硫酸新霉素

Description

framycetin sulphate · CAS 4146-30-9 · C23H46N6O13. UNII 4BOC774388. Melting Point: 6 °C (sulfate form); Solubility: 6.47e+01 g/L; LogP: -7.8.

Identification

CAS Registry Number	4146-30-9
PubChem CID	8378
Molecular formula	C23H46N6O13
IUPAC name	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
UNII (FDA)	4BOC774388

Computed Descriptors

Molecular Weight	614.6
XLogP3	-9
Hydrogen Bond Donor Count	13
Hydrogen Bond Acceptor Count	19
Rotatable Bond Count	9
Exact Mass	614.31228554
Monoisotopic Mass	614.31228554
Topological Polar Surface Area	353
Heavy Atom Count	42
Formal Charge	0

Physical & Chemical Properties

Melting Point	6 °C (sulfate form)
Solubility	6.47e+01 g/L
LogP	-7.8
LogP	log Kow = -3.70
Dissociation Constants	pKa = 12.9; pKb = 9.52 (25 °C)

Physical description & handling notes

• Liquid
• Soluble in water ... solutions up to 250 mg/mL may be prepared
• Soluble in methanol, acidified alcohols; practically insoluble in common organic solvents
• Henry's Law constant range: 8.5X10-12 to 4.1X10-8 Pa-cu m/mol (Aminoglycosides) (etc)
• Hygroscopic. /Neomycin sulfate/
• Crystals from methanol, MP 334-336 °C. Specific optical rotation at 25 °C for D (sodium) line = +87 deg (c = 1) /Neomycin A N-acetyl derivative/

Regulatory Status

Regulatory & Food Contact	ANTIMICROBIAL_AGENT: Veterinary Drug 0–60 μg/kg bw TRS 918-JECFA 60/5 FAS 51-JECFA 60/3

GHS Hazard Classification

Reported hazard statements	H302 (100%), H317 (100%), H334 (100%), H332 (15.4%), H361 (84.6%), H373 (76.9%)

Documented Uses

• ... Used for bladder irrigation ... to prevent bacteriuria and bacteremia associated with the use of indwelling catheters.
• For more Uses (Complete) data for Neomycin (7 total), please visit the HSDB record page.
• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
• Produced by Streptomyces fradiae.

Synonyms

neomycin; Fradiomycin; Neomas; Nivemycin; Myacyne; Neolate; Caswell No. 595; Vonamycin powder V; Neomin; Neomicina; Neomycine; Neomycinum; 1404-04-2; PIMAVECORT; I16QD7X297; VONAMYCIN

Frequently Asked Questions

What are the CAS number and molecular formula of framycetin sulphate?

CAS 4146-30-9; molecular formula C23H46N6O13; molecular weight — g/mol.

What other names is framycetin sulphate known by?

neomycin, Fradiomycin, Neomas, Nivemycin, Myacyne, Neolate.

What is the regulatory status of framycetin sulphate?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; 0–60 μg/kg bw; TRS 918-JECFA 60/5.

Is framycetin sulphate classified as hazardous?

Hazard statements reported: H302, H317, H334, H332, H361.

What are the key physical properties of framycetin sulphate?

Melting Point: 6 °C (sulfate form); Solubility: 6.47e+01 g/L; LogP: -7.8; LogP: log Kow = -3.70.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.