cysteamine

Description

cysteamine · CAS 60-23-1 · C2H7NS. UNII 5UX2SD1KE2. Boiling Point: 133.6±23.0; Melting Point: 67-71; Melting Point: 97-98.5 °C.

Identification

CAS Registry Number	60-23-1
PubChem CID	6058
Molecular formula	C2H7NS
IUPAC name	2-aminoethanethiol
UNII (FDA)	5UX2SD1KE2

Computed Descriptors

Molecular Weight	77.15
XLogP3	-0.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	77.02992040
Monoisotopic Mass	77.02992040
Topological Polar Surface Area	27
Heavy Atom Count	4
Formal Charge	0

Physical & Chemical Properties

Boiling Point	133.6±23.0
Melting Point	67-71
Melting Point	97-98.5 °C
Melting Point	98 °C
LogP	0.1
Dissociation Constants	10.4

Physical description & handling notes

• Solid
• Crystals by sublimation in vacuo
• Crystals from alcohol
• Disagreeable odor
• Decomposes
• Freely soluble in water.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (97.6%), H317, H318, H402, H412

Documented Uses

• Therap Cat: Antidote to acetaminophen /SRP: former/
• Experimentally as a radioprotective agent and to produce acute and chronic duodenal ulcers in rats.
• Use (kg; approx.) in Germany (2009): >50
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• The bitartrate salt of cysteamine is used for the oral treatment of nephropathic cystinosis and cystinuria in adults and in children aged ≥6 years. The hydrochloride salt, formulated as ophthalmic drops, is indicated for the treatment of corneal cystine crystal accumulation in patients with cystinosis. Approved by the EMA for the treatment of corneal cystine crystal accumulation in adults and in children aged ≥6 months with cystinosis
• Cysteamine is a simple aminothiol molecule that is used to treat nephropathic cystinosis, due to its ability to decrease the markedly elevated and toxic levels of intracellular cystine that occur in this disease and cause its major complications. Cysteamine has been associated with serum enzyme elevations when given intravenously in high doses, but it has not been shown to cause clinically apparent acute liver injury.

Synonyms

CYSTEAMINE; 2-Aminoethanethiol; 60-23-1; Mercaptamine; Thioethanolamine; 2-Mercaptoethylamine; Mercamine; beta-Mercaptoethylamine; Decarboxycysteine; Cysteinamine; 2-Amino-1-ethanethiol; beta-Aminoethanethiol; Ethanethiol, 2-amino-; Mercaptoethylamine; 2-Mercaptoethanamine; beta-Aminoethylthiol

Frequently Asked Questions

What are the CAS number and molecular formula of cysteamine?

CAS 60-23-1; molecular formula C2H7NS; molecular weight — g/mol.

What other names is cysteamine known by?

CYSTEAMINE, 2-Aminoethanethiol, 60-23-1, Mercaptamine, Thioethanolamine, 2-Mercaptoethylamine.

Is cysteamine classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H317.

What are the key physical properties of cysteamine?

Boiling Point: 133.6±23.0; Melting Point: 67-71; Melting Point: 97-98.5 °C; Melting Point: 98 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.