clofibrate

Description

clofibrate · CAS 637-07-0 · C12H15ClO3. UNII HPN91K7FU3. Boiling Point: 149; Boiling Point: 148-150 °C @ 20 MM HG; Melting Point: 118-119.

Identification

CAS Registry Number	637-07-0
PubChem CID	2796
Molecular formula	C12H15ClO3
IUPAC name	ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
UNII (FDA)	HPN91K7FU3

Computed Descriptors

Molecular Weight	242.70
XLogP3	3.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	242.0709720
Monoisotopic Mass	242.0709720
Topological Polar Surface Area	35.5
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Boiling Point	149
Boiling Point	148-150 °C @ 20 MM HG
Melting Point	118-119
Melting Point	< 25 °C
Solubility	2.90e-02 g/L
Density	1.138-1.144 @ 20 °C
LogP	3.3
LogP	3.39

Physical description & handling notes

• Solid
• OIL
• COLORLESS TO PALE YELLOW LIQ
• FAINT CHARACTERISTIC ODOR
• FAINT CHARACTERISTIC TASTE
• Insoluble

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (97.6%), H318 (97.6%), H335 (97.6%)

Documented Uses

• AGENT TO LOWER PLASMA VERY-LOW-DENSITY-LIPOPROTEIN CONCN; AGENT TO LOWER CONCN OF PLASMA TRIGLYCERIDES
• For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet. This helps control high cholesterol and high triglyceride levels.
• CONDENSATION OF PHENOL WITH ETHYL 2-CHLORO-2-METHYLPROPIONATE IN PRESENCE OF A DEHYDROCHLORINATING AGENT, FOLLOWED BY CHLORINATION AND PURIFICATION
• Synthesized by the condensation of p-chlorophenol with acetone and chloroform and the resultant acid is esterified to give clofibrate.
• ESSENTIALLY 100% AS A MEDICINAL (ANTICHOLESTEREMIC) (1976)
• (1972) PROBABLY LESS THAN 4.54X10+5 GRAMS

Synonyms

clofibrate; 637-07-0; Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate; Ethyl clofibrate; Atromid-S; Ateriosan; Clofibrato; Amotril; Liprin; EPIB; Atheropront; Clofibratum; Anparton; Ateculon; Cartagyl; Lipavil

Frequently Asked Questions

What are the CAS number and molecular formula of clofibrate?

CAS 637-07-0; molecular formula C12H15ClO3; molecular weight — g/mol.

What other names is clofibrate known by?

clofibrate, 637-07-0, Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, Ethyl clofibrate, Atromid-S, Ateriosan.

Is clofibrate classified as hazardous?

Hazard statements reported: H302, H315, H318, H335.

What are the key physical properties of clofibrate?

Boiling Point: 149; Boiling Point: 148-150 °C @ 20 MM HG; Melting Point: 118-119; Melting Point: < 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.