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Darolutamide

CAS 1297538-32-9C19H19ClN6O2MW 398.8

Darolutamide (CAS 1297538-32-9) — formula C19H19ClN6O2, molecular weight 398.8.

Product Overview

CAS Number1297538-32-9
Molecular FormulaC19H19ClN6O2
Molecular Weight398.8
Boiling Point719.5±60.0
LogP1.904

Technical Profile

What this product is

Darolutamide is a chemical compound with CAS registry number 1297538-32-9 and molecular formula C19H19ClN6O2 (molecular weight 398.8).

Identification

CAS number: 1297538-32-9

Its molecular formula C19H19ClN6O2 comprises 19 C, 19 H, 1 Cl, 6 N, 2 O atoms.

Also known as: Darolutamide · 达洛鲁胺

Frequently Asked Questions

What is the CAS number of Darolutamide?

The CAS registry number of Darolutamide is 1297538-32-9.

What is the molecular formula and molecular weight of Darolutamide?

Molecular formula C19H19ClN6O2, molecular weight 398.8.

What other names is Darolutamide known by?

It is also registered under: Darolutamide, 达洛鲁胺.

PubChem Public Data

Independent reference data for Darolutamide (CAS 1297538-32-9), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number1297538-32-9
PubChem CID67171867
Molecular formulaC19H19ClN6O2
IUPAC nameN-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
UNII (FDA)X05U0N2RCO

Computed descriptors

Molecular Weight398.8
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass398.1258016
Monoisotopic Mass398.1258016
Topological Polar Surface Area120
Heavy Atom Count28

Physicochemical values on record

Boiling Point719.5±60.0
LogP1.904
Dissociation Constants11.75

Documented uses on record

    Darolutamide is indicated for the treatment of adults with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-sensitive prostate cancer (mCSPC), either as monotherapy or in combination with docetaxel.Darolutamide is a third generation, oral nonsteroidal antiandrogen used to treat nonmetastatic castration-resistant prostate cancer. Darolutamide is associated with a low rate of serum enzyme elevation during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.

    Synonyms and trade names

    Darolutamide; 1297538-32-9; ODM-201; Nubeqa; BAY1841788; BAY-1841788; darolutamida; X05U0N2RCO; BAY 1841788; N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; DTXSID101027953; darolutamidum; N-((2S)-1-(3-(3-chloro-4-cyanophenyl)pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide; Antiandrogen ODM-201; RefChem:58141; L02BB06

    GHS hazard classification

    Reported hazard statementsH302 (100%), H400 (100%), H410 (100%)

    H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

    H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

    What the public record says

    Darolutamide · CAS 1297538-32-9 · C19H19ClN6O2. UNII X05U0N2RCO. Boiling Point: 719.5±60.0; LogP: 1.904; Dissociation Constants: 11.75.

    Physical description and handling notes

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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