大黄酚

Description

Chrysophanol · CAS 481-74-3 · C15H10O4. UNII N1ST8V8RR2. Melting Point: 196 °C; Melting Point: 200 - 201 °C; Density: 0.92 g/cm cu at 25 °C.

Identification

CAS Registry Number	481-74-3
PubChem CID	10208
Molecular formula	C15H10O4
IUPAC name	1,8-dihydroxy-3-methylanthracene-9,10-dione
UNII (FDA)	N1ST8V8RR2

Computed Descriptors

Molecular Weight	254.24
XLogP3	3.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	254.05790880
Monoisotopic Mass	254.05790880
Topological Polar Surface Area	74.6
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	196 °C
Melting Point	200 - 201 °C
Density	0.92 g/cm cu at 25 °C
LogP	4.39

Physical description & handling notes

• Chrysophanic acid appears as golden yellow plates or brown powder. Melting point 196 °C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red. (NTP, 1992)
• Solid
• Yellow hexagonal or monoclinic needles
• Crystalline; dark yellow
• Sublimes
• 385 °F (sublimes) (NTP, 1992)

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (11.4%)

Documented Uses

• Laboratory chemicals, manufacture of substances
• Traditional Medicine (ingredient)
• Occurs in the free state and as glucoside in cascara sarada, senna and various species of Rumex and Rheum (rhubarb).
• /EXPL THER/ Endoplasmic reticulum (ER) stress plays a critical role in mediating ischemia/reperfusion (I/R) damage in the brain. Our previous study showed that Chrysophanol (CHR) alleviated cerebral ischemic injury in mice and nuclear factor-kappaB (NF-kappaB) involved in its neuroprotective effect, but the precise mechanism remains not fully understood. The present study investigated the effect of CHR treatment on I/R-induced ER stress. Mice were subjected to middle cerebral artery occlusion (MCAO) for 45 min and
• For more Therapeutic Uses (Complete) data for Chrysophanic acid (12 total), please visit the HSDB record page.
• Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

Synonyms

Chrysophanol; CHRYSOPHANIC ACID; 481-74-3; 1,8-dihydroxy-3-methylanthracene-9,10-dione; 3-Methylchrysazin; 1,8-Dihydroxy-3-methylanthraquinone; 1,8-Dihydroxy-3-methyl-9,10-anthracenedione; C.I. Natural Yellow 23; 4,5-Dihydroxy-2-methylanthraquinone; 3-Methyl-1,8-dihydroxyanthraquinone; 2-Methyl-4,5-dihydroxyanthraquinone; C.I. 75400; DTXSID6024832; 1,8-dihydroxy-3-methyl-9,10-anthraquinone; N1ST8V8RR2; NSC-37132

Frequently Asked Questions

What are the CAS number and molecular formula of Chrysophanol?

CAS 481-74-3; molecular formula C15H10O4; molecular weight — g/mol.

What other names is Chrysophanol known by?

Chrysophanol, CHRYSOPHANIC ACID, 481-74-3, 1,8-dihydroxy-3-methylanthracene-9,10-dione, 3-Methylchrysazin, 1,8-Dihydroxy-3-methylanthraquinone.

Is Chrysophanol classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of Chrysophanol?

Melting Point: 196 °C; Melting Point: 200 - 201 °C; Density: 0.92 g/cm cu at 25 °C; LogP: 4.39.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.