四甲基吡嗪

Description

2,3,5,6-Tetramethylpyrazine is identified by CAS 1124-11-4, molecular formula C8H12N2 and molecular weight 136.10 g/mol. UNII V80F4IA5XG; ChEBI 133246; InChIKey FINHMKGKINIASC-UHFFFAOYSA-N. Boiling Point: 190.00 °C. @ 760.00 mm Hg; Boiling Point: 190 °C; Melting Point: 86 °C.

Identification

CAS Registry Number	1124-11-4
PubChem CID	14296
Molecular formula	C8H12N2
Molecular weight	136.10 g/mol
IUPAC name	2,3,5,6-tetramethylpyrazine
InChIKey	FINHMKGKINIASC-UHFFFAOYSA-N
UNII (FDA)	V80F4IA5XG
ChEBI ID	CHEBI:133246
FEMA number	3237
JECFA number	780

Computed Descriptors

Molecular Weight	136.19
XLogP3	1.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	136.100048391
Monoisotopic Mass	136.100048391
Topological Polar Surface Area	25.8
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Boiling Point	190.00 °C. @ 760.00 mm Hg
Boiling Point	190 °C
Melting Point	86 °C
LogP	1.28

Physical description & handling notes

• Solid
• white crystals or powder with a musty, fermented, coffee odour
• slightly soluble in water; soluble in oils, propylene glycol, organic solvents
• very soluble (in ethanol)
• <0.1 [ug/mL] (The mean of the results at pH 7.4)

Regulatory Status

Regulatory & Food Contact	EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent Cocoa, Coffee, Green, Mocha, Roast No safety concern at current levels of intake when used as a flavouring agent

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
• Flavoring Agents -> JECFA Flavorings Index
• Pyrazine, 2,3,5,6-tetramethyl-: ACTIVE
• Drugs used to cause dilation of the blood vessels.

Synonyms

2,3,5,6-Tetramethylpyrazine; TETRAMETHYLPYRAZINE; 1124-11-4; Ligustrazine; Chuanxiongzine; Tetrapyrazine; chuanxingzine; FEMA No. 3237; CHUANXIONGQIN; TMPZ; 2,3,5,6,-Tetramethyl-1,4-pyrazine; DTXSID6047070; V80F4IA5XG; DTXCID4027070; NSC-36080; NSC-46451

Frequently Asked Questions

What are the CAS number and molecular formula of 2,3,5,6-Tetramethylpyrazine?

CAS 1124-11-4; molecular formula C8H12N2; molecular weight 136.10 g/mol.

What other names is 2,3,5,6-Tetramethylpyrazine known by?

2,3,5,6-Tetramethylpyrazine, TETRAMETHYLPYRAZINE, 1124-11-4, Ligustrazine, Chuanxiongzine, Tetrapyrazine.

What is the regulatory status of 2,3,5,6-Tetramethylpyrazine?

Documented regulatory listings: EU Flavoring substances; FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; Flavoring Agents.

Is 2,3,5,6-Tetramethylpyrazine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of 2,3,5,6-Tetramethylpyrazine?

Boiling Point: 190.00 °C. @ 760.00 mm Hg; Boiling Point: 190 °C; Melting Point: 86 °C; LogP: 1.28.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.