Fmoc Tranexamic Acid (CAS 167690-53-1) Sourcing Notes: Protecting-Group Choice & Acceptance Details for Peptide Work
People working on peptide synthesis know tranexamic acid well, but before placing an order most will ask: what is the real difference between Fmoc Tranexamic Acid (CAS 167690-53-1) and the free amino acid, and which parameters should I watch when buying? This page breaks that down from a sourcing perspective.
1. Basic specifications
| Product name | Fmoc Tranexamic Acid (Fmoc-protected tranexamic acid) |
|---|---|
| CAS No. | 167690-53-1 |
| Formula | C23H25NO4 |
| Molecular weight | 379.4 |
| LogP | 4.1 |
| Applications | Organic chemicals / peptide synthesis intermediates |
| Standard purity | per batch COA |
| Packaging | confirmed per order |
| Storage | keep sealed in a cool, dry place |
Figures above are published / typical information; final values follow the batch COA and order confirmation.
2. Why the Fmoc-protected form
Tranexamic acid carries both a carboxyl and an amino group. If the amino group is left unprotected, direct coupling leads to unwanted reactions and a messier crude product that costs more to purify. Fmoc (9-fluorenylmethoxycarbonyl) is one of the most widely used amino protecting groups in solid-phase peptide synthesis: base-labile, acid-stable, and removable under standard piperidine treatment, so it fits ordinary Fmoc/tBu strategies.
So define the use first. If the goal is peptide modification or SAR work in the pharma intermediates direction, buying the Fmoc-protected form saves one protection step and one purification loss. If the free amino acid itself is the starting point for other transformations, the unprotected material is the right buy. The CAS number pins down one defined structure, so thinking this through before requesting a quote makes the whole conversation faster.
3. Incoming-inspection checklist
- Assay and protecting-group integrity: besides HPLC purity, check how much Fmoc is still intact; batches with excessive deprotection hurt later coupling efficiency.
- Chirality and related impurities: tranexamic acid chemistry can carry isomeric impurities; verify chiral purity and related-substance items against R&D or filing requirements.
- Residuals and loss on drying: moisture and residual solvents matter for scale-up charging calculations.
- COA and retain samples: request the batch COA and retain samples of critical lots for traceability.
Like most Fmoc amino-acid derivatives, the shared risk is protecting-group stability. A supplier with stable batches and complete test data is usually worth more than the lowest price alone.
4. Storage and handling
The Fmoc group is base-labile. Keep the material sealed in a cool, dry place away from strongly alkaline environments and prolonged strong light; use opened containers promptly to avoid moisture pickup. Packaging and storage requirements follow the batch COA and order confirmation.
5. FAQ
Which parameters matter when sourcing Fmoc Tranexamic Acid?
Confirm the CAS number (167690-53-1), Fmoc protecting-group integrity, chiral purity, residual tranexamic acid, loss on drying and residual solvents; final values follow the batch COA.
Why is Fmoc Tranexamic Acid preferred over the unprotected amino acid in peptide work?
Tranexamic acid contains a free amino group that causes side reactions in direct coupling. Fmoc protection blocks that site and is removed under standard Fmoc deprotection conditions, reducing by-products and simplifying purification.
How should Fmoc Tranexamic Acid be stored?
Keep sealed in a cool, dry place, away from prolonged alkaline conditions and strong light; packaging and storage follow the batch COA and order confirmation.
6. Related products
- Fmoc-D-2-cyanophenylalanine (CAS 401620-74-4)
- 3-Fmoc-amino-pyrrolidine hydrochloride (CAS 400653-43-2)
- Fmoc-(S)-3-amino-4-(4-tert-butylphenyl)-butyric acid (CAS 403661-8)
More Fmoc derivatives: site search for Fmoc, or browse the Organic Chemicals directory.
7. Supplier & compliance
Jinan Shenghe Chemical Co., Ltd. is based in Jinan, Shandong, and supplies organic chemicals and fine-chemical raw materials with a COA for every shipment; quotations are returned within one business day.
Enquiries: info@591daili.com | +86-18553102138
Note: This page is for industrial raw-material and R&D technical discussion only. Products are supplied for industrial and research use, not for consumer or medical use. Pharmaceutical, food or cosmetic applications must meet applicable regulations and customer standards; specifications, compliance documents and transport requirements follow the batch COA and order confirmation.