盐酸氮芥

Description

mechlorethamine hydrochloride · CAS 55-86-7 · C5H11Cl2N.ClH. UNII L0MR697HHI. Melting Point: 226 to 232 °F (NTP, 1992); Melting Point: 109-111 °C; Melting Point: 111.5 °C.

Identification

CAS Registry Number	55-86-7
PubChem CID	5935
Molecular formula	C5H11Cl2N.ClH
IUPAC name	2-chloro-N-(2-chloroethyl)-N-methylethanamine;hydrochloride
UNII (FDA)	L0MR697HHI

Computed Descriptors

Molecular Weight	192.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	4
Exact Mass	191.003532
Monoisotopic Mass	191.003532
Topological Polar Surface Area	3.2
Heavy Atom Count	9
Formal Charge	0
Complexity	43.7

Physical & Chemical Properties

Melting Point	226 to 232 °F (NTP, 1992)
Melting Point	109-111 °C
Melting Point	111.5 °C
Density	1.118 @25 °C

Physical description & handling notes

• Nitrogen mustard hydrochloride appears as white to off-white crystals or powder with a fishy odor. Initial pH (2% aqueous solution) 3.0-4.0. (NTP, 1992)
• Hygroscopic leaflets from acetone or chloroform
• White hygroscopic crystals
• White, crystalline, hygroscopic powder
• greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
• Soluble in ethanol

GHS Hazard Classification

Reported hazard statements	H300, H310 (97.5%), H314 (97.5%), H340 (97.5%), H350 (97.5%), H360 (95%)

Documented Uses

• Its use as chemosterilant and as cross-linking agent in mfr of ion exchange fibers was investigated. /mechlorethamine hydrochloride/
• For the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion.
• Nitrogen mustard hydrochloride can be prepared by treating N-methyldiethanolamine with thionyl chloride.
• After purification, base may then be converted conveniently to hydrochloride by dissolving it in suitable organic solvent and passing hydrochloride into solution.
• ... 1.5 kg of the chemical were manufactured and sold in 1974 in the US.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Alkylating Agents; Irritants

Synonyms

55-86-7; Mechlorethamine hydrochloride; Chlormethine hydrochloride; 2-CHLORO-N-(2-CHLOROETHYL)-N-METHYLETHANAMINE HYDROCHLORIDE; Mechlorethamine HCl; Nitrogen mustard hydrochloride; Chlorethamine; Chlormethinum; Stickstofflost; Chloramin; Mustine hydrochloride; HN2 hydrochloride; Azotoyperite; Dichloren; Dimitan; Embikhine

Frequently Asked Questions

What are the CAS number and molecular formula of mechlorethamine hydrochloride?

CAS 55-86-7; molecular formula C5H11Cl2N.ClH; molecular weight — g/mol.

What other names is mechlorethamine hydrochloride known by?

55-86-7, Mechlorethamine hydrochloride, Chlormethine hydrochloride, 2-CHLORO-N-(2-CHLOROETHYL)-N-METHYLETHANAMINE HYDROCHLORIDE, Mechlorethamine HCl, Nitrogen mustard hydrochloride.

Is mechlorethamine hydrochloride classified as hazardous?

Hazard statements reported: H300, H310, H314, H340, H350.

What are the key physical properties of mechlorethamine hydrochloride?

Melting Point: 226 to 232 °F (NTP, 1992); Melting Point: 109-111 °C; Melting Point: 111.5 °C; Density: 1.118 @25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.