Cephalexin monohydrate (CAS 23325-78-2) — formula C16H17N3O4S, molecular weight 347.4; category organic chemicals.
| CAS Number | 23325-78-2 |
|---|---|
| Molecular Formula | C16H17N3O4S |
| Molecular Weight | 347.4 |
| Melting Point | 326.8 |
| Boiling Point | 727.4 |
| LogP | 0.65 |
| Applications | Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C. |
| Category | Organic Chemicals |
Documented applications: Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C..
Cephalexin monohydrate is a carbon-based organic compound with CAS registry number 23325-78-2 and molecular formula C16H17N3O4S (molecular weight 347.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 23325-78-2
Its molecular formula C16H17N3O4S comprises 16 C, 17 H, 3 N, 4 O, 1 S atoms.
Also known as: Cephalexin monohydrate · 头孢氨苄一水合物
Category: organic chemicals
The CAS registry number of Cephalexin monohydrate is 23325-78-2.
Molecular formula C16H17N3O4S, molecular weight 347.4.
It is also registered under: Cephalexin monohydrate, 头孢氨苄一水合物.
Recorded applications: Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C..
Category: Organic Chemicals.
Independent reference data for Cephalexin monohydrate (CAS 23325-78-2), compiled from public chemistry databases.
| CAS Registry Number | 23325-78-2 |
|---|---|
| PubChem CID | 27447 |
| Molecular formula | C16H17N3O4S |
| IUPAC name | (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| UNII (FDA) | 5SFF1W6677 |
| Molecular Weight | 347.4 |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 347.09397721 |
| Monoisotopic Mass | 347.09397721 |
| Topological Polar Surface Area | 138 |
| Heavy Atom Count | 24 |
| Boiling Point | 727.4 |
|---|---|
| Melting Point | 326.8 |
| Melting Point | 326.8 °C |
| Solubility | 10mg/mL |
| Solubility | 2.97e-01 g/L |
| LogP | 0.65 |
| LogP | logP = 0.65 |
| Dissociation Constants | 2.53 |
| Dissociation Constants | 7.14 |
| Dissociation Constants | PKA: 5.2, 7.3 |
cephalexin; Cefalexin; 15686-71-2; Cephacillin; Ceporexin; Mamalexin; Ceporex; Keflex; Carnosporin; Cefaleksin; Cephalexine; Cephalexinum; Ceporexine; Sinthecillin; Uphalexin; Alsporin
| Reported hazard statements | H317 (100%), H334 (100%) |
|---|
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
Cephalexin monohydrate · CAS 23325-78-2 · C16H17N3O4S. UNII 5SFF1W6677. Boiling Point: 727.4; Melting Point: 326.8; Melting Point: 326.8 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 头孢氨苄一水合物