醋酸罗沙替丁

Description

Roxatidine acetate · CAS 78628-28-1 · C19H28N2O4. UNII ZUP3LSD0DO.

Identification

CAS Registry Number	78628-28-1
PubChem CID	5105
Molecular formula	C19H28N2O4
IUPAC name	[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate
UNII (FDA)	ZUP3LSD0DO

Computed Descriptors

Molecular Weight	348.4
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	348.20490738
Monoisotopic Mass	348.20490738
Topological Polar Surface Area	67.9
Heavy Atom Count	25
Formal Charge	0

Physical description & handling notes

• Solid
• 145-146 for HCl salt
• 145 - 146 (hydrochloride salt)
• Roxatidine acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist). This suppressive action is dose-dependent. As a result, the production and secretion, particularly of gastric acid, are reduced. Roxatidine acetate has no antiandrogenic effects and does not influence drug-metabolizing enzymes in the liver.

Documented Uses

• For the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also for prophylaxis of recurrent gastric and duodenal ulcers
• Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
• Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
• Well absorbed orally (80–90% bioavailability).
• Roxatidine acetate is rapidly metabolised to the primary, active desacetyl metabolite.
• Roxatidine acetate Action Pathway

Synonyms

ROXATIDINE ACETATE; 78628-28-1; Pifatidine; ZUP3LSD0DO; DTXSID2048325; ((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)carbamoyl)methyl acetate; ({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}carbamoyl)methyl acetate; RefChem:930911; DTXCID7028300; Aceroxatidine; Roxane; [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate; 2-Oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethyl acetate; Aceroxatidine; Pifatidine; Acetamide, 2-(acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-; Roxatidinum [Latin]

Frequently Asked Questions

What are the CAS number and molecular formula of Roxatidine acetate?

CAS 78628-28-1; molecular formula C19H28N2O4; molecular weight — g/mol.

What other names is Roxatidine acetate known by?

ROXATIDINE ACETATE, 78628-28-1, Pifatidine, ZUP3LSD0DO, DTXSID2048325, ((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)carbamoyl)methyl acetate.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.