5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)-（CAS 50918-36-0）：分子式 C14H14N8O4S3、分子量 454.5。
| CAS号 | 50918-36-0 |
|---|---|
| 分子式 | C14H14N8O4S3 |
| 分子量 | 454.5 |
| 熔点 | 198-200 °C (decomposes) |
| LogP | -0.58 |
| 应用领域 | Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins.、First-generation cephalosporins、Mesh Heading: anti-bacterial agents、MEDICATION、Use (kg、approx.) in Germany (2009): >10000、exact) in Germany (2009): 10132、Use (kg) in USA (2002): 4740、Consumption (g per capita、approx.) in Germany (2009): 0.122、exact) in Germany (2009): 0.124、Consumption (g per capita) in the USA (2002): 0.0168、Excretion rate: 1、Calculated removal (%): 22、Methods of Manufacturing: 7-AMINOCEPHALOSPORANIC ACID IS CONVERTED TO ITS SODIUM SALT & ACETYLATED WITH 1H-TETRAZOLE-1-ACETYL CHLORIDE & ACETOXY GROUP IS THEN DISPLACED BY REACTION WITH 5-METHYL-1、3、4-THIADIAZOLE-2-THIOL IN BUFFER SOLN. ...IS ISOLATED AS CEFAZOLIN (ACID) & CONVERTED TO SODIUM SALT WITH SODIUM BICARBONATE.、CEFAZOLIN SODIUM SALT、Formulations、Preparations: Trade Name ... Kefzol、Zolicef、From table、Parenteral: For injection: 500 mg (of cefazolin) Ancef、(GlaxoSmithKline)、Cefazolin Sodium for Injection、(American Pharmaceutical Partners)、(Sandoz)、1 g (of cefazolin) Ancef、10 g (of cefazolin) pharmacy bulk package Ancef、20 g (of cefazolin) pharmacy bulk package Cefazolin Sodium for Injection、(American Pharmaceutical Partners). For injection、.for IV infusion: 1 g (of cefazolin) Ancef Piggyback、(Abbott)、Cefazolin Sodium ADD-Vantage ( with 0.04% polysorbate 80)、Cefazolin Sodium for Injection Piggyback、(Sandoz).、Cefazolin sodium、General Manufacturing Information: Semi-synthetic antibiotic derived from 7-aminocephalosporanic acid、... South African patent 6804513 corresponds to US patent 3516997 (1969、1970 to Fujisawa). |
登记用途：Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins.、First-generation cephalosporins、Mesh Heading: anti-bacterial agents、MEDICATION、Use (kg、approx.) in Germany (2009): >10000、exact) in Germany (2009): 10132、Use (kg) in USA (2002): 4740、Consumption (g per capita、approx.) in Germany (2009): 0.122、exact) in Germany (2009): 0.124、Consumption (g per capita) in the USA (2002): 0.0168、Excretion rate: 1、Calculated removal (%): 22、Methods of Manufacturing: 7-AMINOCEPHALOSPORANIC ACID IS CONVERTED TO ITS SODIUM SALT & ACETYLATED WITH 1H-TETRAZOLE-1-ACETYL CHLORIDE & ACETOXY GROUP IS THEN DISPLACED BY REACTION WITH 5-METHYL-1、3、4-THIADIAZOLE-2-THIOL IN BUFFER SOLN. ...IS ISOLATED AS CEFAZOLIN (ACID) & CONVERTED TO SODIUM SALT WITH SODIUM BICARBONATE.、CEFAZOLIN SODIUM SALT、Formulations、Preparations: Trade Name ... Kefzol、Zolicef、From table、Parenteral: For injection: 500 mg (of cefazolin) Ancef、(GlaxoSmithKline)、Cefazolin Sodium for Injection、(American Pharmaceutical Partners)、(Sandoz)、1 g (of cefazolin) Ancef、10 g (of cefazolin) pharmacy bulk package Ancef、20 g (of cefazolin) pharmacy bulk package Cefazolin Sodium for Injection、(American Pharmaceutical Partners). For injection、.for IV infusion: 1 g (of cefazolin) Ancef Piggyback、(Abbott)、Cefazolin Sodium ADD-Vantage ( with 0.04% polysorbate 80)、Cefazolin Sodium for Injection Piggyback、(Sandoz).、Cefazolin sodium、General Manufacturing Information: Semi-synthetic antibiotic derived from 7-aminocephalosporanic acid、... South African patent 6804513 corresponds to US patent 3516997 (1969、1970 to Fujisawa).。
