金刚烷胺（CAS 768-94-5）：分子式 C10H17N、分子量 151.25。
| CAS号 | 768-94-5 |
|---|---|
| 分子式 | C10H17N |
| 分子量 | 151.25 |
| 熔点 | 180-192 |
| LogP | 2.44 |
| 应用领域 | Uses: MEDICATION (VET)、Used as a chemical intermediate for the synthesis of tromantadine.、Antiviral and treatment for Parkinson's disease、Analgesics、Non-Narcotic、Antiparkinson Agents、Antiviral Agents、Dopamine Agents、Prevent infection with various strains of influenza A virus.、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Excretion rate: 0.85、Calculated removal (%): 48.6、For the chemoprophylaxis、prophylaxis、and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Amantadine is brominated to 1-bromo compound、which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine、which is reacted with hydrogen chloride in suitable solvent to yield official salt.、amantadine hydrochloride、1-Bromoadamantane + acetonitrile (Ritter reaction)、Formulations、Preparations: Oral: Capsules、liquid-filled Tablets: 100 mg (available by nonpropriety name)、100 mg、Symmetrel、(Endo)、Solution: 50 mg、5 mL、Symmetrel Syrup ( with parabens)、(Endo).、Trade Names.Hydrochloride: Amazolon (Sawai)、Mantadine (Du Pont)、Mantadix (Du Pont、Rhône-Poulenc)、Symmetrel (Ciba-Geigy)、Virofral (Ferrosan). Sulfate: Contenton (SKD)、PK-Merz (Merz).、administered PO、intranasal、SC、IP、or aerosol routes.、General Manufacturing Information: Tricyclo[3.3.1.13、7]decan-1-amine: ACTIVE、Available commercially as the free base or the hydrochloride、sulfate、or fumarate salts. |
登记用途：Uses: MEDICATION (VET)、Used as a chemical intermediate for the synthesis of tromantadine.、Antiviral and treatment for Parkinson's disease、Analgesics、Non-Narcotic、Antiparkinson Agents、Antiviral Agents、Dopamine Agents、Prevent infection with various strains of influenza A virus.、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Excretion rate: 0.85、Calculated removal (%): 48.6、For the chemoprophylaxis、prophylaxis、and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Amantadine is brominated to 1-bromo compound、which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine、which is reacted with hydrogen chloride in suitable solvent to yield official salt.、amantadine hydrochloride、1-Bromoadamantane + acetonitrile (Ritter reaction)、Formulations、Preparations: Oral: Capsules、liquid-filled Tablets: 100 mg (available by nonpropriety name)、100 mg、Symmetrel、(Endo)、Solution: 50 mg、5 mL、Symmetrel Syrup ( with parabens)、(Endo).、Trade Names.Hydrochloride: Amazolon (Sawai)、Mantadine (Du Pont)、Mantadix (Du Pont、Rhône-Poulenc)、Symmetrel (Ciba-Geigy)、Virofral (Ferrosan). Sulfate: Contenton (SKD)、PK-Merz (Merz).、administered PO、intranasal、SC、IP、or aerosol routes.、General Manufacturing Information: Tricyclo[3.3.1.13、7]decan-1-amine: ACTIVE、Available commercially as the free base or the hydrochloride、sulfate、or fumarate salts.。
金刚烷胺 是一种化工化合物，登记 CAS 号为 768-94-5，分子式 C10H17N（分子量 151.25）。
登记 CAS 号：768-94-5
其分子式 C10H17N 由 10 个碳、17 个氢、1 个氮 组成。
别名/同义词：金刚烷胺 · amantadine
金刚烷胺 的 CAS 登记号为 768-94-5。
分子式 C10H17N，分子量 151.25。
别名/同义词：金刚烷胺、amantadine。
登记用途：Uses: MEDICATION (VET)、Used as a chemical intermediate for the synthesis of tromantadine.、Antiviral and treatment for Parkinson's disease、Analgesics、Non-Narcotic、Antiparkinson Agents、Antiviral Agents、Dopamine Agents、Prevent infection with various strains of influenza A virus.、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Excretion rate: 0.85、Calculated removal (%): 48.6、For the chemoprophylaxis、prophylaxis、and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Amantadine is brominated to 1-bromo compound、which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine、which is reacted with hydrogen chloride in suitable solvent to yield official salt.、amantadine hydrochloride、1-Bromoadamantane + acetonitrile (Ritter reaction)、Formulations、Preparations: Oral: Capsules、liquid-filled Tablets: 100 mg (available by nonpropriety name)、100 mg、Symmetrel、(Endo)、Solution: 50 mg、5 mL、Symmetrel Syrup ( with parabens)、(Endo).、Trade Names.Hydrochloride: Amazolon (Sawai)、Mantadine (Du Pont)、Mantadix (Du Pont、Rhône-Poulenc)、Symmetrel (Ciba-Geigy)、Virofral (Ferrosan). Sulfate: Contenton (SKD)、PK-Merz (Merz).、administered PO、intranasal、SC、IP、or aerosol routes.、General Manufacturing Information: Tricyclo[3.3.1.13、7]decan-1-amine: ACTIVE、Available commercially as the free base or the hydrochloride、sulfate、or fumarate salts.。
金刚烷胺（CAS 768-94-5）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 768-94-5 |
|---|---|
| PubChem CID | 2130 |
| Molecular formula | C10H17N |
| IUPAC name | adamantan-1-amine |
| UNII (FDA) | BF4C9Z1J53 |
| Molecular Weight | 151.25 |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 151.136099547 |
| Monoisotopic Mass | 151.136099547 |
| Topological Polar Surface Area | 26 |
| Heavy Atom Count | 11 |
| Melting Point | 180-192 |
|---|---|
| Melting Point | 180 °C |
| Solubility | 6290 |
| Solubility | 8.46e-02 g/L |
| LogP | 2.44 |
| LogP | log Kow = 2.44 |
| LogP | 2.3 |
| LogP | 2.54 |
| Dissociation Constants | 10.58 |
| Dissociation Constants | 10.68 |
amantadine; 1-Adamantanamine; 768-94-5; adamantan-1-amine; 1-Adamantylamine; 1-Aminoadamantane; Adamantanamine; Adamantylamine; Amantidine; Aminoadamantane; Adamantamine; Pk-merz; Amantadina; Amantadinum; Gocovri; Viregyt
| Reported hazard statements | H302 (100%), H314 (68.6%), H315 (31.4%), H318 (68.6%), H319 (31.4%), H335 (32.1%), H412 (68.6%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (68.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
amantadine · CAS 768-94-5 · C10H17N. UNII BF4C9Z1J53. Melting Point: 180-192; Melting Point: 180 °C; Solubility: 6290.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: amantadine