5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺（CAS 738-70-5）：分子式 C14H18N4O3、分子量 290.32。
| CAS号 | 738-70-5 |
|---|---|
| 分子式 | C14H18N4O3 |
| 分子量 | 290.32 |
| 熔点 | 390 to 397 °F (NTP, 1992) |
| LogP | 0.91 |
| 应用领域 | Uses: Veterinary antimicrobial agent、Has a broad spectrum of antimicrobial activity and extends the spectrum of sulfamethoxazole to include many urinary and systemic pathogens untreatable by this sulfa drug alone.、MEDICATION (VET)、MEDICATION、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): ?7500、exact) in Germany (2009): 7475、Use (kg) in USA (2002): 463、Use (kg) in France (2004): 3346、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.092、exact) in Germany (2009): 0.091、Consumption (g per capita) in the USA (2002): 0.0016、Consumption (g per capita) in France (2004): 0.055、Excretion rate: 0.6、Calculated removal (%): 8.8、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Prepn from guanidine and beta-ethoxy-3、4、5-trimethoxybenzylbenzalnitrile、Trimethoprim、is a、drug that、is、made from vanillin.、Formulations、Preparations: Preparations: Tablets、100 and 200 mg.、Component of Bactrin and Septra、General Manufacturing Information: See sulfamethoxazole、sulfadiazine、sulfametrole、sulfamoxole、and sulfalene for list of trade names of mixtures with trimethoprim.、Authorized or allowed for use in aquaculture in certain European countries.、Solid phase reactions between trimethoprim & sulfamethoxazole were investigated by IR spectrometry & differential scanning calorimetry in 4 tablet formulations. Heating & humidity were found to enhance the conditions for reactions、with the most likely manufacturing step causing reactions being wet granulation. Mixing、grinding & compression of powders caused no interactions. |
登记用途：Uses: Veterinary antimicrobial agent、Has a broad spectrum of antimicrobial activity and extends the spectrum of sulfamethoxazole to include many urinary and systemic pathogens untreatable by this sulfa drug alone.、MEDICATION (VET)、MEDICATION、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): ?7500、exact) in Germany (2009): 7475、Use (kg) in USA (2002): 463、Use (kg) in France (2004): 3346、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.092、exact) in Germany (2009): 0.091、Consumption (g per capita) in the USA (2002): 0.0016、Consumption (g per capita) in France (2004): 0.055、Excretion rate: 0.6、Calculated removal (%): 8.8、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Prepn from guanidine and beta-ethoxy-3、4、5-trimethoxybenzylbenzalnitrile、Trimethoprim、is a、drug that、is、made from vanillin.、Formulations、Preparations: Preparations: Tablets、100 and 200 mg.、Component of Bactrin and Septra、General Manufacturing Information: See sulfamethoxazole、sulfadiazine、sulfametrole、sulfamoxole、and sulfalene for list of trade names of mixtures with trimethoprim.、Authorized or allowed for use in aquaculture in certain European countries.、Solid phase reactions between trimethoprim & sulfamethoxazole were investigated by IR spectrometry & differential scanning calorimetry in 4 tablet formulations. Heating & humidity were found to enhance the conditions for reactions、with the most likely manufacturing step causing reactions being wet granulation. Mixing、grinding & compression of powders caused no interactions.。
5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺 是一种化工化合物，登记 CAS 号为 738-70-5，分子式 C14H18N4O3（分子量 290.32）。
登记 CAS 号：738-70-5
其分子式 C14H18N4O3 由 14 个碳、18 个氢、4 个氮、3 个氧 组成。
别名/同义词：5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺 · 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺 的 CAS 登记号为 738-70-5。
分子式 C14H18N4O3，分子量 290.32。
别名/同义词：5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺、5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine。
登记用途：Uses: Veterinary antimicrobial agent、Has a broad spectrum of antimicrobial activity and extends the spectrum of sulfamethoxazole to include many urinary and systemic pathogens untreatable by this sulfa drug alone.、MEDICATION (VET)、MEDICATION、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): ?7500、exact) in Germany (2009): 7475、Use (kg) in USA (2002): 463、Use (kg) in France (2004): 3346、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.092、exact) in Germany (2009): 0.091、Consumption (g per capita) in the USA (2002): 0.0016、Consumption (g per capita) in France (2004): 0.055、Excretion rate: 0.6、Calculated removal (%): 8.8、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Prepn from guanidine and beta-ethoxy-3、4、5-trimethoxybenzylbenzalnitrile、Trimethoprim、is a、drug that、is、made from vanillin.、Formulations、Preparations: Preparations: Tablets、100 and 200 mg.、Component of Bactrin and Septra、General Manufacturing Information: See sulfamethoxazole、sulfadiazine、sulfametrole、sulfamoxole、and sulfalene for list of trade names of mixtures with trimethoprim.、Authorized or allowed for use in aquaculture in certain European countries.、Solid phase reactions between trimethoprim & sulfamethoxazole were investigated by IR spectrometry & differential scanning calorimetry in 4 tablet formulations. Heating & humidity were found to enhance the conditions for reactions、with the most likely manufacturing step causing reactions being wet granulation. Mixing、grinding & compression of powders caused no interactions.。
5-((3,4,5-三甲氧基苯基)甲基)-2,4-嘧啶二胺（CAS 738-70-5）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 738-70-5 |
|---|---|
| PubChem CID | 5578 |
| Molecular formula | C14H18N4O3 |
| IUPAC name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| UNII (FDA) | AN164J8Y0X |
| Molecular Weight | 290.32 |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 290.13789045 |
| Monoisotopic Mass | 290.13789045 |
| Topological Polar Surface Area | 106 |
| Heavy Atom Count | 21 |
| Melting Point | 390 to 397 °F (NTP, 1992) |
|---|---|
| Melting Point | 199-203 °C |
| Melting Point | 199 - 203 °C |
| Solubility | 400 |
| Solubility | In water, 400 mg/l @ 25 °C |
| Solubility | 6.15e-01 g/L |
| LogP | 0.91 |
| LogP | log Kow = 0.91 |
| LogP | 0.6 |
| LogP | 0.92 |
trimethoprim; 738-70-5; Proloprim; Trimpex; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; Trimetoprim; Monotrim; Trimopan; Wellcoprim; Syraprim; Monoprim; Uretrim; Trimethoprime; Trimethoprimum; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine; Trimetoprima
| GHS notification summary | 7.9% (11 / 140) |
|---|
| GHS notification summary | 7.9% (11 / 140) |
|---|---|
| Reported hazard statements | H302 (85%), H361 (30.7%), H372 (26.4%), H411 (26.4%), H301, H360, H362, H373 |
This chemical does not meet GHS hazard criteria for 7.9% (11 of 140) of reports.
H302 (85%): Harmful if swallowed [Warning Acute toxicity, oral]
5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine · CAS 738-70-5 · C14H18N4O3. UNII AN164J8Y0X. Melting Point: 390 to 397 °F (NTP, 1992); Melting Point: 199-203 °C; Melting Point: 199 - 203 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine