2,2'-二羟基-4-甲氧基二苯甲酮

Description

2,2'-dihydroxy-4-methoxybenzophenone · CAS 131-53-3 · C14H12O4. UNII B762XZ551X. Boiling Point: 338 to 347 °F at 1 mmHg (NTP, 1992); Boiling Point: 172.5; Boiling Point: BP: 172 °C at 1 mm Hg.

Identification

CAS Registry Number	131-53-3
PubChem CID	8569
Molecular formula	C14H12O4
IUPAC name	(2-hydroxy-4-methoxyphenyl)-(2-hydroxyphenyl)methanone
UNII (FDA)	B762XZ551X

Computed Descriptors

Molecular Weight	244.24
XLogP3	3.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	244.07355886
Monoisotopic Mass	244.07355886
Topological Polar Surface Area	66.8
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Boiling Point	338 to 347 °F at 1 mmHg (NTP, 1992)
Boiling Point	172.5
Boiling Point	BP: 172 °C at 1 mm Hg
Melting Point	74
Melting Point	68 °C
Melting Point	MP: 70.6-77.2 °C
Density	1.39 g/cu cm at 22.7 °C

Physical description & handling notes

• 2,2'-dihydroxy-4-methoxybenzophenone is a yellow powder. (NTP, 1992)
• Dry Powder
• Yellow powder
• Practically insoluble in water
• Solubility in g/100 mL at 25 °C: ethanol 21.8; isopropanol 17; propylene glycol6.2; ethylene glycol 3.0; n-hexane 1.5
• Freely soluble in alcohol, toluene

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Cosmetic ingredients (Benzophenone-8) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Uv absorber
GHS notification summary	9.8% (5 / 51)

GHS Hazard Classification

GHS notification summary	9.8% (5 / 51)
Reported hazard statements	H315 (84.3%), H319 (84.3%), H335 (80.4%)

Documented Uses

• Broad-spectrum sunscreens often contain a number of chemical ingredients that absorb UVA and UVB radiation. Many sunscreens contain UVA-absorbing avobenzone or a benzophenone (such as dioxybenzone, oxybenzone, or sulisobenzone), in addition to UVB-absorbing chemical ingredients (some of which also contribute to UVA protection).
• Cosmetic Ultraviolet Absorber: benzophenone-8. /From table/
• Preparation: Hardy et al., United States of America patent 2853521 (1958 to American Cyanamid).
• Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-:
• Table: National Aggregate Production Volume (pounds) [Table#8583]
• Plastics Material and Resin Manufacturing

Synonyms

dioxybenzone; 131-53-3; 2,2'-DIHYDROXY-4-METHOXYBENZOPHENONE; Dioxybenzon; Spectra-sorb UV 24; Cyasorb UV 24; (2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone; Advastab 47; Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-; Dioxibenzona; Dioxibenzonum; Cyasorb UV 24 Light Absorber; UV 24; Dioxybenzonum; NSC-56769; DTXSID3022403

Frequently Asked Questions

What are the CAS number and molecular formula of 2,2'-dihydroxy-4-methoxybenzophenone?

CAS 131-53-3; molecular formula C14H12O4; molecular weight — g/mol.

What other names is 2,2'-dihydroxy-4-methoxybenzophenone known by?

dioxybenzone, 131-53-3, 2,2'-DIHYDROXY-4-METHOXYBENZOPHENONE, Dioxybenzon, Spectra-sorb UV 24, Cyasorb UV 24.

What is the regulatory status of 2,2'-dihydroxy-4-methoxybenzophenone?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Benzophenone-8) -> CIR (Cosmetic Ingredient Review); CIR / INCI: Uv absorber.

Is 2,2'-dihydroxy-4-methoxybenzophenone classified as hazardous?

9.8% of GHS notifications report no hazard classification (5 of 51).

What are the key physical properties of 2,2'-dihydroxy-4-methoxybenzophenone?

Boiling Point: 338 to 347 °F at 1 mmHg (NTP, 1992); Boiling Point: 172.5; Boiling Point: BP: 172 °C at 1 mm Hg; Melting Point: 74.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.