Sodium 4-Phenylbutyrate

Independent reference data for Sodium 4-Phenylbutyrate (CAS 1716-12-7), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Documented uses on record

Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies. The urea cycle is the major pathway of elimination of excess nitrogen including ammonia, and absence of one of the urea cycle enzymes often causes elevations in serum ammonia which can be severe, life-threatening and result in permanent neurologic damage and cognitive deficiencies. Both phenylbutyrate and sodium benzoate actBreast Feeding; Lactation; Milk, Human; Urea Cycle Disorders

Synonyms and trade names

Sodium 4-phenylbutyrate; SODIUM PHENYLBUTYRATE; 1716-12-7; Buphenyl; TriButyrate; Benzenebutanoic acid, sodium salt; Ammonaps; Pheburane; 4-phenylbutyric acid, sodium salt; OLPRUVA; DTXSID7040948; NT6K61736T; ACER-001; NSC-657802; DTXCID5020948; CHEBI:75316

Regulatory listings held on file

GHS notification summary	2.3% (1 / 44)

GHS hazard classification

GHS notification summary	2.3% (1 / 44)
Reported hazard statements	H319 (93.2%)

This chemical does not meet GHS hazard criteria for 2.3% (1 of 44) of reports.

H319 (93.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

What the public record says

Sodium 4-Phenylbutyrate · CAS 1716-12-7 · C10H11NaO2. UNII NT6K61736T.

Source: PubChem / Wikidata; the batch COA governs where values differ.