1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷（CAS 53-19-0）：分子式 C14H10Cl4、分子量 320.0。
| CAS号 | 53-19-0 |
|---|---|
| 分子式 | C14H10Cl4 |
| 分子量 | 320.0 |
| 熔点 | 171 to 172 °F (NTP, 1992) |
| LogP | 5.34 |
| 应用领域 | Uses: Used to induce chemical adrenalectomies in patients having adrenal cancer by reducing host levels of adrenocorticosteroids、o、p'-DDD (Mitotane) is produced under the name Lysodren for use as a chemotherapy agent for adrenal gland cancer.、THERAP CAT: Antineoplastic、MEDICATION、Use (kg、approx.) in Germany (2009): >100、exact) in Germany (2009): 113、Consumption (g per capita、approx.) in Germany (2009): 0.00122、exact) in Germany (2009): 0.00137、Calculated removal (%): 91.5、DDD is found in DDT、which is used as a pesticide and in disease vector control. (L84). It is also used for treatment of inoperable adrenocortical tumours、Cushing's syndrome、Methods of Manufacturing:、Synthesized from、dichloroacetaldehyde and its acetals.、Constituent of commercial DDD which contains about 10% of this o、p'-isomer. Prepn from 2、2-dichloro-1-(o-chlorophenyl)ethanol with chlorobenzene in presence of H2SO4.、Formulations、Preparations: Formulations: (AHFS、2009)、Table: Formulations: (AHFS、2009)Route [Table#4503]、General Manufacturing Information: Mitotane is a metabolite of DDT |
登记用途：Uses: Used to induce chemical adrenalectomies in patients having adrenal cancer by reducing host levels of adrenocorticosteroids、o、p'-DDD (Mitotane) is produced under the name Lysodren for use as a chemotherapy agent for adrenal gland cancer.、THERAP CAT: Antineoplastic、MEDICATION、Use (kg、approx.) in Germany (2009): >100、exact) in Germany (2009): 113、Consumption (g per capita、approx.) in Germany (2009): 0.00122、exact) in Germany (2009): 0.00137、Calculated removal (%): 91.5、DDD is found in DDT、which is used as a pesticide and in disease vector control. (L84). It is also used for treatment of inoperable adrenocortical tumours、Cushing's syndrome、Methods of Manufacturing:、Synthesized from、dichloroacetaldehyde and its acetals.、Constituent of commercial DDD which contains about 10% of this o、p'-isomer. Prepn from 2、2-dichloro-1-(o-chlorophenyl)ethanol with chlorobenzene in presence of H2SO4.、Formulations、Preparations: Formulations: (AHFS、2009)、Table: Formulations: (AHFS、2009)Route [Table#4503]、General Manufacturing Information: Mitotane is a metabolite of DDT。
1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷 是一种化工化合物，登记 CAS 号为 53-19-0，分子式 C14H10Cl4（分子量 320.0）。
登记 CAS 号：53-19-0
其分子式 C14H10Cl4 由 14 个碳、10 个氢、4 个氯 组成。
别名/同义词：1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷 · 1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane
1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷 的 CAS 登记号为 53-19-0。
分子式 C14H10Cl4，分子量 320.0。
别名/同义词：1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷、1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane。
登记用途：Uses: Used to induce chemical adrenalectomies in patients having adrenal cancer by reducing host levels of adrenocorticosteroids、o、p'-DDD (Mitotane) is produced under the name Lysodren for use as a chemotherapy agent for adrenal gland cancer.、THERAP CAT: Antineoplastic、MEDICATION、Use (kg、approx.) in Germany (2009): >100、exact) in Germany (2009): 113、Consumption (g per capita、approx.) in Germany (2009): 0.00122、exact) in Germany (2009): 0.00137、Calculated removal (%): 91.5、DDD is found in DDT、which is used as a pesticide and in disease vector control. (L84). It is also used for treatment of inoperable adrenocortical tumours、Cushing's syndrome、Methods of Manufacturing:、Synthesized from、dichloroacetaldehyde and its acetals.、Constituent of commercial DDD which contains about 10% of this o、p'-isomer. Prepn from 2、2-dichloro-1-(o-chlorophenyl)ethanol with chlorobenzene in presence of H2SO4.、Formulations、Preparations: Formulations: (AHFS、2009)、Table: Formulations: (AHFS、2009)Route [Table#4503]、General Manufacturing Information: Mitotane is a metabolite of DDT。
1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷（CAS 53-19-0）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 53-19-0 |
|---|---|
| PubChem CID | 4211 |
| Molecular formula | C14H10Cl4 |
| IUPAC name | 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene |
| UNII (FDA) | 78E4J5IB5J |
| Molecular Weight | 320.0 |
|---|---|
| XLogP3 | 6.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 3 |
| Exact Mass | 319.950711 |
| Monoisotopic Mass | 317.953661 |
| Topological Polar Surface Area | 0 |
| Heavy Atom Count | 18 |
| Melting Point | 171 to 172 °F (NTP, 1992) |
|---|---|
| Melting Point | 77 |
| Melting Point | 77 °C |
| Solubility | 0.1 |
| Solubility | In water, 0.10 mg/L at 25 °C |
| Solubility | 9.42e-06 g/L |
| Vapor Pressure | 1.94X10-6 mm Hg at 25 °C |
| LogP | 5.34 |
mitotane; 53-19-0; Mitotan; Lysodren; Chlodithane; Chloditan; o,p'-DDD; 2,4'-Ddd; Mitotano; Opeprim; o,p'-TDE; 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; o,p-Tde; Mitotanum; NCI-C04933
| GHS notification summary | 6.5% (3 / 46) |
|---|
| GHS notification summary | 6.5% (3 / 46) |
|---|---|
| Reported hazard statements | H351 (93.5%), H336, H370, H372 |
This chemical does not meet GHS hazard criteria for 6.5% (3 of 46) of reports.
H351 (93.5%): Suspected of causing cancer [Warning Carcinogenicity]
1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane · CAS 53-19-0 · C14H10Cl4. UNII 78E4J5IB5J. Melting Point: 171 to 172 °F (NTP, 1992); Melting Point: 77; Melting Point: 77 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: 1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane