1,1,1,2,3,3,3-Heptafluoropropane (CAS 431-89-0) — formula C3HF7, molecular weight 170.03; category organic chemicals.
| CAS Number | 431-89-0 |
|---|---|
| Molecular Formula | C3HF7 |
| Molecular Weight | 170.03 |
| Melting Point | -126.8 °C |
| Boiling Point | -16.34 °C |
| LogP | 2.22 |
| Applications | Uses: ... HFC 227ea can be used as ..., a propellant, in medicinal aerosols instead of CFC 114., HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems, as a fire suppressant, and for pharmaceutical aerosols and metered-dose inhalers., Propellants for medical sprays including: MDIs (Metered Dose Inhalers) also known as pharmaceutical aerosols or asthma sprays for the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disorder) and respiratory infections, nasal sprays for the treatment of allergic rhinitis, foam sprays, oral and topical sprays (e.g. nerve sensitization, tooth vitality, pain relaxation)., Industry Uses: Propellants, non-motive (blowing agents), Fire extinguishing agent, Consumer Uses: Propellants, Flame retardant, Methods of Manufacturing: The method for the manufacture of HFC-1, 1, 2, 3, 3-heptafluoropropane involves the addition of HF to hexafluoropropene in the gas phase. The best gas-phase catalyst is Cr2O3, derived from the pyrolysis of ammonium dichromate. This catalyst is known to have a very high surface area (>200 sq m, g) and large pore volume (0.25 cm3, g). ... Under these conditions, the product obtained contains < 10 ppm of the highly toxic perfluoroisobutylene. Activated carbon, which has a very high surface area (500-1500 sq m, g), was found to be very selective in adsorbing perfluoroisobutylene in the presence of heptafluoropropane. The fluorination of hexafluoropropylene can also be carried out in the liquid phase, using SbF5 or tributylamine as the catalysts, to produce very high purity heptafluoropropane (>99.95% and 99.999%, respectively) without the formation of perfluoroisobutylene., Monohydroperfluoroalkanes can be obtained by adding hydrogen fluoride to perfluoroalkenes (e.g., CF3-CHF-CF3, HFC 227ea) or by decarboxylation of perfluorocarboxylates in the presence of proton donors., Formulations, Preparations: Solkane 227 Pharma (Solvay), U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 4, 000 - <5, 2020: 2, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7535], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Propane, 3-heptafluoro-. Aggregated National Production Volume: 1 to < 10 million pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Propane, 3-heptafluoro-. National Production Volume: Withheld., General Manufacturing Information: Machinery Manufacturing, Pharmaceutical and Medicine Manufacturing, Propane, 3-heptafluoro-: ACTIVE, The phase-out of production of Halons on December 31, 1993, resulted from the regulation of Halon 1301 under the Montreal Protocol on Substances that Deplete Stratospheric Ozone [6]. As a result, research and development across the world lead to the development of over 12 commercialized clean agent alternatives to Halon 1301. ... Clean fire suppression agents are defined as those agents that vaporize readily and leave no residue. Hydrocarbon clean agents, based on the characteristics of the agents, extinguish fires by interrupting the chemical chain reaction of fire, and through extracting heat from the flame of a fire, reducing flame temperature leading to extinguishment of the flame. Heptafluoropropane (Trade Name: FM 200, Designation: HFC227ea), is a Halon replacement, ., There is only one other isomer, 3-heptfluoropropane (HFC 227 ca)., Great Lakes Chemical Company, in a joint venture with INEOS Fluor, has agreed to produce a pharmaceutical grade 1, 3-heptafluoropropane (HFC-227ea) as aerosol propellant for an asthma inhalation drug. |
| Category | Organic Chemicals |
