6-mercaptopurine monohydrate

Description

6-mercaptopurine monohydrate · CAS 6112-76-1 · C5H4N4S. UNII PKK6MUZ20G. Melting Point: 313; Melting Point: 308 °C (decomposes); Melting Point: 313 °C.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Yellow crystalline powder
• Yellow prisms from water (+1 water)
• Dark yellow /Mercaptopurine hydrate/
• Nearly odorless
• Insoluble in water

GHS Hazard Classification

Documented Uses

• MEDICATION (VET): Rarely used in veterinary medicine. Veterinary uses of mercaptopurine have included adjunctive therapy of lymphosarcoma, acute leukemias, and severe rheumatoid arthritis. It may have potential benefit in treating other autoimmune conditions (eg, unresponsive ulcerative colitis) as well.
• Antimetabolites; Antimetabolites, Antineoplastic; Immunosuppressive Agents; Nucleic Acid Synthesis Inhibitors
• In the original and most simple synthesis, hypoxanthine is heated with an excess of phosphorous pentasulfide for several hours at 200 °C in, e.g., tetralin as the solvent.
• Preparation from 7-aminothiazolo[5,4-d]pyrimidine: G. H. Hitchings, G. B. Elion, United States of America patent 2721866 (1955 to Burroughs Wellcome).
• 6-Chloropurine + sodium thiocyanate (dehydrochlorination) thiocyanate hydrolysis
• For remission induction and maintenance therapy of acute lymphatic leukemia.

Synonyms

6-Mercaptopurine; mercaptopurine; 50-44-2; Mercapurin; 6-Thiopurine; 6-Thioxopurine; 9H-Purine-6-thiol; 6-Mercaptopurin; Puri-Nethol; 6-Thiohypoxanthine; 1,9-dihydro-6H-purine-6-thione; Mercaptopurin; 3,7-dihydropurine-6-thione; Hypoxanthine, thio-; 1,7-Dihydro-6H-purine-6-thione; Mercaptopurina

Frequently Asked Questions

What are the CAS number and molecular formula of 6-mercaptopurine monohydrate?

CAS 6112-76-1; molecular formula C5H4N4S; molecular weight — g/mol.

What other names is 6-mercaptopurine monohydrate known by?

6-Mercaptopurine, mercaptopurine, 50-44-2, Mercapurin, 6-Thiopurine, 6-Thioxopurine.

Is 6-mercaptopurine monohydrate classified as hazardous?

Hazard statements reported: H301, H302, H361, H340, H360.

What are the key physical properties of 6-mercaptopurine monohydrate?

Melting Point: 313; Melting Point: 308 °C (decomposes); Melting Point: 313 °C; Solubility: 68500.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.