AMITRIPTYLINE HCl

Description

AMITRIPTYLINE HCl · CAS 549-18-8 · C20H24ClN. UNII 26LUD4JO9K.

Identification

Computed Descriptors

Physical description & handling notes

• >47.1 [ug/mL] (The mean of the results at pH 7.4)
• 166.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS Hazard Classification

Documented Uses

• For the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.
• 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1): INACTIVE
• Amitriptyline Hydrochloride; Chlordiazepoxide
• Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
• A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
• Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Synonyms

Amitriptyline hydrochloride; 549-18-8; Amitriptyline HCl; Syneudon; Etravil; Novoprotect; Amitid; Amitril; Saroten Retard; NIH 10794; DTXSID9033187; 26LUD4JO9K; NSC-104210; Amitriptylini hydrochloridum; 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride; DTXCID7013187

Frequently Asked Questions

What are the CAS number and molecular formula of AMITRIPTYLINE HCl?

CAS 549-18-8; molecular formula C20H24ClN; molecular weight — g/mol.

What other names is AMITRIPTYLINE HCl known by?

Amitriptyline hydrochloride, 549-18-8, Amitriptyline HCl, Syneudon, Etravil, Novoprotect.

Is AMITRIPTYLINE HCl classified as hazardous?

0.7% of GHS notifications report no hazard classification (1 of 136).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.