Fluphenazine HCL

Description

Fluphenazine HCL · CAS 146-56-5 · C22H26F3N3OS. UNII S79426A41Z. Boiling Point: 268-274 °C at 5.00E-01 mm Hg; Boiling Point: BP: 250-252 °C at 0.3 mm Hg; 268-274 °C at 0.5 mm Hg; Melting Point: 224-226 (Salt).

Identification

CAS Registry Number	146-56-5
PubChem CID	3372
Molecular formula	C22H26F3N3OS
IUPAC name	2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
UNII (FDA)	S79426A41Z

Computed Descriptors

Molecular Weight	437.5
XLogP3	4.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	437.17486812
Monoisotopic Mass	437.17486812
Topological Polar Surface Area	55.3
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Boiling Point	268-274 °C at 5.00E-01 mm Hg
Boiling Point	BP: 250-252 °C at 0.3 mm Hg; 268-274 °C at 0.5 mm Hg
Melting Point	224-226 (Salt)
Melting Point	< 25 °C
Solubility	31.1
Solubility	In water, 31.1 g/L (31.3 mg/L) at 37 °C
Solubility	1.90e-02 g/L
LogP	4.36
LogP	log Kow = 4.36
LogP	4.2

Physical description & handling notes

• Solid
• Dark brown viscous oil
• Crystals from absolute alcohol. MP: 235-237 °C, also reported as 224.5-226 °C /Fluphenazine dihydrochloride/
• Pale yellow-orange, viscous liquid. Slowly crystallizes at room temperature. MP: 30-32 °C. Very soluble in chloroform, ether, cyclohexane, methanol, ethanol. Insoluble in water /Fluphenazine decanoate/
• Light sensitive. /Fluphenazine Decanoate/
• Unstable in strong light, but stable in air at room temperature. /Fluphenazine Enanthate/

GHS Hazard Classification

Reported hazard statements	H301 (100%), H315 (100%), H318 (100%), H330 (100%), H370 (20.8%)

Documented Uses

• A phenothiazine used in the treatment of psychoses
• THERAPEUTIC CATEGORY: Antipsychotic
• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• For management of manifestations of psychotic disorders.
• Fluphenazine may be prepared by condensing 2-(trifluoromethyl)-10-(3-chloropropyl)phenothiazine with 1-piperazineethanol in toluene with the aid of sodamide. ... The starting phenothiazine compound may be prepared by heating 3-(trifluoromethyl)diphenylamine with sulfur and condensing the resulting 2-(trifluoromethyl)phenothiazine with 1-bromo-3-chloropropane.

Synonyms

FLUPHENAZINE; 69-23-8; Triflumethazine; Fluorfenazine; Fluorophenazine; Fluorphenazine; Siqualine; Sevinol; Flufenazina; Fluphenazinum; SQ 4918; Flufenazin; 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol; Moditen; 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine; DTXSID2023068

Frequently Asked Questions

What are the CAS number and molecular formula of Fluphenazine HCL?

CAS 146-56-5; molecular formula C22H26F3N3OS; molecular weight — g/mol.

What other names is Fluphenazine HCL known by?

FLUPHENAZINE, 69-23-8, Triflumethazine, Fluorfenazine, Fluorophenazine, Fluorphenazine.

Is Fluphenazine HCL classified as hazardous?

Hazard statements reported: H301, H315, H318, H330, H370.

What are the key physical properties of Fluphenazine HCL?

Boiling Point: 268-274 °C at 5.00E-01 mm Hg; Boiling Point: BP: 250-252 °C at 0.3 mm Hg; 268-274 °C at 0.5 mm Hg; Melting Point: 224-226 (Salt); Melting Point: < 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.