(1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol (CAS 10334-13-1) — formula C10H18O, molecular weight 154.25; category organic chemicals.
| CAS Number | 10334-13-1 |
|---|---|
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 |
| Melting Point | 216 °C |
| LogP | log Kow = 3.24 |
| Applications | Uses: Used as a synthetic flavor, In over-the-counter preparations containing <11% camphor, it has been used as a moth repellent, cold sore topical medication, muscle liniment, and steam-inhaled cough suppressant, [HSDB] Used in perfumes, [Hawley], For isoborneol (USEPA, OPP Pesticide Code: 047089) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Reported uses (ppm):, Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#4225], Perfumery, chemical esters., The repellence of the plant-derived bicyclic monoterpenoid isoborneol on subterranean termites was assessed in short-term laboratory bioassays. Depending on concentration, application of isoborneol to different soil types was efficient in creating repellent soil barriers, which were not penetrated by workers of Reticulitermes santonensis De Feytaud or R. flavipes Kollar within 2 wk after adding the substance to the substrate. Isoborneol-treated barriers did not affect termite survival. The bioavailability of the active ingredient decreased with increasing clay content of the soil. Evaporation of isoborneol from treated soil increased with increasing particle size of the substrate and could be reduced by covering the soil surface., MEDICATION, Use Classification: Fragrance Ingredients, Flavoring Agents -> JECFA Flavorings Index, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Industry Uses: Other, Fragrance, Consumer Uses: Fragrance, Household Products: Information on 6 consumer products that contain Isoborneol in the following categories is provided:, • Commercial, Institutional, • Inside the Home, Methods of Manufacturing: By hydrolysis of isobornyl acetate, or by catalytic reduction of camphor (both d- and l-isomers), the optically inactive compound can be prepared by treating camphene with 1:1 mixture of sulfuric acid and glacial acetic acid and then hydrolyzing the isobornyl acetate., U.S. Production: 2023: 250, 000 - <400, 000 lb, 2022: 250, 2021: 250, 2020: 50, 000 - <250, Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Isoborneol:, Table: National Aggregate Production Volume (pounds) [Table#4224], General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing, Not Known or Reasonably Ascertainable, Plastics Material and Resin Manufacturing, Soap, Cleaning Compound, and Toilet Preparation Manufacturing, Bicyclo[2.2.1]heptan-2-ol, 1, 7, 7-trimethyl-, (1R, 2R, 4R)-rel-: ACTIVE, Borneol is an endo isomer, the corresponding exo isomer is isoborneol, Natural occurrence: Ashanti pepper (Piper guineense Schum and Thom) Ginger (Zingiber species) Grape brandy Camomile Honey Cheese, various types Mastic (Pistacia lentiscus) Cinnamomum species Ocimum species Curcuma species Papaya (Carica papaya L.) Eucalyptus oil (Eucalyptus globulus Labill) Raspberry, blackberry and boysenberry Rooibos tea (Aspalathus linearis) Salvia species Rosemary (Rosmarinus officinalis L.) Thyme (Thymus species) |
| Category | Organic Chemicals |
Documented applications: Uses: Used as a synthetic flavor, In over-the-counter preparations containing <11% camphor, it has been used as a moth repellent, cold sore topical medication, muscle liniment, and steam-inhaled cough suppressant, [HSDB] Used in perfumes, [Hawley], For isoborneol (USEPA, OPP Pesticide Code: 047089) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Reported uses (ppm):, Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#4225], Perfumery, chemical esters., The repellence of the plant-derived bicyclic monoterpenoid isoborneol on subterranean termites was assessed in short-term laboratory bioassays. Depending on concentration, application of isoborneol to different soil types was efficient in creating repellent soil barriers, which were not penetrated by workers of Reticulitermes santonensis De Feytaud or R. flavipes Kollar within 2 wk after adding the substance to the substrate. Isoborneol-treated barriers did not affect termite survival. The bioavailability of the active ingredient decreased with increasing clay content of the soil. Evaporation of isoborneol from treated soil increased with increasing particle size of the substrate and could be reduced by covering the soil surface., MEDICATION, Use Classification: Fragrance Ingredients, Flavoring Agents -> JECFA Flavorings Index, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Industry Uses: Other, Fragrance, Consumer Uses: Fragrance, Household Products: Information on 6 consumer products that contain Isoborneol in the following categories is provided:, • Commercial, Institutional, • Inside the Home, Methods of Manufacturing: By hydrolysis of isobornyl acetate, or by catalytic reduction of camphor (both d- and l-isomers), the optically inactive compound can be prepared by treating camphene with 1:1 mixture of sulfuric acid and glacial acetic acid and then hydrolyzing the isobornyl acetate., U.S. Production: 2023: 250, 000 - <400, 000 lb, 2022: 250, 2021: 250, 2020: 50, 000 - <250, Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Isoborneol:, Table: National Aggregate Production Volume (pounds) [Table#4224], General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing, Not Known or Reasonably Ascertainable, Plastics Material and Resin Manufacturing, Soap, Cleaning Compound, and Toilet Preparation Manufacturing, Bicyclo[2.2.1]heptan-2-ol, 1, 7, 7-trimethyl-, (1R, 2R, 4R)-rel-: ACTIVE, Borneol is an endo isomer, the corresponding exo isomer is isoborneol, Natural occurrence: Ashanti pepper (Piper guineense Schum and Thom) Ginger (Zingiber species) Grape brandy Camomile Honey Cheese, various types Mastic (Pistacia lentiscus) Cinnamomum species Ocimum species Curcuma species Papaya (Carica papaya L.) Eucalyptus oil (Eucalyptus globulus Labill) Raspberry, blackberry and boysenberry Rooibos tea (Aspalathus linearis) Salvia species Rosemary (Rosmarinus officinalis L.) Thyme (Thymus species).