Documented applications: Uses: ... HFC 227ea can be used as ..., a propellant, in medicinal aerosols instead of CFC 114., HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems, as a fire suppressant, and for pharmaceutical aerosols and metered-dose inhalers., Propellants for medical sprays including: MDIs (Metered Dose Inhalers) also known as pharmaceutical aerosols or asthma sprays for the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disorder) and respiratory infections, nasal sprays for the treatment of allergic rhinitis, foam sprays, oral and topical sprays (e.g. nerve sensitization, tooth vitality, pain relaxation)., Industry Uses: Propellants, non-motive (blowing agents), Fire extinguishing agent, Consumer Uses: Propellants, Flame retardant, Methods of Manufacturing: The method for the manufacture of HFC-1, 1, 2, 3, 3-heptafluoropropane involves the addition of HF to hexafluoropropene in the gas phase. The best gas-phase catalyst is Cr2O3, derived from the pyrolysis of ammonium dichromate. This catalyst is known to have a very high surface area (>200 sq m, g) and large pore volume (0.25 cm3, g). ... Under these conditions, the product obtained contains < 10 ppm of the highly toxic perfluoroisobutylene. Activated carbon, which has a very high surface area (500-1500 sq m, g), was found to be very selective in adsorbing perfluoroisobutylene in the presence of heptafluoropropane. The fluorination of hexafluoropropylene can also be carried out in the liquid phase, using SbF5 or tributylamine as the catalysts, to produce very high purity heptafluoropropane (>99.95% and 99.999%, respectively) without the formation of perfluoroisobutylene., Monohydroperfluoroalkanes can be obtained by adding hydrogen fluoride to perfluoroalkenes (e.g., CF3-CHF-CF3, HFC 227ea) or by decarboxylation of perfluorocarboxylates in the presence of proton donors., Formulations, Preparations: Solkane 227 Pharma (Solvay), U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 4, 000 - <5, 2020: 2, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7535], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Propane, 3-heptafluoro-. Aggregated National Production Volume: 1 to < 10 million pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Propane, 3-heptafluoro-. National Production Volume: Withheld., General Manufacturing Information: Machinery Manufacturing, Pharmaceutical and Medicine Manufacturing, Propane, 3-heptafluoro-: ACTIVE, The phase-out of production of Halons on December 31, 1993, resulted from the regulation of Halon 1301 under the Montreal Protocol on Substances that Deplete Stratospheric Ozone [6]. As a result, research and development across the world lead to the development of over 12 commercialized clean agent alternatives to Halon 1301. ... Clean fire suppression agents are defined as those agents that vaporize readily and leave no residue. Hydrocarbon clean agents, based on the characteristics of the agents, extinguish fires by interrupting the chemical chain reaction of fire, and through extracting heat from the flame of a fire, reducing flame temperature leading to extinguishment of the flame. Heptafluoropropane (Trade Name: FM 200, Designation: HFC227ea), is a Halon replacement, ., There is only one other isomer, 3-heptfluoropropane (HFC 227 ca)., Great Lakes Chemical Company, in a joint venture with INEOS Fluor, has agreed to produce a pharmaceutical grade 1, 3-heptafluoropropane (HFC-227ea) as aerosol propellant for an asthma inhalation drug..
1,1,1,2,3,3,3-Heptafluoropropane is a carbon-based organic compound with CAS registry number 431-89-0 and molecular formula C3HF7 (molecular weight 170.03), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 431-89-0
Its molecular formula C3HF7 comprises 3 C, 1 H, 7 F atoms.
Also known as: 1,1,1,2,3,3,3-Heptafluoropropane · 1,1,1,2,3,3,3-七氟丙烷
Category: organic chemicals
The CAS registry number of 1,1,1,2,3,3,3-Heptafluoropropane is 431-89-0.
Molecular formula C3HF7, molecular weight 170.03.
It is also registered under: 1,1,1,2,3,3,3-Heptafluoropropane, 1,1,1,2,3,3,3-七氟丙烷.
