Dicyclohexylcarbodiimide

Independent reference data for Dicyclohexylcarbodiimide (CAS 538-75-0), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

Used in chemical synthesis; [Hawley] Used as a coupling reagent in peptide chemistry; [Kanerva, p. 1781]Dicyclohexylcarbodiimide is used in industry as a stabilizing agent, coupling agent, and condensing agent. It has widespread use during protein synthesis in the recombinant DNA industry and in the synthesis of polypeptides in the chemical and pharmaceutical industries.[DHHS/NTP; Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified

Synonyms and trade names

DICYCLOHEXYLCARBODIIMIDE; 538-75-0; N,N'-Dicyclohexylcarbodiimide; 1,3-Dicyclohexylcarbodiimide; DCCD; DCCI; Carbodicyclohexylimide; Bis(cyclohexyl)carbodiimide; Carbodiimide, dicyclohexyl-; Cyclohexanamine, N,N'-methanetetraylbis-; dicyclohexylmethanediimine; N,N'-Methanetetraylbiscyclohexaamine; DTXSID1023817; Dicyclohexyl-Carbodiimide; CHEBI:53090; NSC-30022

GHS hazard classification

Reported hazard statements	H302, H311, H317, H318, H315 (20.6%), H400 (14.5%), H410 (14.9%), H413 (20.6%)

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

What the public record says

Dicyclohexylcarbodiimide · CAS 538-75-0 · C13H22N2. UNII 0T1427205E. Boiling Point: 252 to 255 °F at 6 mmHg (NTP, 1992); Boiling Point: BP: 154-156 °C at 11 mm Hg; Melting Point: 93 to 95 °F (NTP, 1992).

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.