Bisoprolol

CAS 66722-44-9C18H31NO4MW 325.4

Bisoprolol (CAS 66722-44-9) — formula C18H31NO4, molecular weight 325.4.

Product Overview

CAS Number	66722-44-9
Molecular Formula	C18H31NO4
Molecular Weight	325.4
Melting Point	100-103
Boiling Point	445.0±45.0
LogP	2.2
Applications	Uses: MEDICATION, Adrenergic beta-1 Receptor Antagonists, Antihypertensive Agents, Sympatholytics, Use (kg, approx.) in Germany (2009): >7500, exact) in Germany (2009): 8196, Use (kg) in USA (2002): 600, Use (kg) in France (2004): 2113, Consumption (g per capita, approx.) in Germany (2009): 0.0916, exact) in Germany (2009): 0.1, Consumption (g per capita) in the USA (2002): 0.00213, Consumption (g per capita) in France (2004): 0.035, Excretion rate: 0.6, Calculated removal (%): 22.7, Use Classification: Pharmaceuticals, Methods of Manufacturing: Preparation: Belgium patent 859425, R. Jonas et al., United States of America patent 4258062 (1978, 1981 both to E. Merck)., Formulations, Preparations: Table: Bisoprolol Fumarate Preparations [Table#8328], Table: Bisoprolol Fumarate Combination Preparations [Table#8329]

Applications

Documented applications: Uses: MEDICATION, Adrenergic beta-1 Receptor Antagonists, Antihypertensive Agents, Sympatholytics, Use (kg, approx.) in Germany (2009): >7500, exact) in Germany (2009): 8196, Use (kg) in USA (2002): 600, Use (kg) in France (2004): 2113, Consumption (g per capita, approx.) in Germany (2009): 0.0916, exact) in Germany (2009): 0.1, Consumption (g per capita) in the USA (2002): 0.00213, Consumption (g per capita) in France (2004): 0.035, Excretion rate: 0.6, Calculated removal (%): 22.7, Use Classification: Pharmaceuticals, Methods of Manufacturing: Preparation: Belgium patent 859425, R. Jonas et al., United States of America patent 4258062 (1978, 1981 both to E. Merck)., Formulations, Preparations: Table: Bisoprolol Fumarate Preparations [Table#8328], Table: Bisoprolol Fumarate Combination Preparations [Table#8329].

Technical Profile

What this product is

Bisoprolol is a chemical compound with CAS registry number 66722-44-9 and molecular formula C18H31NO4 (molecular weight 325.4).

Identification

CAS number: 66722-44-9

Its molecular formula C18H31NO4 comprises 18 C, 31 H, 1 N, 4 O atoms.

Also known as: Bisoprolol · 比索洛尔 · 1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol

Frequently Asked Questions

What is the CAS number of Bisoprolol?

The CAS registry number of Bisoprolol is 66722-44-9.

What is the molecular formula and molecular weight of Bisoprolol?

Molecular formula C18H31NO4, molecular weight 325.4.

What other names is Bisoprolol known by?

It is also registered under: Bisoprolol, 比索洛尔, 1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol.

What are the documented applications of Bisoprolol?

Recorded applications: Uses: MEDICATION, Adrenergic beta-1 Receptor Antagonists, Antihypertensive Agents, Sympatholytics, Use (kg, approx.) in Germany (2009): >7500, exact) in Germany (2009): 8196, Use (kg) in USA (2002): 600, Use (kg) in France (2004): 2113, Consumption (g per capita, approx.) in Germany (2009): 0.0916, exact) in Germany (2009): 0.1, Consumption (g per capita) in the USA (2002): 0.00213, Consumption (g per capita) in France (2004): 0.035, Excretion rate: 0.6, Calculated removal (%): 22.7, Use Classification: Pharmaceuticals, Methods of Manufacturing: Preparation: Belgium patent 859425, R. Jonas et al., United States of America patent 4258062 (1978, 1981 both to E. Merck)., Formulations, Preparations: Table: Bisoprolol Fumarate Preparations [Table#8328], Table: Bisoprolol Fumarate Combination Preparations [Table#8329].

PubChem Public Data

Independent reference data for Bisoprolol (CAS 66722-44-9), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	66722-44-9
PubChem CID	2405
Molecular formula	C18H31NO4
IUPAC name	1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
UNII (FDA)	Y41JS2NL6U

Computed descriptors

Molecular Weight	325.4
XLogP3	1.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	12
Exact Mass	325.22530847
Monoisotopic Mass	325.22530847
Topological Polar Surface Area	60
Heavy Atom Count	23

Physicochemical values on record

Boiling Point	445.0±45.0
Melting Point	100-103
Melting Point	100 °C
Solubility	7.07e-02 g/L
LogP	2.2
LogP	log Kow = 1.87
LogP	1.87
Dissociation Constants	9.57
Dissociation Constants	9.5

Documented uses on record

Synonyms and trade names

BISOPROLOL; 66722-44-9; Bisoprololum; Bisocor; Bisoprololum [Latin]; EMD 33 512; Y41JS2NL6U; (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol; (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; CL 297939; CHEBI:3127; DTXSID6022682; Bisoprololum (Latin); [2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine; 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-; bisoprololo

GHS hazard classification

Reported hazard statements	H302 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

What the public record says

1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol · CAS 66722-44-9 · C18H31NO4. UNII Y41JS2NL6U. Boiling Point: 445.0±45.0; Melting Point: 100-103; Melting Point: 100 °C.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.