吉美拉西尔

Description

GIMERACIL · CAS 103766-25-2 · C5H4ClNO2. UNII UA8SE1325T.

Identification

CAS Registry Number	103766-25-2
PubChem CID	54679224
Molecular formula	C5H4ClNO2
IUPAC name	5-chloro-4-hydroxy-1H-pyridin-2-one
UNII (FDA)	UA8SE1325T

Computed Descriptors

Molecular Weight	145.54
XLogP3	-0.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	144.9930561
Monoisotopic Mass	144.9930561
Topological Polar Surface Area	49.3
Heavy Atom Count	9
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (50%), H319 (50%), H335 (50%)

Documented Uses

• Gimeracil is used as an adjunct to antineoplastic therapy. When used within the product Teysuno, gimeracil is indicated for the treatment of adults with advanced gastric (stomach) cancer when given in combination with cisplatin.
• Drink plenty of fluids. Drinking water is important to prevent dehydration when taking Teysuno.
• Take on an empty stomach. Take Teysuno at least 1 hour before or after eating.
• Following a single dose of Teysuno, approximately 3.8% to 4.2% of administered tegafur, 65% to 72% of administered gimeracil, and 3.5% to 3.9% of administered oteracil were excreted unchanged in the urine.
• Although no intravenous data are available for Teysuno in humans, the volume of distribution could be roughly estimated from the apparent volume of distribution and urinary excretion data as 16 l/m2, 17 l/m2, and 23 l/m2 for tegafur, gimeracil and oteracil, respectively.
• Oteracil, gimeracil, 5-FU, and tegafur are 8.4%, 32.2%, 18.4%, and 52.3% protein bound, respectively.

Synonyms

Gimeracil; 103766-25-2; 5-Chloro-2,4-dihydroxypyridine; gimestat; 5-Chloro-2,4-pyridinediol; DTXSID8046799; Gimeracilo; UA8SE1325T; DTXCID6026799; TEYSUNO COMPONENT GIMERACIL; CDHP; gimeracilum; Chlorodihydroxypyridine; RefChem:639937; 5-chloropyridine-2,4-diol; 5-Chloro-4-hydroxy-1H-pyridin-2-one

Frequently Asked Questions

What are the CAS number and molecular formula of GIMERACIL?

CAS 103766-25-2; molecular formula C5H4ClNO2; molecular weight — g/mol.

What other names is GIMERACIL known by?

Gimeracil, 103766-25-2, 5-Chloro-2,4-dihydroxypyridine, gimestat, 5-Chloro-2,4-pyridinediol, DTXSID8046799.

Is GIMERACIL classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.