amantadine (CAS 768-94-5) — formula C10H17N, molecular weight 151.25.
| CAS Number | 768-94-5 |
|---|---|
| Molecular Formula | C10H17N |
| Molecular Weight | 151.25 |
| Melting Point | 180-192 |
| LogP | 2.44 |
| Applications | Uses: MEDICATION (VET), Used as a chemical intermediate for the synthesis of tromantadine., Antiviral and treatment for Parkinson's disease, Analgesics, Non-Narcotic, Antiparkinson Agents, Antiviral Agents, Dopamine Agents, Prevent infection with various strains of influenza A virus., Use (kg, approx.) in Germany (2009): >2500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Excretion rate: 0.85, Calculated removal (%): 48.6, For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Amantadine is brominated to 1-bromo compound, which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine, which is reacted with hydrogen chloride in suitable solvent to yield official salt., amantadine hydrochloride, 1-Bromoadamantane + acetonitrile (Ritter reaction), Formulations, Preparations: Oral: Capsules, liquid-filled Tablets: 100 mg (available by nonpropriety name), 100 mg, Symmetrel, (Endo), Solution: 50 mg, 5 mL, Symmetrel Syrup ( with parabens), (Endo)., Trade Names.Hydrochloride: Amazolon (Sawai), Mantadine (Du Pont), Mantadix (Du Pont, Rhône-Poulenc), Symmetrel (Ciba-Geigy), Virofral (Ferrosan). Sulfate: Contenton (SKD), PK-Merz (Merz)., administered PO, intranasal, SC, IP, or aerosol routes., General Manufacturing Information: Tricyclo[3.3.1.13, 7]decan-1-amine: ACTIVE, Available commercially as the free base or the hydrochloride, sulfate, or fumarate salts. |
Documented applications: Uses: MEDICATION (VET), Used as a chemical intermediate for the synthesis of tromantadine., Antiviral and treatment for Parkinson's disease, Analgesics, Non-Narcotic, Antiparkinson Agents, Antiviral Agents, Dopamine Agents, Prevent infection with various strains of influenza A virus., Use (kg, approx.) in Germany (2009): >2500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Excretion rate: 0.85, Calculated removal (%): 48.6, For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Amantadine is brominated to 1-bromo compound, which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine, which is reacted with hydrogen chloride in suitable solvent to yield official salt., amantadine hydrochloride, 1-Bromoadamantane + acetonitrile (Ritter reaction), Formulations, Preparations: Oral: Capsules, liquid-filled Tablets: 100 mg (available by nonpropriety name), 100 mg, Symmetrel, (Endo), Solution: 50 mg, 5 mL, Symmetrel Syrup ( with parabens), (Endo)., Trade Names.Hydrochloride: Amazolon (Sawai), Mantadine (Du Pont), Mantadix (Du Pont, Rhône-Poulenc), Symmetrel (Ciba-Geigy), Virofral (Ferrosan). Sulfate: Contenton (SKD), PK-Merz (Merz)., administered PO, intranasal, SC, IP, or aerosol routes., General Manufacturing Information: Tricyclo[3.3.1.13, 7]decan-1-amine: ACTIVE, Available commercially as the free base or the hydrochloride, sulfate, or fumarate salts..
amantadine is a chemical compound with CAS registry number 768-94-5 and molecular formula C10H17N (molecular weight 151.25).
CAS number: 768-94-5
Its molecular formula C10H17N comprises 10 C, 17 H, 1 N atoms.
Also known as: amantadine · 金刚烷胺
The CAS registry number of amantadine is 768-94-5.
Molecular formula C10H17N, molecular weight 151.25.
It is also registered under: amantadine, 金刚烷胺.
Recorded applications: Uses: MEDICATION (VET), Used as a chemical intermediate for the synthesis of tromantadine., Antiviral and treatment for Parkinson's disease, Analgesics, Non-Narcotic, Antiparkinson Agents, Antiviral Agents, Dopamine Agents, Prevent infection with various strains of influenza A virus., Use (kg, approx.) in Germany (2009): >2500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Excretion rate: 0.85, Calculated removal (%): 48.6, For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions (A308)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Amantadine is brominated to 1-bromo compound, which is then reacted with acetonitrile in presence of sulfuric acid to produce n-(1-adamantanyl)acetamide. Alkaline hydrolysis liberates amantadine, which is reacted with hydrogen chloride in suitable solvent to yield official salt., amantadine hydrochloride, 1-Bromoadamantane + acetonitrile (Ritter reaction), Formulations, Preparations: Oral: Capsules, liquid-filled Tablets: 100 mg (available by nonpropriety name), 100 mg, Symmetrel, (Endo), Solution: 50 mg, 5 mL, Symmetrel Syrup ( with parabens), (Endo)., Trade Names.Hydrochloride: Amazolon (Sawai), Mantadine (Du Pont), Mantadix (Du Pont, Rhône-Poulenc), Symmetrel (Ciba-Geigy), Virofral (Ferrosan). Sulfate: Contenton (SKD), PK-Merz (Merz)., administered PO, intranasal, SC, IP, or aerosol routes., General Manufacturing Information: Tricyclo[3.3.1.13, 7]decan-1-amine: ACTIVE, Available commercially as the free base or the hydrochloride, sulfate, or fumarate salts..
Independent reference data for amantadine (CAS 768-94-5), compiled from public chemistry databases.
| CAS Registry Number | 768-94-5 |
|---|---|
| PubChem CID | 2130 |
| Molecular formula | C10H17N |
| IUPAC name | adamantan-1-amine |
| UNII (FDA) | BF4C9Z1J53 |
| Molecular Weight | 151.25 |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 151.136099547 |
| Monoisotopic Mass | 151.136099547 |
| Topological Polar Surface Area | 26 |
| Heavy Atom Count | 11 |
| Melting Point | 180-192 |
|---|---|
| Melting Point | 180 °C |
| Solubility | 6290 |
| Solubility | 8.46e-02 g/L |
| LogP | 2.44 |
| LogP | log Kow = 2.44 |
| LogP | 2.3 |
| LogP | 2.54 |
| Dissociation Constants | 10.58 |
| Dissociation Constants | 10.68 |
amantadine; 1-Adamantanamine; 768-94-5; adamantan-1-amine; 1-Adamantylamine; 1-Aminoadamantane; Adamantanamine; Adamantylamine; Amantidine; Aminoadamantane; Adamantamine; Pk-merz; Amantadina; Amantadinum; Gocovri; Viregyt
| Reported hazard statements | H302 (100%), H314 (68.6%), H315 (31.4%), H318 (68.6%), H319 (31.4%), H335 (32.1%), H412 (68.6%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (68.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
amantadine · CAS 768-94-5 · C10H17N. UNII BF4C9Z1J53. Melting Point: 180-192; Melting Point: 180 °C; Solubility: 6290.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 金刚烷胺