(1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol is a carbon-based organic compound with CAS registry number 10334-13-1 and molecular formula C10H18O (molecular weight 154.25), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 10334-13-1
Its molecular formula C10H18O comprises 10 C, 18 H, 1 O atoms.
Also known as: (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol · (1R,4R)-1,7,7-三甲基双环[2.2.1]庚-2α-醇
Category: organic chemicals
The CAS registry number of (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol is 10334-13-1.
Molecular formula C10H18O, molecular weight 154.25.
It is also registered under: (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol, (1R,4R)-1,7,7-三甲基双环[2.2.1]庚-2α-醇.
Recorded applications: Uses: Used as a synthetic flavor, In over-the-counter preparations containing <11% camphor, it has been used as a moth repellent, cold sore topical medication, muscle liniment, and steam-inhaled cough suppressant, [HSDB] Used in perfumes, [Hawley], For isoborneol (USEPA, OPP Pesticide Code: 047089) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Reported uses (ppm):, Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#4225], Perfumery, chemical esters., The repellence of the plant-derived bicyclic monoterpenoid isoborneol on subterranean termites was assessed in short-term laboratory bioassays. Depending on concentration, application of isoborneol to different soil types was efficient in creating repellent soil barriers, which were not penetrated by workers of Reticulitermes santonensis De Feytaud or R. flavipes Kollar within 2 wk after adding the substance to the substrate. Isoborneol-treated barriers did not affect termite survival. The bioavailability of the active ingredient decreased with increasing clay content of the soil. Evaporation of isoborneol from treated soil increased with increasing particle size of the substrate and could be reduced by covering the soil surface., MEDICATION, Use Classification: Fragrance Ingredients, Flavoring Agents -> JECFA Flavorings Index, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Industry Uses: Other, Fragrance, Consumer Uses: Fragrance, Household Products: Information on 6 consumer products that contain Isoborneol in the following categories is provided:, • Commercial, Institutional, • Inside the Home, Methods of Manufacturing: By hydrolysis of isobornyl acetate, or by catalytic reduction of camphor (both d- and l-isomers), the optically inactive compound can be prepared by treating camphene with 1:1 mixture of sulfuric acid and glacial acetic acid and then hydrolyzing the isobornyl acetate., U.S. Production: 2023: 250, 000 - <400, 000 lb, 2022: 250, 2021: 250, 2020: 50, 000 - <250, Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Isoborneol:, Table: National Aggregate Production Volume (pounds) [Table#4224], General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing, Not Known or Reasonably Ascertainable, Plastics Material and Resin Manufacturing, Soap, Cleaning Compound, and Toilet Preparation Manufacturing, Bicyclo[2.2.1]heptan-2-ol, 1, 7, 7-trimethyl-, (1R, 2R, 4R)-rel-: ACTIVE, Borneol is an endo isomer, the corresponding exo isomer is isoborneol, Natural occurrence: Ashanti pepper (Piper guineense Schum and Thom) Ginger (Zingiber species) Grape brandy Camomile Honey Cheese, various types Mastic (Pistacia lentiscus) Cinnamomum species Ocimum species Curcuma species Papaya (Carica papaya L.) Eucalyptus oil (Eucalyptus globulus Labill) Raspberry, blackberry and boysenberry Rooibos tea (Aspalathus linearis) Salvia species Rosemary (Rosmarinus officinalis L.) Thyme (Thymus species).
Category: Organic Chemicals.
Independent reference data for (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2α-ol (CAS 10334-13-1), compiled from public chemistry databases.
| CAS 号 | 10334-13-1 |
|---|---|
| PubChem CID | 6321405 |
| 分子式 | C10H18O |
| IUPAC 名称 | (1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol |
| UNII（FDA） | L88RA8N5EG |
| FEMA 编号 | 2158 |
| JECFA 编号 | 1386 |
| Molecular Weight | 154.25 |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 154.135765193 |
| Monoisotopic Mass | 154.135765193 |
| Topological Polar Surface Area | 20.2 |
| Heavy Atom Count | 11 |
| Melting Point | 216 °C |
|---|---|
| Melting Point | 212 °C |
| Density | 1.10 g/cm cu at 20 °C |
| Vapor Pressure | 0.03 [mmHg] |
| LogP | log Kow = 3.24 |
Isoborneol; 124-76-5; Isocamphol; Isobornyl alcohol; 2-exo-Bornyl alcohol; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1R,2R,4R)-rel-; FEMA No. 2158; DTXSID2042060; L88RA8N5EG; DTXCID0022060; NSC-26350; Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1R,2R,4R)-rel-; RefChem:5910; 204-712-4; (-)-Isoborneol; DL-Isoborneol
| 法规与食品接触 | EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent Camphor, Must No safety concern at current levels of intake when used as a flavouring agent |
|---|
| 已通报的危害声明 | H228 (99.6%), H315 (11.4%) |
|---|
(1R,4R)-1,7,7-三甲基双环[2.2.1]庚-2α-醇 · CAS 10334-13-1 · C10H18O. UNII L88RA8N5EG. Melting Point: 216 °C; Melting Point: 212 °C; Density: 1.10 g/cm cu at 20 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.