托吡酯（CAS 97240-79-4）：分子式 C12H21NO8S、分子量 339.36。
| CAS号 | 97240-79-4 |
|---|---|
| 分子式 | C12H21NO8S |
| 分子量 | 339.36 |
| 熔点 | 123-125 ºC |
| 沸点 | 438.7 |
| LogP | 0.13 |
| 应用领域 | Uses: MEDICATION、THERAP CAT: Anticonvulsant、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 10000、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.035、Excretion rate: 0.8、Calculated removal (%): 8.8、Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. Used to treat epilepsy in children and adults. It is sometimes used as an antidepressant. In children it is indicated for the treatment of Lennox-Gastaut syndrome、a disorder that causes seizures and developmental delay. It is also Food and Drug Administration (FDA) approved for、and most frequently prescribed for、the prevention of migraines. Psychiatrists have used topiramate to treat bipolar disorder、[6] but it is not FDA approved for this purpose. This drug has been investigated for use in treating alcoholism and obesity、especially to reduce binge eating.、Methods of Manufacturing: D-Fructose is reacted with acetone to produce the bisacetonide. This compound is then condensed with sulfamoyl chloride in presence of sodium hydride.、Prepn: B.E. Maryanoff、J.F. Gardocki、US 4513006 (1985 to McNeil)、Formulations、Preparations: Epitomax、Topamax |
登记用途：Uses: MEDICATION、THERAP CAT: Anticonvulsant、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 10000、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.035、Excretion rate: 0.8、Calculated removal (%): 8.8、Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. Used to treat epilepsy in children and adults. It is sometimes used as an antidepressant. In children it is indicated for the treatment of Lennox-Gastaut syndrome、a disorder that causes seizures and developmental delay. It is also Food and Drug Administration (FDA) approved for、and most frequently prescribed for、the prevention of migraines. Psychiatrists have used topiramate to treat bipolar disorder、[6] but it is not FDA approved for this purpose. This drug has been investigated for use in treating alcoholism and obesity、especially to reduce binge eating.、Methods of Manufacturing: D-Fructose is reacted with acetone to produce the bisacetonide. This compound is then condensed with sulfamoyl chloride in presence of sodium hydride.、Prepn: B.E. Maryanoff、J.F. Gardocki、US 4513006 (1985 to McNeil)、Formulations、Preparations: Epitomax、Topamax。
托吡酯 是一种化工化合物，登记 CAS 号为 97240-79-4，分子式 C12H21NO8S（分子量 339.36）。
登记 CAS 号：97240-79-4
其分子式 C12H21NO8S 由 12 个碳、21 个氢、1 个氮、8 个氧、1 个硫 组成。
别名/同义词：托吡酯 · topiramate
托吡酯 的 CAS 登记号为 97240-79-4。
分子式 C12H21NO8S，分子量 339.36。
别名/同义词：托吡酯、topiramate。
登记用途：Uses: MEDICATION、THERAP CAT: Anticonvulsant、Use (kg) in Switzerland (2009): >250、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 10000、Consumption (g per capita) in Switzerland (2009): 0.032、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.035、Excretion rate: 0.8、Calculated removal (%): 8.8、Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. Used to treat epilepsy in children and adults. It is sometimes used as an antidepressant. In children it is indicated for the treatment of Lennox-Gastaut syndrome、a disorder that causes seizures and developmental delay. It is also Food and Drug Administration (FDA) approved for、and most frequently prescribed for、the prevention of migraines. Psychiatrists have used topiramate to treat bipolar disorder、[6] but it is not FDA approved for this purpose. This drug has been investigated for use in treating alcoholism and obesity、especially to reduce binge eating.、Methods of Manufacturing: D-Fructose is reacted with acetone to produce the bisacetonide. This compound is then condensed with sulfamoyl chloride in presence of sodium hydride.、Prepn: B.E. Maryanoff、J.F. Gardocki、US 4513006 (1985 to McNeil)、Formulations、Preparations: Epitomax、Topamax。
托吡酯（CAS 97240-79-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 97240-79-4 |
|---|---|
| PubChem CID | 5284627 |
| Molecular formula | C12H21NO8S |
| IUPAC name | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate |
| UNII (FDA) | 0H73WJJ391 |
| Molecular Weight | 339.36 |
|---|---|
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 3 |
| Exact Mass | 339.09878780 |
| Monoisotopic Mass | 339.09878780 |
| Topological Polar Surface Area | 124 |
| Heavy Atom Count | 22 |
| Boiling Point | 438.7 |
|---|---|
| Melting Point | 123-125 ºC |
| Melting Point | 125-126 °C |
| Melting Point | 125 - 126 °C |
| Solubility | 9.8 |
| LogP | 0.13 |
| LogP | 0.53 |
| Dissociation Constants | 8.7 |
topiramate; 97240-79-4; Topamax; Epitomax; Topamax Sprinkle; Topina; Tipiramate; Topiramato; Topiramatum; Epitoma; Topimax; Topomax; McN-4853; Tipiramato; Topamac; RWJ-17021
| Reported hazard statements | H315 (85.1%), H319 (86%), H335 (85.1%), H361 (14.9%), H351, H360, H371, H372 |
|---|
H315 (85.1%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (86%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
topiramate · CAS 97240-79-4 · C12H21NO8S. UNII 0H73WJJ391. Boiling Point: 438.7; Melting Point: 123-125 ºC; Melting Point: 125-126 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: topiramate