Cabazitaxel

Description

Cabazitaxel · CAS 183133-96-2 · C45H57NO14. UNII 51F690397J. Melting Point: 170.

Identification

CAS Registry Number	183133-96-2
PubChem CID	9854073
Molecular formula	C45H57NO14
IUPAC name	[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
UNII (FDA)	51F690397J

Computed Descriptors

Molecular Weight	835.9
XLogP3	2.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	15
Exact Mass	835.37790549
Monoisotopic Mass	835.37790549
Topological Polar Surface Area	202
Heavy Atom Count	60
Formal Charge	0

Physical & Chemical Properties

Melting Point	170

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H302 (85.7%), H311 (42.9%), H315 (85.7%), H317 (14.3%), H318 (14.3%), H335 (14.3%), H341 (85.7%), H360 (57.1%)

Documented Uses

• Cabazitaxel is indicated, in combination with [prednisone], for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a [docetaxel]-containing treatment regimen. In Europe and Canada, it can also be used in combination with [prednisolone].
• Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel. Therapy with cabazitaxel has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury.
• Cabazitaxel is approved to be used with prednisone to treat:
• • Prostate cancer that has metastasized (spread to other parts of the body) in men whose cancer is castrate resistant (has not responded to treatments that lower testosterone levels) and who have already been treated with chemotherapy that included docetaxel.
• Cabazitaxel is also being studied in the treatment of other types of cancer.
• Avoid grapefruit products. Grapefruit inhibits the CYP3A4 metabolism of cabazitaxel, which may increase its serum concentration.

Synonyms

CABAZITAXEL; 183133-96-2; Jevtana; Taxoid XRP6258; Xrp6258; Cabazitaxelum; TXD 258; XRP-6258; Jevtana Kit; TXD258; Cabazitaxel Injection; XRP 6258; kabazitaxel; NSC-761432; TXD-258; 51F690397J

Frequently Asked Questions

What are the CAS number and molecular formula of Cabazitaxel?

CAS 183133-96-2; molecular formula C45H57NO14; molecular weight — g/mol.

What other names is Cabazitaxel known by?

CABAZITAXEL, 183133-96-2, Jevtana, Taxoid XRP6258, Xrp6258, Cabazitaxelum.

Is Cabazitaxel classified as hazardous?

Hazard statements reported: H302, H311, H315, H317, H318.

What are the key physical properties of Cabazitaxel?

Melting Point: 170.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.