chloroquine

CAS 54-05-7C18H26ClN3MW 319.9

chloroquine (CAS 54-05-7) — formula C18H26ClN3, molecular weight 319.9.

Product Overview

CAS Number	54-05-7
Molecular Formula	C18H26ClN3
Molecular Weight	319.9
Melting Point	87-89.5
LogP	4.63
Applications	Uses: MEDICATION, Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant, Mesh Heading: Amebicides, antimalarials, antirheumatic Agents, Use (kg, approx.) in Germany (2009): >750, Consumption (g per capita, approx.) in Germany (2009): 0.00916, Excretion rate: 0.7, Calculated removal (%): 78.6, For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: H. Andersag et al., US 2233970 (1941 to Winthrop), Condensation of 4, 7-dichloroquinoline with 1-diethylamino-4-aminopentane: German patent 683692 (1939), Formulations, Preparations: Chloroquine phosphate, USP ... is available as tablets containing either 250 or 500 mg of diphosphate. Approximately 60% of diphosphate represents base., Chloroquine phosphate, Arechin, Avloclor, Imagon, Malaquin, Resochin, Tresochin., Chloroquine diphosphate, Nivaquine., Chloroquine Sulfate, Tablets (as the phosphate), 500 mg. Vials (as the dihydrochloride), 50 mg, ml., Chloroquine Phosphate: Oral tablets 300 mg or 150 mg (of chloroquine)., U.S. Production: (1977) PROBABLY MORE THAN 4.5X10+5 G, PHOSPHATE, (1979) PROBABLY MORE THAN 4.5X10+5 G, U.S. Imports: (1977) 6X10+5 G-PRINCPL CUSTMS DISTS, (1979) 3X10+5 G-PRINCPL CUSTMS DISTS, General Manufacturing Information: Usually dispensed as the phosphate.

Applications

Documented applications: Uses: MEDICATION, Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant, Mesh Heading: Amebicides, antimalarials, antirheumatic Agents, Use (kg, approx.) in Germany (2009): >750, Consumption (g per capita, approx.) in Germany (2009): 0.00916, Excretion rate: 0.7, Calculated removal (%): 78.6, For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: H. Andersag et al., US 2233970 (1941 to Winthrop), Condensation of 4, 7-dichloroquinoline with 1-diethylamino-4-aminopentane: German patent 683692 (1939), Formulations, Preparations: Chloroquine phosphate, USP ... is available as tablets containing either 250 or 500 mg of diphosphate. Approximately 60% of diphosphate represents base., Chloroquine phosphate, Arechin, Avloclor, Imagon, Malaquin, Resochin, Tresochin., Chloroquine diphosphate, Nivaquine., Chloroquine Sulfate, Tablets (as the phosphate), 500 mg. Vials (as the dihydrochloride), 50 mg, ml., Chloroquine Phosphate: Oral tablets 300 mg or 150 mg (of chloroquine)., U.S. Production: (1977) PROBABLY MORE THAN 4.5X10+5 G, PHOSPHATE, (1979) PROBABLY MORE THAN 4.5X10+5 G, U.S. Imports: (1977) 6X10+5 G-PRINCPL CUSTMS DISTS, (1979) 3X10+5 G-PRINCPL CUSTMS DISTS, General Manufacturing Information: Usually dispensed as the phosphate..

Technical Profile

What this product is

chloroquine is a chemical compound with CAS registry number 54-05-7 and molecular formula C18H26ClN3 (molecular weight 319.9).

Identification

CAS number: 54-05-7

Its molecular formula C18H26ClN3 comprises 18 C, 26 H, 1 Cl, 3 N atoms.

Also known as: chloroquine · 氯喹

Frequently Asked Questions

What is the CAS number of chloroquine?

The CAS registry number of chloroquine is 54-05-7.

What is the molecular formula and molecular weight of chloroquine?

Molecular formula C18H26ClN3, molecular weight 319.9.

What other names is chloroquine known by?

It is also registered under: chloroquine, 氯喹.

What are the documented applications of chloroquine?

Recorded applications: Uses: MEDICATION, Antimalarial, antiamebic, antitheuratic, Lupus erthematus supressant, Mesh Heading: Amebicides, antimalarials, antirheumatic Agents, Use (kg, approx.) in Germany (2009): >750, Consumption (g per capita, approx.) in Germany (2009): 0.00916, Excretion rate: 0.7, Calculated removal (%): 78.6, For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: H. Andersag et al., US 2233970 (1941 to Winthrop), Condensation of 4, 7-dichloroquinoline with 1-diethylamino-4-aminopentane: German patent 683692 (1939), Formulations, Preparations: Chloroquine phosphate, USP ... is available as tablets containing either 250 or 500 mg of diphosphate. Approximately 60% of diphosphate represents base., Chloroquine phosphate, Arechin, Avloclor, Imagon, Malaquin, Resochin, Tresochin., Chloroquine diphosphate, Nivaquine., Chloroquine Sulfate, Tablets (as the phosphate), 500 mg. Vials (as the dihydrochloride), 50 mg, ml., Chloroquine Phosphate: Oral tablets 300 mg or 150 mg (of chloroquine)., U.S. Production: (1977) PROBABLY MORE THAN 4.5X10+5 G, PHOSPHATE, (1979) PROBABLY MORE THAN 4.5X10+5 G, U.S. Imports: (1977) 6X10+5 G-PRINCPL CUSTMS DISTS, (1979) 3X10+5 G-PRINCPL CUSTMS DISTS, General Manufacturing Information: Usually dispensed as the phosphate..

PubChem Public Data

Independent reference data for chloroquine (CAS 54-05-7), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	54-05-7
PubChem CID	2719
Molecular formula	C18H26ClN3
IUPAC name	4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
UNII (FDA)	886U3H6UFF

Computed descriptors

Molecular Weight	319.9
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Exact Mass	319.1815255
Monoisotopic Mass	319.1815255
Topological Polar Surface Area	28.2
Heavy Atom Count	22

Physicochemical values on record

Melting Point	87-89.5
Melting Point	87 °C
Melting Point	289 °C
Solubility	1.75e-02 g/L
LogP	4.63
LogP	log Kow = 4.63
LogP	4.3
LogP	4.61
Dissociation Constants	10.1
Dissociation Constants	pKa = 10.1

Documented uses on record

Synonyms and trade names

chloroquine; 54-05-7; Aralen; Chloraquine; Chlorochin; Artrichin; Chloroquina; Reumachlor; Chloroquinium; Capquin; Chlorquin; Arthrochin; Bipiquin; Clorochina; Gontochin; Klorokin

GHS hazard classification

Reported hazard statements	H302 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

What the public record says

chloroquine · CAS 54-05-7 · C18H26ClN3. UNII 886U3H6UFF. Melting Point: 87-89.5; Melting Point: 87 °C; Melting Point: 289 °C.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.