Tiludronic acid

Description

Tiludronic acid · CAS 89987-06-4 · C7H9ClO6P2S. UNII 6PNS59HP4Y. Solubility: 6.97e+00 g/L; LogP: -3.8; LogP: -0.6.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Tiludronic acid is a bisphosphonate that prevents osteoclasts from resorbing bone. The duration of action is quite long due to the slow clearance from the bone, and the therapeutic window is wide. Patients should be counselled regarding the risk of upper GI mucosal irritation as well as gastric and duodenal ulcers.

Documented Uses

• Tiludronic acid is indicated to treat Paget's disease of bone in patients with serum alkaline phosphatase levels ≥2 times the upper limit of normal, with symptoms, or with risk of future complications.
• Breast Feeding; Lactation; Bisphosphonates; Bone Density Conservation Agents; Diphosphonates;
• Take at least 2 hours before or after calcium supplements.
• Take on an empty stomach. Take at least 2 hours before or after meals.
• Take separate from antacids. Take at least 2 hours before or after antacids. The bioavailability of this medication is significantly reduced when administered with aluminum or magnesium containing antacids.
• Take with a full glass of water.

Synonyms

Tiludronic Acid; Tiludronate; 89987-06-4; Acide tiludronique; Acido tiludronico; Acidum tiludronicum; SR-41319; [(4-chlorophenyl)sulfanyl-phosphonomethyl]phosphonic acid; {[(4-chlorophenyl)sulfanyl](phosphono)methyl}phosphonic acid; 6PNS59HP4Y; DTXSID10237966; (((p-Chlorophenyl)thio)methylene)diphosphonic acid; ((4-chlorophenyl)sulfanyl-phosphonomethyl)phosphonic acid; Tiludranate; (((4-chlorophenyl)sulfanyl)(phosphono)methyl)phosphonic acid; Cl2SMBP

Frequently Asked Questions

What are the CAS number and molecular formula of Tiludronic acid?

CAS 89987-06-4; molecular formula C7H9ClO6P2S; molecular weight — g/mol.

What other names is Tiludronic acid known by?

Tiludronic Acid, Tiludronate, 89987-06-4, Acide tiludronique, Acido tiludronico, Acidum tiludronicum.

What are the key physical properties of Tiludronic acid?

Solubility: 6.97e+00 g/L; LogP: -3.8; LogP: -0.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.