2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (CAS 4065-45-6) — formula C14H12O6S, molecular weight 308.31; category organic chemicals.
| CAS Number | 4065-45-6 |
|---|---|
| Molecular Formula | C14H12O6S |
| Molecular Weight | 308.31 |
| Melting Point | 145 |
| LogP | 2.2 |
| Applications | Uses: CIR ingredient: Benzophenone-4, Used as ultraviolet absorber for leather and textiles, and ultraviolet screen for humans, Also used in cosmetics and shampoos, [Merck Index], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], Ultraviolet absorber for leather and textile fibers, in cosmetics and shampoos., Used as an ultraviolet absorber in US cosmetics at concentrations of 5-10%, Benzophenones-2, -3, -4, -6, -8, and -9 are used in suntan lotions and hair sprays because they protect the skin and hair from the harmful effects of the sun. These ingredients also photostabilize cosmetic dyes, creams, and lotion's., Use Classification: Cosmetics -> Uv absorber, Uv filter, Household Products: Cosmetics product ingredient: Benzophenone-4, Product count: 5, Information on 125 consumer products that contain Benzophenone-4 in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Inside the Home, • Personal Care, Methods of Manufacturing: Benzophenone-4 is prepared via sulfonation of Benzophenone-3. The product is purified by precipitation from aqueous HCl, isolated by centrifugation, washed with acidic water, and dried., Preparation: A.J. Cofrancesco, United Kingdom 1136525 (1968 to GAF), Formulations, Preparations: The maximum recommended levels of lead and arsenic impurities in Benzophenone-4 are, 13 ppm and 1 ppm respectively, ., U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7083], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. Aggregated National Production Volume: < 500, 000 pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. National Production Volume: Withheld., General Manufacturing Information: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-: ACTIVE, The FDA Panel on Review of Topical Analgesics has proposed that Benzophenones-3, and -8 are safe and effective as active ingredients in sunscreens for over-the-counter (OTC) use at the following concentrations: Benzophenone-3, 2%-6%, Benzophenone-4, 5%-10%, and Benzophenone-8, 3%. The Panel proposed these concentration limits on a combined safety and efficacy basis (a concentration limit may reflect maximum efficacy and not necessarily an indication of toxicity at a higher concentration)., Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations, a listing of commercially available sunscreens is not included in this monograph., Sunscreens |
| Category | Organic Chemicals |
Documented applications: Uses: CIR ingredient: Benzophenone-4, Used as ultraviolet absorber for leather and textiles, and ultraviolet screen for humans, Also used in cosmetics and shampoos, [Merck Index], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], Ultraviolet absorber for leather and textile fibers, in cosmetics and shampoos., Used as an ultraviolet absorber in US cosmetics at concentrations of 5-10%, Benzophenones-2, -3, -4, -6, -8, and -9 are used in suntan lotions and hair sprays because they protect the skin and hair from the harmful effects of the sun. These ingredients also photostabilize cosmetic dyes, creams, and lotion's., Use Classification: Cosmetics -> Uv absorber, Uv filter, Household Products: Cosmetics product ingredient: Benzophenone-4, Product count: 5, Information on 125 consumer products that contain Benzophenone-4 in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Inside the Home, • Personal Care, Methods of Manufacturing: Benzophenone-4 is prepared via sulfonation of Benzophenone-3. The product is purified by precipitation from aqueous HCl, isolated by centrifugation, washed with acidic water, and dried., Preparation: A.J. Cofrancesco, United Kingdom 1136525 (1968 to GAF), Formulations, Preparations: The maximum recommended levels of lead and arsenic impurities in Benzophenone-4 are, 13 ppm and 1 ppm respectively, ., U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7083], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. Aggregated National Production Volume: < 500, 000 pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. National Production Volume: Withheld., General Manufacturing Information: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-: ACTIVE, The FDA Panel on Review of Topical Analgesics has proposed that Benzophenones-3, and -8 are safe and effective as active ingredients in sunscreens for over-the-counter (OTC) use at the following concentrations: Benzophenone-3, 2%-6%, Benzophenone-4, 5%-10%, and Benzophenone-8, 3%. The Panel proposed these concentration limits on a combined safety and efficacy basis (a concentration limit may reflect maximum efficacy and not necessarily an indication of toxicity at a higher concentration)., Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations, a listing of commercially available sunscreens is not included in this monograph., Sunscreens.
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a carbon-based organic compound with CAS registry number 4065-45-6 and molecular formula C14H12O6S (molecular weight 308.31), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 4065-45-6
Its molecular formula C14H12O6S comprises 14 C, 12 H, 6 O, 1 S atoms.
Also known as: 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid · 2-羟基-4-甲氧基二苯甲酮-5-磺酸
Category: organic chemicals
The CAS registry number of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is 4065-45-6.
Molecular formula C14H12O6S, molecular weight 308.31.
It is also registered under: 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-羟基-4-甲氧基二苯甲酮-5-磺酸.
Recorded applications: Uses: CIR ingredient: Benzophenone-4, Used as ultraviolet absorber for leather and textiles, and ultraviolet screen for humans, Also used in cosmetics and shampoos, [Merck Index], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], Ultraviolet absorber for leather and textile fibers, in cosmetics and shampoos., Used as an ultraviolet absorber in US cosmetics at concentrations of 5-10%, Benzophenones-2, -3, -4, -6, -8, and -9 are used in suntan lotions and hair sprays because they protect the skin and hair from the harmful effects of the sun. These ingredients also photostabilize cosmetic dyes, creams, and lotion's., Use Classification: Cosmetics -> Uv absorber, Uv filter, Household Products: Cosmetics product ingredient: Benzophenone-4, Product count: 5, Information on 125 consumer products that contain Benzophenone-4 in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Inside the Home, • Personal Care, Methods of Manufacturing: Benzophenone-4 is prepared via sulfonation of Benzophenone-3. The product is purified by precipitation from aqueous HCl, isolated by centrifugation, washed with acidic water, and dried., Preparation: A.J. Cofrancesco, United Kingdom 1136525 (1968 to GAF), Formulations, Preparations: The maximum recommended levels of lead and arsenic impurities in Benzophenone-4 are, 13 ppm and 1 ppm respectively, ., U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7083], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. Aggregated National Production Volume: < 500, 000 pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-. National Production Volume: Withheld., General Manufacturing Information: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-: ACTIVE, The FDA Panel on Review of Topical Analgesics has proposed that Benzophenones-3, and -8 are safe and effective as active ingredients in sunscreens for over-the-counter (OTC) use at the following concentrations: Benzophenone-3, 2%-6%, Benzophenone-4, 5%-10%, and Benzophenone-8, 3%. The Panel proposed these concentration limits on a combined safety and efficacy basis (a concentration limit may reflect maximum efficacy and not necessarily an indication of toxicity at a higher concentration)., Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations, a listing of commercially available sunscreens is not included in this monograph., Sunscreens.
Category: Organic Chemicals.
Independent reference data for 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (CAS 4065-45-6), compiled from public chemistry databases.
| CAS 号 | 4065-45-6 |
|---|---|
| PubChem CID | 19988 |
| 分子式 | C14H12O6S |
| IUPAC 名称 | 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid |
| UNII（FDA） | 1W6L629B4K |
| Molecular Weight | 308.31 |
|---|---|
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 308.03545927 |
| Monoisotopic Mass | 308.03545927 |
| Topological Polar Surface Area | 109 |
| Heavy Atom Count | 21 |
| Melting Point | 145 |
|---|---|
| Melting Point | 145 °C |
| Solubility | 10 |
| Solubility | In water, 2.5X10+5 mg/L at 25 °C |
| Collision Cross Section | 167.11 Ų [M+H]+ |
| Collision Cross Section | 184.79 Ų [M+Na]+ |
| Collision Cross Section | 168.59 Ų [M-H]- |
Sulisobenzone; 4065-45-6; 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid; Benzophenone-4; 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid; Sungard; Uval; Benzophenone 4; Seesorb 101S; Syntase 230; Spectra-Sorb UV 284; Sulisobenzona; Uvinul MS 40; Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-; Sulfisobenzone; Sulisobenzonum
| 法规与食品接触 | CIR / INCI: Cosmetic ingredients (Benzophenone-4) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Uv filter; Uv absorber |
|---|---|
| GHS 通报统计 | 10.4% (54 / 521) |
| GHS 通报统计 | 10.4% (54 / 521) |
|---|---|
| 已通报的危害声明 | H315 (84.3%), H317 (53.2%), H318 (28%), H319 (61.4%), H335 (18.2%) |
2-羟基-4-甲氧基-5-磺酸二苯甲酮; 紫外线吸收剂 UVBP-4; 紫外线吸收剂 UV 284 · CAS 4065-45-6 · C14H12O6S. UNII 1W6L629B4K. Melting Point: 145; Melting Point: 145 °C; Solubility: 10.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 2-羟基-4-甲氧基二苯甲酮-5-磺酸