Fotemustine

Description

Fotemustine · CAS 92118-27-9 · C9H19ClN3O5P. UNII GQ7JL9P5I2. Melting Point: 85 °C.

Identification

CAS Registry Number	92118-27-9
PubChem CID	104799
Molecular formula	C9H19ClN3O5P
IUPAC name	1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
UNII (FDA)	GQ7JL9P5I2

Computed Descriptors

Molecular Weight	315.69
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	315.0750854
Monoisotopic Mass	315.0750854
Topological Polar Surface Area	97.3
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	85 °C

Physical description & handling notes

• Solid
• 208 mg powder for injection, Muphoran (Servier Lab (Aust) Pty Ltd, Server Lab (NZ) Ltd.

GHS Hazard Classification

Reported hazard statements	H351 (97.4%)

Documented Uses

• Amino acid-linked nitrosourea alkylating agent.[The Merck Index, Fourteenth Edition (2006)
• Drug Category: Antineoplastic agent
• Antineoplastic[The Merck Index, Fourteenth Edition (2006)
• The indication "disseminated malignant melanoma", including cerebral metastases, is currently the preferential indication for fotemustine, administered alone or in combination with other anticancer agents.
• For more Therapeutic Uses (Complete) data for Fotemustine (6 total), please visit the HSDB record page.
• Because of the known mutagenic and carcinogenic potential of nitrosoureas, administration to pregnant women is contraindicated. Contraindicated in lactation.

Synonyms

Fotemustine; 92118-27-9; Muphoran; Mustophorane; Fotemustina; Mustoforan; Servier-10036; Fotemustinum; S-10036; S 10036; GQ7JL9P5I2; Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate; s10036; DTXSID80869091; Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester; RefChem:600364

Frequently Asked Questions

What are the CAS number and molecular formula of Fotemustine?

CAS 92118-27-9; molecular formula C9H19ClN3O5P; molecular weight — g/mol.

What other names is Fotemustine known by?

Fotemustine, 92118-27-9, Muphoran, Mustophorane, Fotemustina, Mustoforan.

Is Fotemustine classified as hazardous?

Hazard statements reported: H351.

What are the key physical properties of Fotemustine?

Melting Point: 85 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.