1-hydroxyanthraquinone

Description

1-hydroxyanthraquinone · CAS 129-43-1 · C14H8O3. UNII LFU129OE9H. Melting Point: 193.8 °C; Solubility: In water, 8.5 mg/L @ 25 °C; Vapor Pressure: 0.00000021 [mmHg].

Identification

CAS Registry Number	129-43-1
PubChem CID	8512
Molecular formula	C14H8O3
IUPAC name	1-hydroxyanthracene-9,10-dione
UNII (FDA)	LFU129OE9H

Computed Descriptors

Molecular Weight	224.21
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	224.047344113
Monoisotopic Mass	224.047344113
Topological Polar Surface Area	54.4
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	193.8 °C
Solubility	In water, 8.5 mg/L @ 25 °C
Vapor Pressure	0.00000021 [mmHg]
Vapor Pressure	2.09X10-7 mm Hg @ 25 °C
LogP	log Kow = 3.52
LogP	3.52

Physical description & handling notes

• Orange-red to yellow solid; [HSDB] Orange powder; [MSDSonline]
• Orange red needles
• Red-orange needles from ethyl alcohol
• Orange-red to fine yellow crystals in ethanol
• Sublimes
• Soluble in ethanol, ethyl ether, and benzene.

GHS Hazard Classification

Reported hazard statements	H319 (100%), H351 (100%), H320

Documented Uses

• Used to make dyes and pharmaceuticals; [HSDB]
• 1-Hydroxyanthraquinone can be used as an intermediate in the production of dyes and drugs.
• A general method for synthesis of anthraquinones, including 1-hydroxy-anthraquinone, has been developed. The anthraquinones were obtained under mild conditions from ortho-dicarboxylic acid chlorides and suitable aromatic substrates via a FriedelCrafts process.
• 1-Hydroxyanthraquinone has been synthesized by diazotization of 1-aminoanthraquinone and heating the diazonium salt with concentrated sulfuric acid. After dilution with water, the precipitated crude product was diluted with acetone and purified by preparative thin-layer chromatography (TLC) in toluene:ethyl formate:formic acid (75:24:1).
• 1-Hydroxyanthraquinone has also been prepared in 96.4% yield by reacting 1-nitroanthraquinone with sodium formate in dimethylformamide at 130 C for 17 hours.
• 9,10-Anthracenedione, 1-hydroxy-: INACTIVE

Synonyms

1-HYDROXYANTHRAQUINONE; 129-43-1; 1-hydroxyanthracene-9,10-dione; 9,10-Anthracenedione, 1-hydroxy-; 1-Hydroxy-9,10-anthraquinone; Hydroxyanthraquinone; 1-Hydroxyanthrachinon; Anthraquinone, 1-hydroxy-; alpha-Hydroxyanthraquinone; LFU129OE9H; 1-hydroxy-9,10-anthracenedione; CHEBI:28877; NSC-8640; DTXSID1020722; RefChem:76013; DTXCID70722

Frequently Asked Questions

What are the CAS number and molecular formula of 1-hydroxyanthraquinone?

CAS 129-43-1; molecular formula C14H8O3; molecular weight — g/mol.

What other names is 1-hydroxyanthraquinone known by?

1-HYDROXYANTHRAQUINONE, 129-43-1, 1-hydroxyanthracene-9,10-dione, 9,10-Anthracenedione, 1-hydroxy-, 1-Hydroxy-9,10-anthraquinone, Hydroxyanthraquinone.

Is 1-hydroxyanthraquinone classified as hazardous?

Hazard statements reported: H319, H351, H320.

What are the key physical properties of 1-hydroxyanthraquinone?

Melting Point: 193.8 °C; Solubility: In water, 8.5 mg/L @ 25 °C; Vapor Pressure: 0.00000021 [mmHg]; Vapor Pressure: 2.09X10-7 mm Hg @ 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.