长春新碱

Description

vincristine · CAS 57-22-7 · C46H56N4O10. UNII 5J49Q6B70F. Melting Point: 424 to 428 °F (NTP, 1992); Melting Point: 220; Melting Point: 218-220 °C.

Identification

CAS Registry Number	57-22-7
PubChem CID	5978
Molecular formula	C46H56N4O10
UNII (FDA)	5J49Q6B70F

Computed Descriptors

Molecular Weight	825.0
XLogP3	2.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Exact Mass	824.39964400
Monoisotopic Mass	824.39964400
Topological Polar Surface Area	171
Heavy Atom Count	60
Formal Charge	0

Physical & Chemical Properties

Melting Point	424 to 428 °F (NTP, 1992)
Melting Point	220
Melting Point	218-220 °C
Melting Point	220 °C
Solubility	3.00e-02 g/L
LogP	2.82
LogP	log Kow = 2.82
LogP	2.8

Physical description & handling notes

• Vincristine appears as a white crystalline solid. Melting point 218 °C. Used as an antineoplastic.
• Solid
• Blades from methanol
• WHITE TO SLIGHTLY YELLOW, AMORPHOUS OR CRYSTALLINE POWDER; ODORLESS, HYGROSCOPIC; FREELY SOL IN WATER /VINCRISTINE SULFATE USP/
• STERILE SOLN IN EITHER H2O OR PHYSIOLOGICAL SALINE STORED IN REFRIGERATOR FOR UP TO 2 WK WITHOUT SIGNIFICANT LOSS OF POTENCY
• Specific optical rotation: +17 deg at 25 °C/D; +26.2 deg at 25 °C/D (ethylene chloride); max absorption (ethanol): 220, 255, 296 nm (log molar absorptivity = 4.65, 4.21, 4.18)

Documented Uses

• ... in the treatment of acute leukemia in children /Vincristine sulfate USP/
• Therapeutic Category: Antineoplastic
• Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
• Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.
• Isolation from Vinca rosea Linn (Catharanthus roseus G Don), Apocynaceae.
• USING SUITABLE MODIFICATIONS IN CHROMATOGRAPHIC PART OF PROCESS, VINCRISTINE SULFATE ISOLATING ALKALOID FROM EXTRACT BY USUAL PPT & SOLVENT TECHNIQUES & PURIFYING BY CHROMATOGRAPHY ON ALUMINUM OXIDE. CONVERSION TO SULFATE BY /ADDN OF SULFURIC ACID/ ... . /VINCRISTINE SULFATE/

Synonyms

vincristine; 22-Oxovincaleukoblastine; Leurocristine; Vinkristin; 57-22-7; Vincrystine; Vincristina; leucristine; vincristin; Tecnocris; Onco TCS; Oncovine; Oncotcs; Vincristinum; DTXSID1032278; NSC-67574

Frequently Asked Questions

What are the CAS number and molecular formula of vincristine?

CAS 57-22-7; molecular formula C46H56N4O10; molecular weight — g/mol.

What other names is vincristine known by?

vincristine, 22-Oxovincaleukoblastine, Leurocristine, Vinkristin, 57-22-7, Vincrystine.

What are the key physical properties of vincristine?

Melting Point: 424 to 428 °F (NTP, 1992); Melting Point: 220; Melting Point: 218-220 °C; Melting Point: 220 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.