5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)- 是一种化工化合物，登记 CAS 号为 50918-36-0，分子式 C14H14N8O4S3（分子量 454.5）。
登记 CAS 号：50918-36-0
其分子式 C14H14N8O4S3 由 14 个碳、14 个氢、8 个氮、4 个氧、3 个硫 组成。
别名/同义词：5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)- · 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, trans-(+-)-
5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)- 的 CAS 登记号为 50918-36-0。
分子式 C14H14N8O4S3，分子量 454.5。
别名/同义词：5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)-、5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, trans-(+-)-。
登记用途：Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins.、First-generation cephalosporins、Mesh Heading: anti-bacterial agents、MEDICATION、Use (kg、approx.) in Germany (2009): >10000、exact) in Germany (2009): 10132、Use (kg) in USA (2002): 4740、Consumption (g per capita、approx.) in Germany (2009): 0.122、exact) in Germany (2009): 0.124、Consumption (g per capita) in the USA (2002): 0.0168、Excretion rate: 1、Calculated removal (%): 22、Methods of Manufacturing: 7-AMINOCEPHALOSPORANIC ACID IS CONVERTED TO ITS SODIUM SALT & ACETYLATED WITH 1H-TETRAZOLE-1-ACETYL CHLORIDE & ACETOXY GROUP IS THEN DISPLACED BY REACTION WITH 5-METHYL-1、3、4-THIADIAZOLE-2-THIOL IN BUFFER SOLN. ...IS ISOLATED AS CEFAZOLIN (ACID) & CONVERTED TO SODIUM SALT WITH SODIUM BICARBONATE.、CEFAZOLIN SODIUM SALT、Formulations、Preparations: Trade Name ... Kefzol、Zolicef、From table、Parenteral: For injection: 500 mg (of cefazolin) Ancef、(GlaxoSmithKline)、Cefazolin Sodium for Injection、(American Pharmaceutical Partners)、(Sandoz)、1 g (of cefazolin) Ancef、10 g (of cefazolin) pharmacy bulk package Ancef、20 g (of cefazolin) pharmacy bulk package Cefazolin Sodium for Injection、(American Pharmaceutical Partners). For injection、.for IV infusion: 1 g (of cefazolin) Ancef Piggyback、(Abbott)、Cefazolin Sodium ADD-Vantage ( with 0.04% polysorbate 80)、Cefazolin Sodium for Injection Piggyback、(Sandoz).、Cefazolin sodium、General Manufacturing Information: Semi-synthetic antibiotic derived from 7-aminocephalosporanic acid、... South African patent 6804513 corresponds to US patent 3516997 (1969、1970 to Fujisawa).。
5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)-（CAS 50918-36-0）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 50918-36-0 |
|---|---|
| PubChem CID | 33255 |
| 分子式 | C14H14N8O4S3 |
| IUPAC 名称 | (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| UNII（FDA） | IHS69L0Y4T |
| Molecular Weight | 454.5 |
|---|---|
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 7 |
| Exact Mass | 454.03001448 |
| Monoisotopic Mass | 454.03001448 |
| Topological Polar Surface Area | 235 |
| Heavy Atom Count | 29 |
| Melting Point | 198-200 °C (decomposes) |
|---|---|
| Solubility | 4.87e-01 g/L |
| LogP | -0.58 |
| LogP | log Kow = -0.58 |
| LogP | -0.24 |
cefazolin; 25953-19-9; Cephazolin; Cefazoline; Cephamezine; Cefamezin; Cephazoline; Cephazolidin; Cefazolina; Cefazolinum; Elzogram; DTXSID2022753; IHS69L0Y4T; J01DB04; CHEBI:474053; DTXCID302753
| 已通报的危害声明 | H317 (100%), H334 (100%) |
|---|
5-Thia-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，3-[[(5-甲基-1,3,4-噻二唑-2-基)硫基]甲基]-8-氧代-7-[(1H-四唑-1-基乙酰基)氨基]-，反式-(+-)- · CAS 50918-36-0 · C14H14N8O4S3. UNII IHS69L0Y4T. Melting Point: 198-200 °C (decomposes); Solubility: 4.87e-01 g/L; LogP: -0.58.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。