. ...、Used、wherever a solvent with a slow rate of evaporation is needed.、Pharmaceutical processing and acrylic fiber production、reaction and crystallizing solvent、solvent for depositing polyurethane coatings on leather and artificial leather fabrics、separation of aliphatic hydrocarbons、recovery of CO2 in flue gases、quencher and cleaner of hot-dip tinned parts、used in high voltage capacitors、industrial paint stripping applications、solvent、reagent、and catalyst in organic chemistry、For more Uses (Complete) data for N、N-DIMETHYLFORMAMIDE (6 total)、please visit the HSDB record page.、Dimethyl formamide (DMF) is commonly used as a solvent for chemical reactions. (L1658)、Use Classification: SOLVENTS、Industry Uses: pH regulating agent、Fuel agents、Semiconductor and photovoltaic agent、Tanning agents not otherwise specified、Solvent、Intermediate、Not Known or Reasonably Ascertainable、Catalyst、Soil amendments (fertilizers)、Stabilizing agent、Cleaning agent、Consumer Uses: Cleaning agent、Methods of Manufacturing: The direct or one-step synthesis of DMF begins with either pure carbon monoxide or a gas stream containing carbon monoxide. This is reacted in a continuous process with N、N-dimethylamine、by using a solution of alkali alkoxide (usually sodium methoxide) in methanol as catalyst. Methyl formate is presumably formed as an intermediate. The reaction mixture passes over an external heat exchanger to remove the excess heat generated and to ensure thorough mixing of the components. The reaction is conducted between 0.5 and 11 MPa at 50 - 200 °C. The reaction mixture exits the reactor through a decompression chamber. In addition to N、N-dimethylformamide、the crude product contains methanol、a certain amount of unreacted N、dissolved carbon monoxide、and residual catalyst. The addition of acid or water deactivates any catalyst present、resulting in the formation of sodium formate. Dissolved carbon monoxide、together with inert gases、escapes from the mixture during decompression、and the off-gases are removed by combustion. Preliminary distillation is followed by a second distillation in a separate column、here、dimethylformamide is separated from methanol which contains traces of N、N-dimethylamine. Further distillation results in a product of 99.9%purity.、The two-step process for the synthesis of N、N-dimethylformamide differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercial-grade) material. Equimolar amounts of methyl formate and N、N-dimethylamine are subjected to a continuous reaction at 60 - 100 °C and 0.1 - 0.3 MPa. The resulting product is a mixture of N、N-dimethylformamide and methanol. The purification process involves distillation ... No separation of salts is required because no catalysts are involved in the process. According to the corrosive properties of both starting materials and products、stainless steel has to be used as material of construction for production facilities.、Reaction of methyl formate with dimethylamine.、Manufactured by the reaction of CO and dimethylamine. The reaction is carried out in the liquid phase using a sodium methoxide catalyst at 110-120 °C and 350 kPa (3.5 atm).、Impurities: Water (0.05%)、dimethylamine (15 ppm)、formic acid (20 ppm)、iron (0.05 ppm)、U.S. Production: 2023: 85、000、000 - <100、000 lb、2022: 70、000 - <85、2021: 55、000 - <70、2020: 40、000 - <55、(1972) PROBABLY GREATER THAN 4.54X10+5 G、(1991) 25、000 tons、N、N-Dimethyformmide is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#218]、For more U.S. Production (Complete) data for N、N-DIMETHYLFORMAMIDE (7 total)、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Utilities、Agriculture、Forestry、Fishing and Hunting、Electrical Equipment、Appliance、and Component Manufac。
二甲基甲酰胺 是一种化工化合物，登记 CAS 号为 68-12-2，分子式 C3H7NO（分子量 73.09）。
登记 CAS 号：68-12-2
其分子式 C3H7NO 由 3 个碳、7 个氢、1 个氮、1 个氧 组成。
别名/同义词：二甲基甲酰胺 · Dimethylformamide · Dimethyl Formamide (DMF)
二甲基甲酰胺 的 CAS 登记号为 68-12-2。
分子式 C3H7NO，分子量 73.09。
别名/同义词：二甲基甲酰胺、Dimethylformamide、Dimethyl Formamide (DMF)。
登记用途：Uses: Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used to process polymer fibers、films、and surface coatings、to permit easy spinning of acrylic fibers、to produce wire enamels、and as a crystallization medium in the pharmaceutical industry.、Used as a solvent in acrylic fiber spinning、textile dyeing、and paint stripping、also used in coating、printing、gluing、and pharmaceutical manufacturing、[http:、www.cdc.gov、niosh、90-105.html] Used as a solvent for vinyl resins、[Kanerva、p. 1786] Used in synthetic leather manufacturing、[JOEM 2004、46:729-736]、Semiconductor Manufacturing [Category: Industry]、Textiles (Fiber & Fabric Manufacturing) [Category: Industry]、Painting (Solvents) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Plastic Composites Manufacturing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For N、N-Dimethylformamide (USEPA、OPP Pesticide Code: 366200) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The most important use of DMF as a solvent for polymers is in the preparation of polyacrylonitrile solutions for the manufacture of fibrous polyacrylonitrile ... In addition DMF is used as a solvent in the preparation of high quality surfaces based on polyurethanes、which are otherwise difficult to solubilize、and it is employed as a solvent for coating surfaces with polyamides.、Solvent for liquids and gases. ... Solvent for Orlon and similar polyacrylic fibers. ...