二甲苯磺酸拉帕替尼一水合物

Name: 二甲苯磺酸拉帕替尼一水合物
Brand: 济南圣和化工有限公司

CAS 388082-78-8C29H26ClFN4O4SMW 581.1

济南圣和化工主营供应二甲苯磺酸拉帕替尼一水合物（CAS 388082-78-8），归类于有机化学品，分子式 C29H26ClFN4O4S，分子量 581.1。我们面向国内化工贸易与生产企业提供稳定的现货供应，报价响应快，支持对公转账并可开具增值税发票。

产品概览

CAS号	388082-78-8
分子式	C29H26ClFN4O4S
分子量	581.1
LogP	5.4
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	有机化学品
类别	有机化学品

应用领域

有机化学品

二甲苯磺酸拉帕替尼一水合物在有机化学品领域使用广泛。采购前请确认纯度等级与包装形式，以批次 COA 为验收依据。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供应说明：二甲苯磺酸拉帕替尼一水合物常规包装为按订单/批次确认(不公开发布)，储存时应密封置于阴凉干燥处，避免与氧化剂混放。济南圣和化工有限公司支持国内物流发货，大货交期与运费以订单确认为准。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

选择济南圣和化工有限公司的理由：产品信息透明（含 CAS、分子式、理化参数）、报价响应快（一个工作日内）、单证齐全（COA/MSS/质检资料按需提供）、支持批量与长期协议供货。如需二甲苯磺酸拉帕替尼一水合物以外的配套原料，也欢迎一并列出需求清单。

常见问题

二甲苯磺酸拉帕替尼一水合物的 CAS 号是多少？

二甲苯磺酸拉帕替尼一水合物的 CAS 号为 388082-78-8。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

二甲苯磺酸拉帕替尼一水合物有什么用途？

主要应用于有机化学品。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

Lapatinib ditosylate monohydrate · CAS 388082-78-8 · C29H26ClFN4O4S. UNII 0VUA21238F. Solubility: 2.23e-02 g/L; LogP: 5.4.

Identification

CAS Registry Number	388082-78-8
PubChem CID	208908
Molecular formula	C29H26ClFN4O4S
IUPAC name	N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
UNII (FDA)	0VUA21238F

Computed Descriptors

Molecular Weight	581.1
XLogP3	5.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	580.1347324
Monoisotopic Mass	580.1347324
Topological Polar Surface Area	115
Heavy Atom Count	40
Formal Charge	0

Physical & Chemical Properties

Solubility	2.23e-02 g/L
LogP	5.4

Physical description & handling notes

Solid
Yellow solid. Solubility at 25 eg C (mg/mL): 0.007 in water; 0.001 in 0.1 N HCl /Lapatinib ditoluenesulfonate monohydrate/
Stable if stored as directed; avoid strong oxidizing agents.
Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
pKa1 = 3.80 (amine); pKa2 = 7.20 (amine)
Lapatinib is a small molecule and a member of the 4-anilinoquinazoline class of kinase inhibitors. An anti-cancer drug, lapatinib was developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine.

GHS Hazard Classification

Reported hazard statements	H319 (50%), H362 (100%), H413 (100%)

H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

Documented Uses

Antineoplastic Agents; Protein Kinase Inhibitors
Use (kg; approx.) in Germany (2009): >250
Use (kg; exact) in Germany (2009): 287
Consumption (g per capita; approx.) in Germany (2009): 0.00305
Consumption (g per capita; exact) in Germany (2009): 0.0035
The synthesis route for /lapatinib/ ... involves a Suzuki coupling of 5-formyl-2-furanboronic acid with the iodo-substituted quinazoline derivative.

Synonyms

Lapatinib; 231277-92-2; GW572016; GW 572016; GSK 572016; DTXSID7046675; GW-572016; GSK572016; GSK-572016; 0VUA21238F; GW-572016X; DTXCID5026675; CHEBI:49603; GW2016; lapatinibum; RefChem:798502

Frequently Asked Questions

What are the CAS number and molecular formula of Lapatinib ditosylate monohydrate?

CAS 388082-78-8; molecular formula C29H26ClFN4O4S; molecular weight — g/mol.

What other names is Lapatinib ditosylate monohydrate known by?

Lapatinib, 231277-92-2, GW572016, GW 572016, GSK 572016, DTXSID7046675.

Is Lapatinib ditosylate monohydrate classified as hazardous?

Hazard statements reported: H319, H362, H413.

What are the key physical properties of Lapatinib ditosylate monohydrate?

Solubility: 2.23e-02 g/L; LogP: 5.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.