Fluprednisolone

Description

Fluprednisolone · CAS 53-34-9 · C21H27FO5. UNII 9H05937G3X. Melting Point: 208-213 °C.

Identification

CAS Registry Number	53-34-9
PubChem CID	5876
Molecular formula	C21H27FO5
IUPAC name	(6S,8S,9S,10R,11S,13S,14S,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
UNII (FDA)	9H05937G3X

Computed Descriptors

Molecular Weight	378.4
XLogP3	1.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	378.18425212
Monoisotopic Mass	378.18425212
Topological Polar Surface Area	94.8
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	208-213 °C

Physical description & handling notes

• WHITE TO OFF-WHITE POWDER
• Crystals
• ODORLESS
• Crystals. MP: 235-238 °C /21-Acetate/
• SPARINGLY SOL IN ALC, METHANOL, ETHYL ACETATE. SLIGHTLY SOL IN CHLOROFORM, ETHER, ETHYLENE DICHLORIDE. VERY SLIGHTLY SOL IN BENZENE.
• Specific optical rotation: +92 deg

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (100%), H361 (100%), H362 (100%), H373 (100%)

Documented Uses

• THERAP CAT: Glucocortioid; anti-inflammatory
• THERAP CAT (VET): Anti-inflammatory
• Preparation: Hogg, Spero, US 2841600 (1958 to Upjohn); Batres et al, DE 1079042 (1960 to Syntex); Lettre, Hotz, DE 1088953 (1960 to Bayer).
• Synthesized with methods developed by Upjohn, Syntex, and Bayer.
• Anti-Inflammatory Agents, Steroidal; Glucocorticoids, Synthetic
• .../FLUPREDNISOLONE/ IS APPROX 2.5 TIMES AS POTENT AS PREDNISOLONE & 40 TIMES AS POTENT AS CORTISONE. HOWEVER, OCCASIONALLY IT DOES NOT APPEAR...ABLE TO CONTROL ALLERGIC OR INFLAMMATORY CONDITIONS THAT CAN BE CONTROLLED WITH OTHER GLUCOCORTICOIDS. FLUPREDNISOLONE ALSO HAS ERRATIC MINERALOCORTICOID ACTIVITY.

Synonyms

fluprednisolone; 53-34-9; Alphadrol; Etadrol; Vladicort; 6alpha-Fluoroprednisolone; Fluprednisolonum; DTXSID5046067; fluprednisolona; NSC-47439; U-7800; 6alpha-Fluoro-1-dehydrohydrocortisone; FI 6150; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-, (6alpha,11beta)-; 9H05937G3X; DTXCID3026067

Frequently Asked Questions

What are the CAS number and molecular formula of Fluprednisolone?

CAS 53-34-9; molecular formula C21H27FO5; molecular weight — g/mol.

What other names is Fluprednisolone known by?

fluprednisolone, 53-34-9, Alphadrol, Etadrol, Vladicort, 6alpha-Fluoroprednisolone.

Is Fluprednisolone classified as hazardous?

Hazard statements reported: H302, H312, H361, H362, H373.

What are the key physical properties of Fluprednisolone?

Melting Point: 208-213 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.