、Used、wherever a solvent with a slow rate of evaporation is needed.、Pharmaceutical processing and acrylic fiber production、reaction and crystallizing solvent、solvent for depositing polyurethane coatings on leather and artificial leather fabrics、separation of aliphatic hydrocarbons、recovery of CO2 in flue gases、quencher and cleaner of hot-dip tinned parts、used in high voltage capacitors、industrial paint stripping applications、solvent、reagent、and catalyst in organic chemistry、For more Uses (Complete) data for N、N-DIMETHYLFORMAMIDE (6 total)、please visit the HSDB record page.、Dimethyl formamide (DMF) is commonly used as a solvent for chemical reactions. (L1658)、Use Classification: SOLVENTS、Industry Uses: pH regulating agent、Fuel agents、Semiconductor and photovoltaic agent、Tanning agents not otherwise specified、Solvent、Intermediate、Not Known or Reasonably Ascertainable、Catalyst、Soil amendments (fertilizers)、Stabilizing agent、Cleaning agent、Consumer Uses: Cleaning agent、Methods of Manufacturing: The direct or one-step synthesis of DMF begins with either pure carbon monoxide or a gas stream containing carbon monoxide. This is reacted in a continuous process with N、N-dimethylamine、by using a solution of alkali alkoxide (usually sodium methoxide) in methanol as catalyst. Methyl formate is presumably formed as an intermediate. The reaction mixture passes over an external heat exchanger to remove the excess heat generated and to ensure thorough mixing of the components. The reaction is conducted between 0.5 and 11 MPa at 50 - 200 °C. The reaction mixture exits the reactor through a decompression chamber. In addition to N、N-dimethylformamide、the crude product contains methanol、a certain amount of unreacted N、dissolved carbon monoxide、and residual catalyst. The addition of acid or water deactivates any catalyst present、resulting in the formation of sodium formate. Dissolved carbon monoxide、together with inert gases、escapes from the mixture during decompression、and the off-gases are removed by combustion. Preliminary distillation is followed by a second distillation in a separate column、here、dimethylformamide is separated from methanol which contains traces of N、N-dimethylamine. Further distillation results in a product of 99.9%purity.、The two-step process for the synthesis of N、N-dimethylformamide differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercial-grade) material. Equimolar amounts of methyl formate and N、N-dimethylamine are subjected to a continuous reaction at 60 - 100 °C and 0.1 - 0.3 MPa. The resulting product is a mixture of N、N-dimethylformamide and methanol. The purification process involves distillation ... No separation of salts is required because no catalysts are involved in the process. According to the corrosive properties of both starting materials and products、stainless steel has to be used as material of construction for production facilities.、Reaction of methyl formate with dimethylamine.、Manufactured by the reaction of CO and dimethylamine. The reaction is carried out in the liquid phase using a sodium methoxide catalyst at 110-120 °C and 350 kPa (3.5 atm).、Impurities: Water (0.05%)、dimethylamine (15 ppm)、formic acid (20 ppm)、iron (0.05 ppm)、U.S. Production: 2023: 85、000、000 - <100、000 lb、2022: 70、000 - <85、2021: 55、000 - <70、2020: 40、000 - <55、(1972) PROBABLY GREATER THAN 4.54X10+5 G、(1991) 25、000 tons、N、N-Dimethyformmide is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#218]、For more U.S. Production (Complete) data for N、N-DIMETHYLFORMAMIDE (7 total)、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Utilities、Agriculture、Forestry、Fishing and Hunting、Electrical Equipment、Appliance、and Component Manufac。
二甲基甲酰胺（CAS 68-12-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 68-12-2 |
|---|---|
| PubChem CID | 6228 |
| Molecular formula | C3H7NO |
| IUPAC name | N,N-dimethylformamide |
| UNII (FDA) | 8696NH0Y2X |
| Molecular Weight | 73.09 |
|---|---|
| XLogP3 | -1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 73.052763847 |
| Monoisotopic Mass | 73.052763847 |
| Topological Polar Surface Area | 20.3 |
| Heavy Atom Count | 5 |
| Boiling Point | 300 to 313 °F at 760 mmHg (NTP, 1992) |
|---|---|
| Boiling Point | 153 |
| Boiling Point | 152.8 °C |
| Boiling Point | BP: 76 °C at 39 mm Hg; 25 °C at 3.7 mm Hg |
| Boiling Point | 153 °C |
| Boiling Point | 307 °F |
| Boiling Point | 153 °C @760 [mm Hg] |
| Melting Point | -78 °F (NTP, 1992) |
| Melting Point | -60.4 |
| Melting Point | -60.3 °C |
N,N-DIMETHYLFORMAMIDE; Dimethylformamide; 68-12-2; Dimethyl formamide; N-Formyldimethylamine; Formamide, N,N-dimethyl-; Dimethylformamid; DMFA; N,N-Dimethyl formamide; Formyldimethylamine; Dimetilformamide; Dwumetyloformamid; Dimetylformamidu; DMF (amide); NCI-C60913; DTXSID6020515
| Regulatory & Food Contact | FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS |
|---|---|
| GHS notification summary | 0.1% (1 / 1434) |
| GHS notification summary | 0.1% (1 / 1434) |
|---|---|
| Reported hazard statements | H312, H319, H332, H226 (33.5%), H360 (93.5%), H315, H331, H350 |
H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Dimethyl Formamide (DMF) · CAS 68-12-2 · C3H7NO. UNII 8696NH0Y2X. Boiling Point: 300 to 313 °F at 760 mmHg (NTP, 1992); Boiling Point: 153; Boiling Point: 152.8 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Dimethylformamide