5-formyltetrahydrofolic acid (CAS 58-05-9) — formula C20H23N7O7, molecular weight 473.4; category organic chemicals.
5-formyltetrahydrofolic acid (CAS 58-05-9) is a chemical raw material in the organic chemicals category. Its molecular formula C20H23N7O7 comprises 20 C, 23 H, 7 N, 7 O atoms. Its molecular weight is about 473.4. Reported physicochemical data: melting point around >260, LogP about -1.2. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 58-05-9 |
|---|---|
| Molecular Formula | C20H23N7O7 |
| Molecular Weight | 473.4 |
| Melting Point | >260 |
| LogP | -1.2 |
| Applications | Biochemical research, MEDICATION, For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate, Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid, (2) produced microbially |
| Category | Organic Chemicals |
Documented applications: Biochemical research, MEDICATION, For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate, Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid, (2) produced microbially.
5-formyltetrahydrofolic acid is a carbon-based organic compound with CAS registry number 58-05-9 and molecular formula C20H23N7O7 (molecular weight 473.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 58-05-9
Its molecular formula C20H23N7O7 comprises 20 C, 23 H, 7 N, 7 O atoms.
Also known as: 5-formyltetrahydrofolic acid · 5-甲酰四氢叶酸
Category: organic chemicals
The CAS registry number of 5-formyltetrahydrofolic acid is 58-05-9.
Molecular formula C20H23N7O7, molecular weight 473.4.
It is also registered under: 5-formyltetrahydrofolic acid, 5-甲酰四氢叶酸.
Recorded applications: Biochemical research, MEDICATION, For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate, Methods of Manufacturing: (1) Prepared by catalytic reduction of folic acid, (2) produced microbially.
Category: Organic Chemicals.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for 5-formyltetrahydrofolic acid (CAS 58-05-9), compiled from public chemistry databases.
| CAS Registry Number | 58-05-9 |
|---|---|
| PubChem CID | 135403648 |
| Molecular formula | C20H23N7O7 |
| IUPAC name | (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| UNII (FDA) | Q573I9DVLP |
| Molecular Weight | 473.4 |
|---|---|
| XLogP3 | -1.2 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Exact Mass | 473.16589610 |
| Monoisotopic Mass | 473.16589610 |
| Topological Polar Surface Area | 216 |
| Heavy Atom Count | 34 |
| Melting Point | >260 |
|---|---|
| Melting Point | 245 °C (decomp) |
| Collision Cross Section | 201.7 Ų [M-H]- |
| Collision Cross Section | 197.5 Ų [M+H]+ |
folinic acid; leucovorin; 58-05-9; 5-Formyltetrahydrofolic acid; folinate; Folinic acid-SF; 5-formyltetrahydrofolate; Acide folinique; 5-Formyl-5,6,7,8-tetrahydrofolic acid; N5-Formyltetrahydrofolic acid; N5-Formyl-5,6,7,8-tetrahydrofolic acid; Q573I9DVLP; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid; DTXSID0048216; CHEBI:15640; (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
5-formyltetrahydrofolic acid · CAS 58-05-9 · C20H23N7O7. UNII Q573I9DVLP. Melting Point: >260; Melting Point: 245 °C (decomp); Collision Cross Section: 201.7 Ų [M-H]-.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 5-甲酰四氢叶酸