培美曲塞二钠

Description

Pemetrexed Disodium · CAS 150399-23-8 · C20H19N5Na2O6. UNII 2PKU919BA9.

Identification

CAS Registry Number	150399-23-8
PubChem CID	135413520
Molecular formula	C20H19N5Na2O6
IUPAC name	disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
UNII (FDA)	2PKU919BA9

Computed Descriptors

Molecular Weight	471.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	471.11307191
Monoisotopic Mass	471.11307191
Topological Polar Surface Area	193
Heavy Atom Count	33
Formal Charge	0
Complexity	737

GHS Hazard Classification

Reported hazard statements	H315 (26.7%), H319 (80%), H335 (66.7%), H341 (93.3%), H360 (93.3%), H373 (13.3%)

Documented Uses

• Pemetrexed disodium is approved to be used alone or with other drugs to treat:
• • Malignant pleural mesothelioma. It is used with cisplatin as the first treatment in patients whose cancer cannot be removed by surgery or who are not able to have surgery.
• • Nonsquamous non-small cell lung cancer. It is used:
• • With pembrolizumab and platinum chemotherapy as the first treatment in patients whose cancer has spread to other parts of the body and does not have an abnormal EGFR or ALK gene.
• • With cisplatin as the first treatment in patients whose cancer has spread.
• • Alone as maintenance therapy in patients whose cancer has spread and did not get worse after four cycles of platinum-based chemotherapy as the first treatment.

Synonyms

Pemetrexed disodium; 150399-23-8; Pemetrexed sodium salt; DTXSID8046660; LY231514 DISODIUM SALT; LY-231514 DISODIUM SALT; 2PKU919BA9; CHEBI:63722; DTXCID6026660; NSC698037; Almita; Disodium, Pemetrexed; RefChem:55816; 604-733-2; Alimta; Rolazar

Frequently Asked Questions

What are the CAS number and molecular formula of Pemetrexed Disodium?

CAS 150399-23-8; molecular formula C20H19N5Na2O6; molecular weight — g/mol.

What other names is Pemetrexed Disodium known by?

Pemetrexed disodium, 150399-23-8, Pemetrexed sodium salt, DTXSID8046660, LY231514 DISODIUM SALT, LY-231514 DISODIUM SALT.

Is Pemetrexed Disodium classified as hazardous?

Hazard statements reported: H315, H319, H335, H341, H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.