Recorded applications: Uses: ... HFC 227ea can be used as ..., a propellant, in medicinal aerosols instead of CFC 114., HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems, as a fire suppressant, and for pharmaceutical aerosols and metered-dose inhalers., Propellants for medical sprays including: MDIs (Metered Dose Inhalers) also known as pharmaceutical aerosols or asthma sprays for the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disorder) and respiratory infections, nasal sprays for the treatment of allergic rhinitis, foam sprays, oral and topical sprays (e.g. nerve sensitization, tooth vitality, pain relaxation)., Industry Uses: Propellants, non-motive (blowing agents), Fire extinguishing agent, Consumer Uses: Propellants, Flame retardant, Methods of Manufacturing: The method for the manufacture of HFC-1, 1, 2, 3, 3-heptafluoropropane involves the addition of HF to hexafluoropropene in the gas phase. The best gas-phase catalyst is Cr2O3, derived from the pyrolysis of ammonium dichromate. This catalyst is known to have a very high surface area (>200 sq m, g) and large pore volume (0.25 cm3, g). ... Under these conditions, the product obtained contains < 10 ppm of the highly toxic perfluoroisobutylene. Activated carbon, which has a very high surface area (500-1500 sq m, g), was found to be very selective in adsorbing perfluoroisobutylene in the presence of heptafluoropropane. The fluorination of hexafluoropropylene can also be carried out in the liquid phase, using SbF5 or tributylamine as the catalysts, to produce very high purity heptafluoropropane (>99.95% and 99.999%, respectively) without the formation of perfluoroisobutylene., Monohydroperfluoroalkanes can be obtained by adding hydrogen fluoride to perfluoroalkenes (e.g., CF3-CHF-CF3, HFC 227ea) or by decarboxylation of perfluorocarboxylates in the presence of proton donors., Formulations, Preparations: Solkane 227 Pharma (Solvay), U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 4, 000 - <5, 2020: 2, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7535], Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Propane, 3-heptafluoro-. Aggregated National Production Volume: 1 to < 10 million pounds., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Propane, 3-heptafluoro-. National Production Volume: Withheld., General Manufacturing Information: Machinery Manufacturing, Pharmaceutical and Medicine Manufacturing, Propane, 3-heptafluoro-: ACTIVE, The phase-out of production of Halons on December 31, 1993, resulted from the regulation of Halon 1301 under the Montreal Protocol on Substances that Deplete Stratospheric Ozone [6]. As a result, research and development across the world lead to the development of over 12 commercialized clean agent alternatives to Halon 1301. ... Clean fire suppression agents are defined as those agents that vaporize readily and leave no residue. Hydrocarbon clean agents, based on the characteristics of the agents, extinguish fires by interrupting the chemical chain reaction of fire, and through extracting heat from the flame of a fire, reducing flame temperature leading to extinguishment of the flame. Heptafluoropropane (Trade Name: FM 200, Designation: HFC227ea), is a Halon replacement, ., There is only one other isomer, 3-heptfluoropropane (HFC 227 ca)., Great Lakes Chemical Company, in a joint venture with INEOS Fluor, has agreed to produce a pharmaceutical grade 1, 3-heptafluoropropane (HFC-227ea) as aerosol propellant for an asthma inhalation drug..
Category: Organic Chemicals.
Independent reference data for 1,1,1,2,3,3,3-Heptafluoropropane (CAS 431-89-0), compiled from public chemistry databases.
| CAS Registry Number | 431-89-0 |
|---|---|
| PubChem CID | 67940 |
| Molecular formula | C3HF7 |
| IUPAC name | 1,1,1,2,3,3,3-heptafluoropropane |
| UNII (FDA) | R40P36GDK6 |
| Molecular Weight | 170.03 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 0 |
| Exact Mass | 169.99664717 |
| Monoisotopic Mass | 169.99664717 |
| Topological Polar Surface Area | 0 |
| Heavy Atom Count | 10 |
| Boiling Point | -16.34 °C |
|---|---|
| Melting Point | -126.8 °C |
| Density | 1.394 g/cu cm at 25 °C |
| Vapor Density | 4.2 at 20 °C (Air = 1) |
| Vapor Pressure | VP: 390 kPa at 20 °C |
| Vapor Pressure | 3.41X10+3 mm Hg at 25 °C |
| LogP | 2.22 |
1,1,1,2,3,3,3-Heptafluoropropane; 431-89-0; Apaflurane; 2H-Heptafluoropropane; HFC-227ea; Solkane 227; 2-Hydroheptafluoropropane; HFA-227; Propane, 1,1,1,2,3,3,3-heptafluoro-; Khladon 227; HFC-227; 2-Hydroperfluoropropane; HFC 227; Apaflurano; FM 200; HFA-227EA
| GHS notification summary | 8.6% (24 / 279) |
|---|
| GHS notification summary | 8.6% (24 / 279) |
|---|---|
| Reported hazard statements | H280 (91.4%) |
This chemical does not meet GHS hazard criteria for 8.6% (24 of 279) of reports.
H280 (91.4%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]
1,1,1,2,3,3,3-Heptafluoropropane · CAS 431-89-0 · C3HF7. UNII R40P36GDK6. Boiling Point: -16.34 °C; Melting Point: -126.8 °C; Density: 1.394 g/cu cm at 25 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 1,1,1,2,3,3,3-七氟丙烷