达洛鲁胺

达洛鲁胺（CAS 1297538-32-9）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Darolutamide is indicated for the treatment of adults with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-sensitive prostate cancer (mCSPC), either as monotherapy or in combination with docetaxel.Darolutamide is a third generation, oral nonsteroidal antiandrogen used to treat nonmetastatic castration-resistant prostate cancer. Darolutamide is associated with a low rate of serum enzyme elevation during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.

同义词与商品名

Darolutamide; 1297538-32-9; ODM-201; Nubeqa; BAY1841788; BAY-1841788; darolutamida; X05U0N2RCO; BAY 1841788; N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; DTXSID101027953; darolutamidum; N-((2S)-1-(3-(3-chloro-4-cyanophenyl)pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; Antiandrogen ODM-201; RefChem:58141; L02BB06

GHS 危害分类

Reported hazard statements	H302 (100%), H400 (100%), H410 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

公开数据库对它的描述

Darolutamide · CAS 1297538-32-9 · C19H19ClN6O2. UNII X05U0N2RCO. Boiling Point: 719.5±60.0; LogP: 1.904; Dissociation Constants: 11.75.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。